Displaying drugs 776 - 800 of 11536 in total
Ezogabine
Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy....
Approved
Investigational
Matched Description: … It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED ... Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. …
Cefradine
A semi-synthetic cephalosporin antibiotic.
Approved
Matched Description: … A semi-synthetic cephalosporin antibiotic. …
Acer saccharum pollen
Acer saccharum pollen is the pollen of the Acer saccharum plant. Acer saccharum pollen is mainly used in allergenic testing.
Approved
Acrothecium robustum
Acrothecium robustum is a fungus which can provoke allergic reactions. Acrothecium robustum extract is used in allergenic testing.
Approved
Matched Description: … Acrothecium robustum is a fungus which can provoke allergic reactions. …
Damoctocog alfa pegol
In recent years, various extended half-life factor VIII and factor IX preparations have been studied and gained approval. In order to extend half-lives, techniques such as fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification have been utilized. Also known as, BAY94-9027,...
Approved
Investigational
Matched Description: … to reduce the number of infusions necessary to prevent bleeds in patients diagnosed with Haemophilia A. ... [L4576,A38909,Label] This product has been engineered by Bayer[L4576] and a biological license application ... [A38907]
Also known as, BAY94-9027, Damoctocog alfa pegol is a longer-acting Factor VIII therapy formulated …
Turoctocog alfa pegol
Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019.
Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Description: … A as it ultimately provides a less burdensome and more convenient dosing regimen for patients that is ... Turoctocog alfa pegol is a pegylated version of [turoctocog alfa]. ... Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor …
Amaranthus retroflexus whole
Amaranthus retroflexus whole allergenic extract is used in allergenic testing.
Approved
Potassium perchlorate
Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers...
Approved
Investigational
Matched Description: … It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. ... The use of potassium perchlorate as a component in sealing gaskets for food containers has been revoked ... The therapeutic use of potassium perchlorate in thyroid disorders has been ceased due to a high risk …
Topiramate
Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy...
Approved
Matched Description: … Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. ... chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. ... [A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel …
Nabilone
Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Description: … for such a wide variety of medical conditions. ... Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. ... (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. …
Glimepiride
First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in accordance with progressive...
Approved
Matched Description: … First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class ... Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by ... Compared to [glipizide], another second SU drug, glimepiride has a longer duration of action. …
Ropivacaine
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Approved
Matched Description: … It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the …
Perindopril
Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor ... Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …
Moxonidine
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown...
Approved
Investigational
Matched Description: … Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild …
Chlorpropamide
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class...
Approved
Investigational
Diamorphine
Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under...
Approved
Illicit
Investigational
Matched Description: … It is a controlled substance (opium derivative) listed in the U.S. ... Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. ... However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom. …
Belzutifan
Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau (VHL) disease-associated cancers. The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a key player in the growth of certain cancers. Initially considered to be undruggable,...
Approved
Investigational
Matched Description: … HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a ... [L36105] Initially considered to be undruggable, a binding pocket was eventually discovered in the HIF ... to the initial development of belzutifan (at the time called PT2977), which was further developed by a …
Cyclacillin
A cyclohexylamido analog of penicillanic acid.
Approved
Matched Description: … A cyclohexylamido analog of penicillanic acid. …
Mitapivat
Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red...
Approved
Investigational
Matched Description: … Mitapivat is a novel, first-in-class pyruvate kinase activator. ... It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival ... first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a …
Corydalis ambigua tuber
Corydalis ambigua tuber is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Corydalis ambigua tuber is a plant/plant extract used in some OTC (over-the-counter) products. …
Palovarotene
Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … It first garnered interest as a potential treatment for emphysema but was eventually recognized as a ... ], which are derivatives of [vitamin A]. ... [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive …
Levamlodipine
Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlodipine and levamlodipine may be used interchangeably as both...
Approved
Investigational
Matched Description: … Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], ... [L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine …
Terbutaline
Terbutaline was first synthesized in 1966 and described in the literature in the late 1960s and early 1970s. It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.[A230333,L32093,L32098]
Terbutaline was granted FDA approval on 25 March 1974.
Approved
Matched Description: … [A230328] It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients. …
Tetradecyl hydrogen sulfate (ester)
Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins .
Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Description: … 30% incidence of post-sclerosis pigmentation that resolved within a few months [L2035]. ... sulfate has been widely used since the 1950s, and in 1978 the first successful report of injecting a ... surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a …
Displaying drugs 776 - 800 of 11536 in total