Search

Displaying all 4 results
  1. Pathway

    Naltrexone Metabolism

    smpdb.ca/view/SMP0125328
    Metabolic

    In the liver naltrexone is metabolized into 6-beta-naltrexol. It was predicted by biotransformer that Cytochrome P450 2C9 metabolizes naltrexone into 6-beta-naltrexol. … Only 2% of naltrexone remains as the original naltrexone while the remainder is metabolized into 6-beta-naltrexol and other minor metabolites.

    Drugs: Naltrexone · Mesoheme
  2. Pathway

    Naltrexone Action Pathway

    smpdb.ca/view/SMP0000687
    Drug action

    Naltrexone is also a type of medication that are used for manage opioid or alcohol dependence. … Naltrexone (also known as ReVia and Vivitrol) is a competitive antagonist of mu-type opioid receptor in the central nervous system (CNS).

    Drugs: ATP · Norepinephrine · Naltrexone · Dopamine · Potassium cation · Calcium
  3. Pathway

    Naltrexone Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0125274
    Drug action

    The major metabolite, 6-β-naltrexol is also a opioid antagonist that may contribute to the effects of naltrexone. … Naltrexone inhibits Mu, Kappa, and Delta opioid receptors, with the highest affinity for the mu-type opioid receptors.

    Drugs: ATP · Naltrexone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 more
  4. Pathway

    Apparent Mineralocorticoid Excess Syndrome

    smpdb.ca/view/SMP0000717
    Disease

    Apparent mineralocorticoid excess (AME), also known as cortisol 11-beta-ketoreductase deficiency, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the steroidogenesis

    Drugs: NADH · Progesterone · Hydrocortisone · Mesoheme · Cholesterol · Corticosterone +1 more