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NACHT, LRR and PYD domains-containing protein 3
go.drugbank.com/bio_entities/BE0010347TargetHumansSensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:1840367...
Polypeptides: NACHT, LRR and PYD domains-containing protein 3Neuronal Acetylcholine (nACh) Receptor Subunits
go.drugbank.com/bio_entities/BE0009927TargetHumansHypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). … Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity)
Synonyms: NACHR alpha-10, NACHR alpha-9Serine repeat antigen 5
go.drugbank.com/bio_entities/BE0009196TargetPlasmodium falciparumPolypeptides: Serine repeat antigen 5Baculoviral IAP repeat-containing protein 3
go.drugbank.com/bio_entities/BE0010674TargetHumansMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 u...
Polypeptides: Baculoviral IAP repeat-containing protein 3Baculoviral IAP repeat-containing protein 2
go.drugbank.com/bio_entities/BE0010675TargetHumansMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ...
Polypeptides: Baculoviral IAP repeat-containing protein 2Baculoviral IAP repeat-containing protein 5
go.drugbank.com/bio_entities/BE0003408TargetHumansMultitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CP...
Polypeptides: Baculoviral IAP repeat-containing protein 5Baculoviral IAP repeat-containing protein 7
go.drugbank.com/bio_entities/BE0010707TargetHumansApoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubM...
Polypeptides: Baculoviral IAP repeat-containing protein 7Baculoviral IAP repeat-containing protein 1
go.drugbank.com/bio_entities/BE0010810TargetHumansAnti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasi...
Polypeptides: Baculoviral IAP repeat-containing protein 1Leucine-rich repeat-containing G protein-coupled receptor 5
go.drugbank.com/bio_entities/BE0010835TargetHumansReceptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with ph...
Polypeptides: Leucine-rich repeat-containing G protein-coupled receptor 5Leucine-rich repeat serine/threonine-protein kinase 2
go.drugbank.com/bio_entities/BE0009457TargetHumansSerine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:2185...
Polypeptides: Leucine-rich repeat serine/threonine-protein kinase 2