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Displaying results 1 - 10 of 30 in total
  1. Drug

    Simvastatin

    go.drugbank.com/drugs/DB00641
    ApprovedInvestigational

    Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. … [A181087, A181406] Simvastatin and other drugs from the statin class of medications including [atorvastatin], [pravastatin], [rosuvastatin], [fluvastatin], and [lovastatin] are considered first-line

    Synonyms: Simvastatin, SimvastatinaMixtures: Ezetimibe and Simvastatin, Ezetimibe and Simvastatin
  2. Drug

    Acetyl simvastatin

    go.drugbank.com/drugs/DB14648
    Experimental

    Synonyms: Acetyl simvastatin, Simvastatin acetate
  3. Pathway

    Simvastatin Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174691
    Metabolic

    Metabolites of Simvastatin are predicted with biotransformer.

    Drugs: Simvastatin · Mesoheme
  4. Pathway

    Simvastatin Action Pathway

    smpdb.ca/view/SMP0000082
    Drug action

    Simvastatin, the methylated form of lovastatin, is an inactive lactone that is metabolized in vivo to β,δ-dihydroxy acid, its most potent metabolite. … The simvastatin hydroxy acid inhibits cholesterol synthesis via the mevalonate pathway by competitively inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.

    Drugs: Cholecalciferol · ATP · Simvastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more
  5. Pathway

    Simvastatin Action Pathway (New)

    smpdb.ca/view/SMP0124578
    Drug action

    Reported side effects of Simvastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain). … Simvastatin is a well-tolerated orally-administered synthetic statin that reduces total cholesterol levels, low-density lipoprotein (LDL)-cholesterol, triglyceride, and very-low-density lipoprotein (VLDL

    Drugs: Simvastatin · Calcium · Zinc · Cholesterol
  6. Drug

    Ezetimibe

    go.drugbank.com/drugs/DB00973
    ApprovedInvestigational

    Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in ...

    Mixtures: Ezetimibe and Simvastatin, Ezetimibe and SimvastatinCategories: simvastatin and ezetimibe
  7. Indication

    History of stroke or other cerebrovascular disease cardiovascular event

    go.drugbank.com/conditions/DBCOND0122341
    Drugs: Simvastatin
  8. Indication

    History of coronary heart disease Cardiovascular Event

    go.drugbank.com/conditions/DBCOND0022047
    Drugs: Simvastatin
  9. Indication

    Peripheral Angiopathy

    go.drugbank.com/conditions/DBCOND0074342
    Drugs: Naftidrofuryl · Simvastatin
  10. Drug

    Lapaquistat

    go.drugbank.com/drugs/DB16215
    Investigational

    Lapaquistat is under investigation in clinical trial NCT00256178 (Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia.).