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Displaying results 1 - 10 of 11 in total
  1. Target

    Neutral alpha-glucosidase AB

    go.drugbank.com/bio_entities/BE0004698
    TargetEnzymeHumans

    Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polyc...

    Polypeptides: Neutral alpha-glucosidase AB
  2. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:1840367...

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  3. Target

    Tyrosinase

    go.drugbank.com/bio_entities/BE0000252
    TargetEnzymeHumans

    This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production fro...

    Synonyms: LB24-AB, SK29-AB
  4. Target

    Neuronal Acetylcholine (nACh) Receptor Subunits

    go.drugbank.com/bio_entities/BE0009927
    TargetHumans

    Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). … Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity)

    Synonyms: NACHR alpha-10, NACHR alpha-9
  5. Target

    Neuronal acetylcholine receptor subunit alpha-10

    go.drugbank.com/bio_entities/BE0000411
    TargetHumans

    acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR … Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric

    Synonyms: NACHR alpha-10
  6. Target

    Neuronal acetylcholine receptor subunit alpha-9

    go.drugbank.com/bio_entities/BE0002343
    TargetHumans

    receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR … Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric

    Synonyms: NACHR alpha-9
  7. Target

    Na(+)/citrate cotransporter

    go.drugbank.com/bio_entities/BE0008677
    TransporterHumans

    High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways (PubMed:12445824, PubMed:12826022, PubMed:26324167, PubMed:26384929, PubMed:30054523, PubMe...

    Synonyms: NACT
  8. Target

    Epithelial sodium channel subunit delta

    go.drugbank.com/bio_entities/BE0000495
    TargetHumans

    Potential alternative pore-forming subunit of the epithelial sodium channel (ENaC), capable of replacing the alpha/SCNN1A subunit, creating a more active channel with distinct properties (PubMed:16423824, PubMed:19520916, PubMed:22505667...

    Synonyms: Delta-NaCH
  9. Target

    Epithelial sodium channel subunit beta

    go.drugbank.com/bio_entities/BE0000024
    TargetTransporterHumans

    This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7762608, PubMed:9792722). ENaC ...

    Synonyms: Beta-NaCH
  10. Target

    Epithelial sodium channel subunit gamma

    go.drugbank.com/bio_entities/BE0000497
    TargetTransporterHumans

    This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7550319, PubMed:7762608, PubMed...

    Synonyms: Gamma-NaCH