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Displaying results 1 - 10 of 225 in total
  1. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  2. Target

    O-methyltransferase

    go.drugbank.com/bio_entities/BE0003784
    TargetEnzymeSynechocystis sp. (strain PCC 6803 / Kazusa)

    Polypeptides: O-methyltransferase
  3. Target

    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

    go.drugbank.com/bio_entities/BE0000423
    TargetTransporterHumans

    Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766)

    Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
  4. Target

    B- and T-lymphocyte attenuator

    go.drugbank.com/bio_entities/BE0010629
    TargetHumans

    Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

    Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated protein
  5. Target

    Carnitine O-acetyltransferase

    go.drugbank.com/bio_entities/BE0000496
    TargetEnzymeHumans

    Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643) … Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio.

    Polypeptides: Carnitine O-acetyltransferase
  6. Target

    Choline O-acetyltransferase

    go.drugbank.com/bio_entities/BE0000519
    EnzymeTargetHumans

    Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses

    Polypeptides: Choline O-acetyltransferaseFunction: choline O-acetyltransferase activity
  7. Target

    Galactoside O-acetyltransferase

    go.drugbank.com/bio_entities/BE0001404
    TargetEscherichia coli (strain K12)

    Catalyzes the CoA-dependent transfer of an acetyl group to the 6-O-methyl position of a range of galactosides, glucosides, and lactosides (PubMed:14009486, PubMed:4630409, PubMed:7592843).

    Polypeptides: Galactoside O-acetyltransferaseSynonyms: Acetyl-CoA:galactoside 6-O-acetyltransferase
  8. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. … DNA- and RNA binding protein, involved in several nuclear processes.

    Polypeptides: Splicing factor, proline- and glutamine-rich
  9. Target

    Cocaine- and amphetamine-regulated transcript protein

    go.drugbank.com/bio_entities/BE0000867
    TargetHumans

    Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced … It promotes neuronal development and survival in vitro

    Polypeptides: Cocaine- and amphetamine-regulated transcript protein
  10. Target

    Multidrug and toxin extrusion protein 1

    go.drugbank.com/bio_entities/BE0003657
    TransporterTargetHumans

    Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed … Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230,

    Polypeptides: Multidrug and toxin extrusion protein 1