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Displaying results 1 - 10 of 258 in total
  1. Target

    Plasmepsin I

    go.drugbank.com/bio_entities/BE0009204
    TargetPlasmodium falciparum (isolate 3D7)

    During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an essential step which...

    Polypeptides: Plasmepsin ISynonyms: Aspartic hemoglobinase I
  2. Target

    Signal peptidase I

    go.drugbank.com/bio_entities/BE0001322
    TargetEscherichia coli (strain K12)

    Polypeptides: Signal peptidase ISynonyms: SPase I, Leader peptidase I
  3. Target

    Colicin I receptor

    go.drugbank.com/bio_entities/BE0004172
    TargetTransporterEscherichia coli (strain K12)

    Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB.

    Polypeptides: Colicin I receptor
  4. Target

    DNA polymerase I

    go.drugbank.com/bio_entities/BE0000498
    TargetEscherichia coli (strain K12)

    It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template.

    Polypeptides: DNA polymerase ISynonyms: POL I
  5. Target

    Apolipoprotein A-I

    go.drugbank.com/bio_entities/BE0003449
    CarrierTargetEnzymeHumans

    Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPA...

    Polypeptides: Apolipoprotein A-ISynonyms: ApoA-I
  6. Target

    DNA polymerase I

    go.drugbank.com/bio_entities/BE0003871
    TargetGeobacillus stearothermophilus

    In addition to polymerase activity, the recombinant enzyme has strand displacement and 5'-3' exonuclease activity, but lacks proofreading 3'-5' exonuclease activity.

    Polypeptides: DNA polymerase ISynonyms: POL I
  7. Target

    Complement factor I

    go.drugbank.com/bio_entities/BE0009054
    TargetHumans

    Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the al...

    Polypeptides: Complement factor I
  8. Target

    DNA polymerase I, thermostable

    go.drugbank.com/bio_entities/BE0001665
    TargetThermus aquaticus

    In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Unlikely to have 3'-5' exonuclease activity due to absence of a 3'-5' exonuclease domain (Probable).

    Polypeptides: DNA polymerase I, thermostable
  9. Target

    Type I iodothyronine deiodinase

    go.drugbank.com/bio_entities/BE0009854
    EnzymeTargetHumans

    Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:32718224, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) ...

    Polypeptides: Type I iodothyronine deiodinaseSynonyms: Type-I 5'-deiodinase
  10. Target

    Keratin, type I cytoskeletal 16

    go.drugbank.com/bio_entities/BE0009086
    TargetHumans

    Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin intermediate filament networks that contribute to cytoskeletal resilience of ...

    Polypeptides: Keratin, type I cytoskeletal 16