Displaying drugs 401 - 425 of 8033 in total
Ropinirole
Ropinirole, also known as ReQuip, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], . It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first...
Approved
Investigational
Matched Description: … In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing ... Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease ... In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless …
Dronedarone
Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate control, rhythm control, prevention...
Approved
Matched Description: … of dronedarone. ... It is managed by rate control, rhythm control, prevention of thromboembolic events, and treatment of ... [A186071] It meets criteria of all four Vaughan Williams antiarrhythmic drug classes by blocking sodium …
Cysteamine
Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. A defect in cystinosin function is followed by cystine accumulation throughout the body, especially the eyes and kidneys. Several preparations of cysteamine exist...
Approved
Investigational
Matched Description: … [A218721]
Several preparations of cysteamine exist for the treatment of cystinosis manifestations, ... mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of ... Marketed by Recordati Rare Diseases Inc., CYSTADROPS® reduce the burden of multiple frequent medications …
Sodium glycerophosphate
Sodium glycerophosphate is one of several glycerophosphate salts. It is used clinically to treat or prevent low phosphate levels [FDA Label]. Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body . The extent of this reaction is dependent on the activity of serum alkaline phosphatases.
Approved
Matched Description: … The extent of this reaction is dependent on the activity of serum alkaline phosphatases. ... Sodium glycerophosphate is one of several glycerophosphate salts. …
Sebelipase alfa
The lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism of lipids, and its absence or deficiency results in the accumulation of lipids in various organs. This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption secondary...
Approved
Investigational
Matched Description: … lipids, and its absence or deficiency results in the accumulation of lipids in various organs. ... lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism of ... This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption …
Calcium chloride
Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice...
Approved
Matched Description: … Calcium chloride is an ionic compound of calcium and chlorine. ... Because of its hygroscopic nature, it must be kept in tightly-sealed containers. ... It can be produced directly from limestone, but large amounts are also produced as a by-product of the …
Rifamycin
Rifamycin is the prime member of the rifamycin family which are represented by drugs that are a product of fermentation from the gram-positive bacterium Amycolatopsis mediterranei, also known as Streptomyces mediterranei. The parent compound of rifamycin was rifamycin B which was originally obtained as a main product in the presence...
Approved
Investigational
Matched Description: … presence of diethylbarburitic acid. ... SV there was the first antibiotic used intravenously for the treatment of tuberculosis. ... Rifamycin is the prime member of the rifamycin family which are represented by drugs that are a product …
Matched Categories: … Drugs for Treatment of Tuberculosis …
Matched Categories: … Drugs for Treatment of Tuberculosis …
Ethinylestradiol
Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering. It was developed in an effort to create an estrogen with greater oral bioavailability. These properties were achieved by the substitution of an ethinyl group at carbon 17 of estradiol. Ethinylestradiol soon replaced mestranol in...
Approved
Matched Description: … [A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Cefotaxime
Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Approved
Matched Description: … In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. …
Epoprostenol
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Approved
Fluticasone furoate
Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label] . Fluticasone furoate was first approved in 2007 .
Approved
Aztreonam
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Approved
Matched Description: … It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges …
Fluorouracil
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Description: … It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid …
Mycophenolate mofetil
Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as Cyclosporine and corticosteroids to prevent organ rejection after hepatic, renal, and cardiac transplants. It is...
Approved
Investigational
Matched Description: … effects associated with the administration of MPA. ... nephritis and other complications of autoimmune diseases. ... as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). …
Cefaclor
Semisynthetic, broad-spectrum antibiotic derivative of cephalexin.
Approved
Matched Description: … Semisynthetic, broad-spectrum antibiotic derivative of cephalexin. …
Finerenone
Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization due to heart failure in adults with chronic kidney disease associated with type II diabetes mellitus.[A236519,L34739] Patients with kidney...
Approved
Investigational
Matched Description: … Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of …
Brolucizumab
Brolucizumab, also known as RTH258 or ESBA1008, is a monoclonal antibody indicated to treat neovascular age related macular degeneration. Brolucizumab was granted FDA approval in October 2019.
Approved
Investigational
Ranibizumab
Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology of age-related macular degeneration.[A2301, L38978] Ranibizumab is used to treat various ocular disorders with abnormal growth of blood vessels, such as neovascular...
Approved
Matched Description: … only biosimilar drug of ranibizumab available in Canada. ... vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology of ... The development of ranibizumab first began after [bevacizumab], another anti-VEGF anticancer drug, was …
Talazoparib
Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was approved by Health Canada...
Approved
Investigational
Matched Description: … Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes ... [L47301] Talazoparib is currently used in the treatment of BRCA-mutated breast cancer and HRR-mutated …
Equine Botulinum Neurotoxin G Immune FAB2
Equine Botulinum Neurotoxin G Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype G. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes G in...
Approved
Experimental
Investigational
Matched Description: … Equine Botulinum Neurotoxin G Immune FAB2 is composed of a mixture of immune globulin fragments purified ... from plasma of horses that were previously immunized with botulinum toxin serotype G. ... It is intravenously administered for the treatment of symptomatic botulism following documented or suspected …
Equine Botulinum Neurotoxin A Immune FAB2
Equine Botulinum Neurotoxin A Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype A. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes A in...
Approved
Experimental
Investigational
Matched Description: … Equine Botulinum Neurotoxin A Immune FAB2 is composed of a mixture of immune globulin fragments purified ... from plasma of horses that were previously immunized with botulinum toxin serotype A. ... It is intravenously administered for the treatment of symptomatic botulism following documented or suspected …
Equine Botulinum Neurotoxin F Immune FAB2
Equine Botulinum Neurotoxin F Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype F. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes F in...
Approved
Experimental
Investigational
Matched Description: … Equine Botulinum Neurotoxin F Immune FAB2 is composed of a mixture of immune globulin fragments purified ... from plasma of horses that were previously immunized with botulinum toxin serotype F. ... It is intravenously administered for the treatment of symptomatic botulism following documented or suspected …
Equine Botulinum Neurotoxin D Immune FAB2
Equine Botulinum Neurotoxin D Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype D. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes D in...
Approved
Experimental
Investigational
Matched Description: … Equine Botulinum Neurotoxin D Immune FAB2 is composed of a mixture of immune globulin fragments purified ... from plasma of horses that were previously immunized with botulinum toxin serotype D. ... It is intravenously administered for the treatment of symptomatic botulism following documented or suspected …
Equine Botulinum Neurotoxin B Immune FAB2
Equine Botulinum Neurotoxin B Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype B. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes B in...
Approved
Experimental
Investigational
Matched Description: … Equine Botulinum Neurotoxin B Immune FAB2 is composed of a mixture of immune globulin fragments purified ... from plasma of horses that were previously immunized with botulinum toxin serotype B. ... It is intravenously administered for the treatment of symptomatic botulism following documented or suspected …
Irbesartan
Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.[L7456,L7459] It can also be used as part of a combination product with hydrochlorothiazide for patients not well controlled or not expected to be well controlled on monotherapy. Unlike angiotensin converting enzyme inhibitors, ARBs are not associated...
Approved
Investigational
Matched Description: … [L7456,L7459] It can also be used as part of a combination product with [hydrochlorothiazide] for patients …
Displaying drugs 401 - 425 of 8033 in total