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Displaying results 1 - 10 of 483 in total
  1. Target

    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

    go.drugbank.com/bio_entities/BE0000423
    TargetTransporterHumans

    Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract.

    Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)Synonyms: Amino acid transporter ATB0+
  2. Target

    Fructose-bisphosphate aldolase A

    go.drugbank.com/bio_entities/BE0001683
    TargetEnzymeHumans

    Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). … In response to glucose deprivation, FBP dissociates from aldolase and acts as an adapter that promotes AMP-activated protein kinase (AMPK) activity: mechanistically, associates with transient receptor

    Polypeptides: Fructose-bisphosphate aldolase A
  3. Target

    Glycogen phosphorylase, liver form

    go.drugbank.com/bio_entities/BE0000007
    TargetHumans

    and organismal glucose homeostasis … Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular

    Polypeptides: Glycogen phosphorylase, liver form
  4. Target

    Glucose--fructose oxidoreductase

    go.drugbank.com/bio_entities/BE0001552
    TargetZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

    Polypeptides: Glucose--fructose oxidoreductaseFunction: glucose-fructose oxidoreductase activity
  5. Target

    Fructose-bisphosphate aldolase

    go.drugbank.com/bio_entities/BE0009172
    TargetPlasmodium falciparum

    Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:2190085). … ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete

    Polypeptides: Fructose-bisphosphate aldolase
  6. Target

    Glycogen phosphorylase, muscle form

    go.drugbank.com/bio_entities/BE0000916
    TargetHumans

    and organismal glucose homeostasis … Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular

    Polypeptides: Glycogen phosphorylase, muscle form
  7. Target

    Glycogen phosphorylase, brain form

    go.drugbank.com/bio_entities/BE0002150
    TargetHumans

    However, all known phosphorylases share catalytic and structural properties (PubMed:3346228) … Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228).

    Polypeptides: Glycogen phosphorylase, brain form
  8. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  9. Target

    Fructose-1,6-bisphosphatase 1

    go.drugbank.com/bio_entities/BE0002431
    TargetHumans

    Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. … Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and

    Polypeptides: Fructose-1,6-bisphosphatase 1Synonyms: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
  10. Target

    Fructose-bisphosphate aldolase B

    go.drugbank.com/bio_entities/BE0004565
    TargetHumans

    Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol … In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126

    Polypeptides: Fructose-bisphosphate aldolase B