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Displaying results 1 - 10 of 11 in total
  1. Target

    Short transient receptor potential channel 4

    go.drugbank.com/bio_entities/BE0020751
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185). Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314). For...

    Synonyms: hTrp4, hTrp-4
  2. Target

    Short transient receptor potential channel 5

    go.drugbank.com/bio_entities/BE0021113
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with...

    Synonyms: hTRP5, hTRP-5
  3. Target

    4-hydroxy-tetrahydrodipicolinate reductase

    go.drugbank.com/bio_entities/BE0001983
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.

    Synonyms: HTPA reductase
  4. Target

    4-hydroxy-tetrahydrodipicolinate synthase

    go.drugbank.com/bio_entities/BE0001460
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

    Synonyms: HTPA synthase
  5. Target

    4-hydroxy-tetrahydrodipicolinate reductase

    go.drugbank.com/bio_entities/BE0001986
    TargetEscherichia coli (strain K12)

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Can use both NADH and NADPH as a reductant, with NADH being twice as effective as NADPH.

    Synonyms: HTPA reductase
  6. Target

    ATP-dependent protease ATPase subunit HslU

    go.drugbank.com/bio_entities/BE0003289
    TargetShigella flexneri

    ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. Hsl...

    Synonyms: htpI
  7. Target

    SEC14-like protein 2

    go.drugbank.com/bio_entities/BE0000256
    TargetTransporterCarrierHumans

    Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrieno...

    Synonyms: hTAP
  8. Target

    Inositol-3-phosphate synthase 1

    go.drugbank.com/bio_entities/BE0004496
    TargetHumans

    Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all...

    Synonyms: hIPS
  9. Target

    Sodium-dependent serotonin transporter

    go.drugbank.com/bio_entities/BE0000749
    TargetTransporterHumans

    Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellula...

    Synonyms: HTT
  10. Target

    Aldo-keto reductase family

    go.drugbank.com/bio_entities/BE0009802
    EnzymeHumans

    Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078)

    Synonyms: hTSP