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Lymphocyte antigen 75
go.drugbank.com/bio_entities/BE0010744TargetHumansActs as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes
Polypeptides: Lymphocyte antigen 75Synonyms: Ly-75NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
go.drugbank.com/bio_entities/BE0000493TargetHumansCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:3155...
Polypeptides: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialHeat shock protein 75 kDa, mitochondrial
go.drugbank.com/bio_entities/BE0014134TargetHumansChaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the bala...
Polypeptides: Heat shock protein 75 kDa, mitochondrialSynonyms: HSP 75Type II inositol 1,4,5-trisphosphate 5-phosphatase
go.drugbank.com/bio_entities/BE0004437TargetHumansRegulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), ...
Synonyms: 75 kDa inositol polyphosphate-5-phosphataseChemotaxis protein CheY
go.drugbank.com/bio_entities/BE0002023TargetEscherichia coli (strain K12)In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar … Overexpression of CheY in association with MotA and MotB improves motility of a ycgR disruption, suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein
Polypeptides: Chemotaxis protein CheYChemotaxis protein CheA
go.drugbank.com/bio_entities/BE0001431TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).
Polypeptides: Chemotaxis protein CheATransitional endoplasmic reticulum ATPase
go.drugbank.com/bio_entities/BE0004572TargetHumansNecessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to...
Synonyms: 15S Mg(2+)-ATPase p97 subunitRNA-binding protein FUS
go.drugbank.com/bio_entities/BE0010383TargetHumansDNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-...
Synonyms: 75 kDa DNA-pairing proteinNuclear receptor coactivator 2
go.drugbank.com/bio_entities/BE0003740TargetHumansTranscriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-ter...
Synonyms: Class E basic helix-loop-helix protein 755,6-dihydroxyindole-2-carboxylic acid oxidase
go.drugbank.com/bio_entities/BE0010503TargetHumansPlays a role in melanin biosynthesis (PubMed:16704458, PubMed:22556244, PubMed:23504663). Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ...
Synonyms: Glycoprotein 75