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Displaying results 1 - 10 of 42 in total
  1. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Polypeptides: Melanoma antigen preferentially expressed in tumors
  2. Target

    Membrane protein involved in aromatic hydrocarbon degradation

    go.drugbank.com/bio_entities/BE0003979
    TargetPseudomonas putida (strain F1 / ATCC 700007)

    Polypeptides: Membrane protein involved in aromatic hydrocarbon degradation
  3. Target

    Immunoglobulin lambda variable 3-21

    go.drugbank.com/bio_entities/BE0009079
    TargetHumans

    V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). … Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).

    Synonyms: Ig lambda chain V-V region DEL
  4. Target

    Thyroxine 5-deiodinase

    go.drugbank.com/bio_entities/BE0009333
    TargetEnzymeHumans

    Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722

    Synonyms: Type 3 DI
  5. Target

    Diadenosine hexaphosphate hydrolase

    go.drugbank.com/bio_entities/BE0002822
    TargetThermus thermophilus

    Specifically hydrolyzes (di)adenosine polyphosphates but not ATP or diadenosine triphosphate, generating ATP as the product.

    Synonyms: ATP-generating (di)nucleotide polyphosphate hydrolase
  6. Target

    Type II iodothyronine deiodinase

    go.drugbank.com/bio_entities/BE0009855
    EnzymeTargetHumans

    Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722

    Synonyms: Type 2 DI
  7. Target

    Type I iodothyronine deiodinase

    go.drugbank.com/bio_entities/BE0009854
    EnzymeTargetHumans

    Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:32718224, PubMed:18821722).

    Synonyms: Type 1 DI
  8. Target

    Band 3 anion transport protein

    go.drugbank.com/bio_entities/BE0012390
    TransporterTargetHumans

    Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307)

    Synonyms: DI
  9. Target

    Interferon-inducible protein AIM2

    go.drugbank.com/bio_entities/BE0011287
    TargetHumans

    Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed: … Also acts as a regulator of neurodevelopment via its role in the DNA damage response: acts by promoting neural cell death in response to DNA damage in the developing brain, thereby purging genetically

    Synonyms: Absent in melanoma 2
  10. Target

    GTP-binding protein Rheb

    go.drugbank.com/bio_entities/BE0004594
    TargetHumans

    In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059) … In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change

    Synonyms: Ras homolog enriched in brain