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Displaying drugs 476 - 500 of 13773 in total

Interferon alfa-n3

Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
Approved
Investigational
Matched Description: … Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms …

Oteracil

Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy. Approved by the European Medicines Agency (EMA) in March 2011, Oteracil is available in combination with DB09257 and DB09256 within the commercially available product "Teysuno". The main active ingredient in Teysuno is DB09256,...
Approved
Matched Description: … The main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic ... able to insert itself into strands of DNA and RNA, thereby halting the replication process necessary for ... Approved by the European Medicines Agency (EMA) in March 2011, Oteracil is available in combination with …

Calcium glubionate anhydrous

Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Approved
Matched Description: … levels in people who do not get enough calcium from their diets. ... Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium …

Verapamil

Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs...
Approved
Matched Description: … Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, ... arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in ... [A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Daprodustat

Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … [A254172] In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia. ... [A254157] A phase 3 clinical trial (NCT02879305) found that in patients with CKD undergoing dialysis, ... Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that …

Ciclopirox

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.
Approved
Investigational
Matched Description: … Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a ... synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. ... In particular, the agent is especially effective in treating Tinea versicolor. …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Octocrylene

Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin...
Approved
Investigational
Matched Description: … Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and ... Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing ... However, the use of this chemical doesn’t just stop with sunscreen for face and arms, but can extend …
Matched Mixtures name: … Hope In A Jar Broad Spectrum SPF 25 Sunscreen and Moisturizer for All Skin Types ... Hope In A Jar SPF 25 ... Renewed Hope In A Jar SPF 30 …

Polidocanol

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural...
Approved
Matched Description: … The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization ... in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity ... (n) of approximately 9 and a mean molecular weight of approximately 600. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Sclerosing Agents for Local Injection …

Berotralstat

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat is strictly used to...
Approved
Matched Description: … Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary ... [L26661] It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the ... FDA on December 3, 2020, as the first once-daily oral therapy to prevent angioedema attacks of HAE in …
Matched Categories: … Drugs Used in Hereditary Angioedema …

Demeclocycline

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Approved
Matched Description: … Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer ... A tetracycline analog having a 7-chloro and a 6-methyl. …
Matched Categories: … Antibiotics for Topical Use ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Pegaptanib

Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.
Approved
Investigational
Matched Description: … Pegaptanib is a polynucleotide aptamer. ... Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces …
Matched Categories: … Vascular Endothelial Growth Factor A …

Rozanolixizumab

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange. It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly generalized myasthenia...
Approved
Investigational
Matched Description: … [A260207] AChR is vital for signal transduction in the neuromuscular junctions (NMJ) by generating ... [A260177] It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly ... [L47122] In June 2023, Rozanolixizumab-noli was approved by the FDA under Priority Review for the treatment …

Sulconazole

Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis infections.[L44592,L44597] Sulconazole appears to be effective...
Approved
Matched Description: … Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream ... [L44592,L44597] Sulconazole appears to be effective and well-tolerated in the treatment of superficial ... derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Ambenonium

Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.
Approved
Matched Description: … Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. …

Tovorafenib

Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. It was granted accelerated approval by the FDA, making it the first FDA approval of a systemic therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements. BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation,...
Approved
Investigational
Matched Description: … therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements. ... [L50587] BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation, and differentiation ... Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. …

Florbetapir (18F)

Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Description: … that plays a key role in Alzheimer's Disease pathogenesis. ... who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline. ... Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography (PET) imaging …

Pyrantel

Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm infections including ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis . Pyrantel was initially described in 1965 by researchers from Pfizer who sought cyclic amidines with suitable pharmacokinetic properties (specifically, duration of action) for use...
Approved
Vet approved
Matched Description: … Pyrantel is mainly available in formulations for dogs and cats as the embonate salt, containing a 34.7% ... Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm ... pharmacokinetic properties (specifically, duration of action) for use as an anthelmintic drug. …
Matched Mixtures name: … Heartgard Plus Chewable Tablet for Dogs - Up to 25 lbs ... Heartgard Plus Chewable Tablet for Dogs - 26 - 50 lbs ... Heartgard Plus Chewable Tablet for Dogs - 51 - 100 lbs …

Oxyquinoline

Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.
Approved
Vet approved
Matched Description: … It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products. ... Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and …
Matched Mixtures name: … INDIO (111-IN) OSSINA CURIUM NETHERLANDS …
Matched Categories: … Antiinfectives and Antiseptics for Local Oral Treatment …

Cefixime

Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis,...
Approved
Investigational
Matched Description: … [A263026] However, cefixime is not recommended as a first-line of treatment for uncomplicated urogenital ... [A263031] Cefixime was first approved in the United States in 1986.[L49293] ... Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Capecitabine

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Approved
Investigational
Matched Description: … Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor ... Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast …
Matched Categories: … Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index …

Ivosidenib

Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivosidenib was granted accelerated approval by the FDA...
Approved
Investigational
Matched Description: … a positive opinion of ivosidenib and recommended it be granted marketing authorization for the treatment ... Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. ... [L48781] In February 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Phenyl salicylate

Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in DB00945 ). Phenyl salicylate may...
Approved
Matched Description: … It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing ... Phenyl salicylate is used as a food additive in the USA [L2479]. ... salicylate (found in [DB00945] ). …

Lanthanum carbonate

Lanthanum carbonate is a phosphate binder marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse effects. It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by binding to...
Approved
Matched Description: … It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by ... binding to dietary phosphate and preventing its absorption in the intestine. ... Lanthanum carbonate is a phosphate binder marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Crizotinib

Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers...
Approved
Investigational
Matched Description: … Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase ... treating NSCLC in patients with this type of rearrangement. ... [A250785] Crizotinib was the first-in-class drug used to treat ALK-positive tumors. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Boric acid

Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes . It...
Approved
Matched Description: … Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical ... in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes ... Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Displaying drugs 476 - 500 of 13773 in total