Search
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
go.drugbank.com/bio_entities/BE0004045TargetEscherichia coli (strain K12)Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Polypeptides: 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseSynonyms: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase3-oxo-5-alpha-steroid 4-dehydrogenase 2
go.drugbank.com/bio_entities/BE0000585TargetEnzymeHumansCatalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed
Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 2Synonyms: S5AR 2, SR type 2Actin-related protein 2/3 complex subunit 4
go.drugbank.com/bio_entities/BE0004254TargetHumansThe Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). … Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
Polypeptides: Actin-related protein 2/3 complex subunit 4Synonyms: Arp2/3 complex 20 kDa subunit3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
go.drugbank.com/bio_entities/BE0000059TargetEnzymeHumans3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. … The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids
Polypeptides: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2Synonyms: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II, 3-beta-HSD IIPutative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
go.drugbank.com/bio_entities/BE0001689TargetMycobacterium tuberculosisCatalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.
Polypeptides: Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseFunction: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activityProlyl 3-hydroxylase 2
go.drugbank.com/bio_entities/BE0002206TargetEnzymeHumansProlyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:18487197). … Has no activity on substrates that lack 4-hydroxyproline in the third position (PubMed:18487197)
Polypeptides: Prolyl 3-hydroxylase 2Synonyms: Myxoid liposarcoma-associated protein 42-keto-3-deoxygluconokinase
go.drugbank.com/bio_entities/BE0003107TargetThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)Polypeptides: 2-keto-3-deoxygluconokinaseSynonyms: 2-keto-3-deoxy-gluconate kinase, 3-deoxy-2-oxo-D-gluconate kinaseProlyl 4-hydroxylase subunit alpha-2
go.drugbank.com/bio_entities/BE0002253TargetHumansCatalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins
Polypeptides: Prolyl 4-hydroxylase subunit alpha-2Synonyms: 4-PH alpha-2, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2Phosphatidylinositol 4-kinase type 2-beta
go.drugbank.com/bio_entities/BE0008985TargetHumansTogether with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosom...
Polypeptides: Phosphatidylinositol 4-kinase type 2-betaSynonyms: Phosphatidylinositol 4-kinase type II-betaTaste receptor type 2 member 4
go.drugbank.com/bio_entities/BE0020472TargetHumansGustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.
Polypeptides: Taste receptor type 2 member 4