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Displaying results 1 - 10 of 15 in total
  1. Target

    Tyrosine-protein kinase FRK

    go.drugbank.com/bio_entities/BE0004742
    TargetHumans

    Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possi...

    Polypeptides: Tyrosine-protein kinase FRK
  2. Target

    Frataxin, mitochondrial

    go.drugbank.com/bio_entities/BE0008991
    TargetHumans

    Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly (PubMed:12785837, PubMed:24971490). Acc...

    Synonyms: FRDA
  3. Target

    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

    go.drugbank.com/bio_entities/BE0003931
    TargetHumans

    Synthesis and degradation of fructose 2,6-bisphosphate

    Synonyms: 6PF-2-K/Fru-2,6-P2ase 4, 6PF-2-K/Fru-2,6-P2ase testis-type isozyme
  4. Target

    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

    go.drugbank.com/bio_entities/BE0001073
    TargetEnzymeHumans

    Synthesis and degradation of fructose 2,6-bisphosphate

    Synonyms: 6PF-2-K/Fru-2,6-P2ase 1, 6PF-2-K/Fru-2,6-P2ase liver isozyme
  5. Target

    NADPH-flavin oxidoreductase

    go.drugbank.com/bio_entities/BE0002629
    TargetVibrio harveyi

    Catalyzes the NADPH-dependent reduction of FMN to FMNH(2). Involved in bioluminescence by providing FMNH(2) to luciferase.

    Synonyms: FRP
  6. Target

    Serine/threonine-protein kinase ATR

    go.drugbank.com/bio_entities/BE0010060
    TargetHumans

    Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, Pu...

    Synonyms: FRAP-related protein 1
  7. Target

    Vascular endothelial growth factor receptor 1

    go.drugbank.com/bio_entities/BE0000029
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage fun...

    Synonyms: FRT, Tyrosine-protein kinase FRT
  8. Target

    Folate receptor gamma

    go.drugbank.com/bio_entities/BE0000652
    TargetHumans

    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate

    Synonyms: FR-gamma
  9. Target

    Folate receptor

    go.drugbank.com/bio_entities/BE0010260
    TransporterTargetHumans

    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed...

    Synonyms: FR-alpha, FR-beta
  10. Target

    Folate receptor beta

    go.drugbank.com/bio_entities/BE0000271
    TargetTransporterHumans

    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly a...

    Synonyms: FR-beta