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Displaying results 1 - 10 of 1825 in total
  1. Target

    Tryptophan 5-hydroxylase 1

    go.drugbank.com/bio_entities/BE0000121
    TargetEnzymeHumans

    Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis

    Polypeptides: Tryptophan 5-hydroxylase 1Synonyms: Tryptophan 5-monooxygenase 1
  2. Target

    5-hydroxytryptamine receptor 1

    go.drugbank.com/bio_entities/BE0004958
    TargetHumans

    Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed:18476671, PubMed:20363322, PubMed:20945968). … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).

    Polypeptides: 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1BSynonyms: 5-HT1A, 5-HT-1A
  3. Target

    Inosine-5'-monophosphate dehydrogenase 1

    go.drugbank.com/bio_entities/BE0000761
    TargetEnzymeHumans

    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays

    Polypeptides: Inosine-5'-monophosphate dehydrogenase 1Synonyms: IMPD 1, IMPDH 1
  4. Target

    DNA (cytosine-5)-methyltransferase 1

    go.drugbank.com/bio_entities/BE0000892
    TargetHumans

    DNA methyltransferase that methylates CpG residues (PubMed:17200670, PubMed:18754681, PubMed:21745816, PubMed:26070743). Preferentially methylates hemimethylated DNA (PubMed:21745816, PubMed:26070743). Associates with DNA replication sit...

    Polypeptides: DNA (cytosine-5)-methyltransferase 1Function: DNA (cytosine-5-)-methyltransferase activity
  5. Target

    Sphingosine 1-phosphate receptor 5

    go.drugbank.com/bio_entities/BE0002432
    TargetHumans

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

    Polypeptides: Sphingosine 1-phosphate receptor 5Synonyms: S1P receptor 5, Sphingosine 1-phosphate receptor Edg-8
  6. Target

    2'-5'-oligoadenylate synthase 1

    go.drugbank.com/bio_entities/BE0004585
    TargetHumans

    Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms (PubMed:40010341). … Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent

    Polypeptides: 2'-5'-oligoadenylate synthase 1Synonyms: (2-5')oligo(A) synthase 1, 2-5A synthase 1
  7. Target

    Cyclin-dependent kinase 5 activator 1

    go.drugbank.com/bio_entities/BE0003819
    TargetHumans

    p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex...

    Polypeptides: Cyclin-dependent kinase 5 activator 1Synonyms: Cyclin-dependent kinase 5 regulatory subunit 1, CDK5 activator 1
  8. Target

    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

    go.drugbank.com/bio_entities/BE0010803
    TargetHumans

    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating … Also, is able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3), 1D-myo-inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Synonyms: SH2 domain-containing inositol 5'-phosphatase 1, SHIP-1
  9. Target

    1-phosphatidylinositol 3-phosphate 5-kinase

    go.drugbank.com/bio_entities/BE0021269
    TargetHumans

    Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). … Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764).

    Polypeptides: 1-phosphatidylinositol 3-phosphate 5-kinaseSynonyms: Phosphatidylinositol 3-phosphate 5-kinase, Phosphatidylinositol 3-phosphate 5-kinase type III
  10. Target

    Pyrroline-5-carboxylate reductase 1, mitochondrial

    go.drugbank.com/bio_entities/BE0000225
    TargetHumans

    Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808

    Polypeptides: Pyrroline-5-carboxylate reductase 1, mitochondrialSynonyms: P5CR 1, P5C reductase 1