Calcium chloride

Identification

Summary

Calcium chloride is an ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.

Brand Names

Artiss, Bss, Bss Ophthalmic Solution, Calciject, Cardioplegic, Citrasate, Clinimix E 2.75/5, Dianeal, Dianeal Low Calcium 1.5, Dianeal Pd-2/1.5, Extraneal, Eye Stream, H.E.L.P.bicel, Hemosate Ultra, Hyperlyte, Lactated Ringers, Naturalyte, Nxstage Pureflow, Olimel, Periolimel, Phoxillum, Physioneal 40, Plasma-lyte R, Plegisol, Prismasol, Ringers, Selectbag One, Tisseel

Generic Name

Calcium chloride

DrugBank Accession Number

DB01164

Background

Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers.

Type

Small Molecule

Groups

Approved

Structure

Similar Structures

Weight: Average: 110.984
Monoisotopic: 109.900296569
Chemical Formula: CaCl₂

Synonyms

Calcio cloruro
Calcium chloride anhydrous
Calcium chloride, anhydrous
calcium(2+) chloride

External IDs

E-509
INS NO.509
INS-509

Pharmacology

Indication

For the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.

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Associated Conditions

Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Calcium is the fifth most abundant element in the body and the major fraction is in the bony structure. Calcium plays important physiological roles, many of which are poorly understood. It is essential for the functional integrity of the nervous and muscular systems. It is necessary for normal cardiac function and is one of the factors that operates in the mechanisms involved in the coagulation of blood.

Mechanism of action

Calcium chloride in water dissociates to provide calcium (Ca²⁺) and chloride (Cl^-) ions. They are normal constituents of the body fluids and are dependent on various physiological mechanisms for maintenance of balance between intake and output. For hyperkalemia, the influx of calcium helps restore the normal gradient between threshold potential and resting membrane potential.

Target	Actions	Organism
UProtein S100-A13	Not Available	Humans

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.

Route of elimination

Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Too rapid injection may produce lowering of blood pressure and cardiac syncope. Persistent hypercalcemia from overdosage of calcium is unlikely because of rapid excretion.

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Abciximab	The therapeutic efficacy of Calcium chloride can be decreased when used in combination with Abciximab.
Acebutolol	The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium chloride.
Acenocoumarol	The therapeutic efficacy of Calcium chloride can be decreased when used in combination with Acenocoumarol.
Acetyldigitoxin	Calcium chloride may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Alendronic acid	The serum concentration of Alendronic acid can be decreased when it is combined with Calcium chloride.
Alfacalcidol	The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium chloride.
Alpha-1-proteinase inhibitor	Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Calcium chloride.
Alteplase	The therapeutic efficacy of Calcium chloride can be decreased when used in combination with Alteplase.
Aminocaproic acid	The risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Calcium chloride.
Amiodarone	The therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium chloride.

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Food Interactions

No interactions found.

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Calcium chloride dihydrate	M4I0D6VV5M	10035-04-8	LLSDKQJKOVVTOJ-UHFFFAOYSA-L
Calcium chloride hexahydrate	1D898P42YW	7774-34-7	Not applicable

Active Moieties

Name	Kind	UNII	CAS	InChI Key
Calcium	unknown	SY7Q814VUP	7440-70-2	OYPRJOBELJOOCE-UHFFFAOYSA-N
Chloride ion	ionic	Q32ZN48698	16887-00-6	VEXZGXHMUGYJMC-UHFFFAOYSA-M
Calcium cation	ionic	2M83C4R6ZB	14127-61-8	BHPQYMZQTOCNFJ-UHFFFAOYSA-N

International/Other Brands

Jarcal / LiquiCal-D 400

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Calciject Inj 100mg/ml	Liquid	100 mg / mL	Intravenous	Omega Laboratories Ltd	1990-12-31	Not applicable
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous	General Injectables & Vaccines	2010-03-01	2014-02-01
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous	Cardinal Health	2011-03-09	2019-11-30
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous; Intraventricular	HF Acquisition Co LLC, DBA HealthFirst	2018-09-13	Not applicable
Calcium Chloride	Injection	100 mg/1mL	Parenteral	Amphastar Pharmaceuticals, Inc.	1973-05-01	2009-12-31
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous; Intraventricular	Hospira, Inc.	2006-01-24	Not applicable
Calcium Chloride	Injection	100 mg/1mL	Intravenous; Intraventricular	Medical Purchasing Solutions, Llc	1973-05-01	Not applicable
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous	Cardinal Health	2011-06-14	2014-02-28
Calcium Chloride	Injection	100 mg/1mL	Parenteral	Amphastar Pharmaceuticals, Inc.	2000-06-01	2013-01-25
Calcium Chloride	Injection	100 mg/1mL	Intravenous	Amneal-Agila, LLC	2013-05-31	2017-12-31

Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Calcium Chloride	Injection	100 mg/1mL	Intravenous; Intraventricular	HF Acquisition Co LLC, DBA HealthFirst	2019-12-09	Not applicable
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous	Medefil, Inc.	2019-08-22	Not applicable
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous	Civica, Inc.	2021-04-02	Not applicable
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous	Medical Purchasing Solutions, Llc	2019-08-22	Not applicable
Calcium Chloride	Injection	100 mg/1mL	Intravenous; Intraventricular	International Medication Systems, Limited	2018-07-08	Not applicable
Calcium Chloride	Injection	100 mg/1mL	Intravenous; Intraventricular	A-S Medication Solutions	2018-07-08	2019-04-30
Calcium Chloride	Injection, solution	100 mg/1mL	Intravenous	AMERICAN REGENT, INC.	2018-02-06	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP	Calcium chloride (20 mg / 100 mL) + Sodium lactate (310 mg / 100 mL) + Potassium chloride (328 mg / 100 mL) + Sodium chloride (600 mg / 100 mL)	Solution	Intravenous	Baxter Laboratories	2002-12-11	2016-07-15
5% Dextrose In Lactated Ringer's Injection	Calcium chloride (20 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Sodium lactate (310 mg / 100 mL) + Potassium chloride (30 mg / 100 mL) + Sodium chloride (600 mg / 100 mL)	Solution	Intravenous	B. Braun Medical Inc.	1993-12-31	2012-04-10
ACCUSOL 35	Calcium chloride dihydrate (0.343 g/L) + Magnesium chloride hexahydrate (0.136 g/L) + Sodium bicarbonate (12.9 g/L) + Sodium chloride (7.66 g/L)	Solution		บริษัท ซิลลิค ฟาร์มา จำกัด	2015-08-31	Not applicable
ACETAR (ACETATE RINGER'S INJECTION)	Calcium chloride dihydrate (0.02 g/100mL) + Potassium chloride (0.03 g/100mL) + Sodium acetate trihydrate (0.38 g/100mL) + Sodium chloride (0.6 g/100mL)	Solution	Intravenous	บริษัท ไทยโอซูก้า จำกัด จำกัด	1985-03-19	Not applicable
Acetate Concentrate R07376	Calcium chloride (6.432 g / L) + Dextrose, unspecified form (38.5 g / L) + Magnesium chloride (3.558 g / L) + Potassium chloride (2.609 g / L) + Sodium acetate (114.8 g / L) + Sodium chloride (204.5 g / L)	Liquid	Hemodialysis	Bdh Inc.	1995-12-31	2000-08-03
ACETATE RINGER'S INJECTION	Calcium chloride dihydrate (0.02 g/100mL) + Potassium chloride (0.03 g/100mL) + Sodium acetate trihydrate (0.38 g/100mL) + Sodium chloride (0.6 g/100mL)	Solution	Intravenous	บริษัท เอ.เอ็น.บี.ลาบอราตอรี่ (อำนวยเภสัช) จำกัด จำกัด	1989-10-05	Not applicable
Acid Concentrate (r04146)	Calcium chloride (9.477 g / L) + Acetic acid (8.846 g / L) + Dextrose, unspecified form (60.8 g / L) + Magnesium chloride (3.744 g / L) + Sodium chloride (184 g / L)	Liquid	Hemodialysis	Genpharm Ulc	1997-05-21	2004-07-30
Acid Concentrate (r04938)	Calcium chloride (9.476 g / L) + Acetic acid (8.846 g / L) + Dextrose, unspecified form (60.77 g / L) + Magnesium chloride (3.744 g / L) + Potassium chloride (5.491 g / L) + Sodium chloride (172.2 g / L)	Liquid	Hemodialysis	Genpharm Ulc	1987-12-31	2001-08-03
Acid Concentrate (r04968)	Calcium chloride (3.384 g / L) + Acetic acid (8.846 g / L) + Magnesium chloride (3.744 g / L) + Potassium chloride (5.491 g / L) + Sodium chloride (180.8 g / L)	Liquid	Hemodialysis	Genpharm Ulc	1988-12-31	2004-07-30
Acid Concentrate (r04969)	Calcium chloride (3.384 g / L) + Acetic acid (8.846 g / L) + Magnesium chloride (3.744 g / L) + Potassium chloride (2.746 g / L) + Sodium chloride (180.8 g / L)	Liquid	Hemodialysis	Genpharm Ulc	1988-12-31	2004-07-30

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
BALANCE %1,5 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA	Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %1,5 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2500 ML BIOFIN TORBA	Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %1,5 GLIKOZ 1,75 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA	Calcium chloride dihydrate (0.2573 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %1,5 GLIKOZ 1,75 MMOL / 1 KALSIYUM 2500 ML BIOFIN TORBA	Calcium chloride dihydrate (0.2573 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %2,3 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA	Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (25 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %2,3 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2500 ML BIOFIN TORBA	Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (25 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %2,3 GLIKOZ 1,75 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA	Calcium chloride dihydrate (0.2573 g/L) + D-glucose monohydrate (25 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %2,3 GLIKOZ 1,75 MMOL / 1 KALSIYUM 2500 ML BIOFIN TORBA	Calcium chloride dihydrate (0.2573 g/L) + D-glucose monohydrate (25 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %4,25 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA	Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (46.75 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable
BALANCE %4,25 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2500 ML BIOFIN TORBA	Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (46.75 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L)	Solution	Intraperitoneal	FRESENIUS MEDİKAL HİZMETLER A.Ş.	2020-08-14	Not applicable

Chemical Identifiers

UNII: OFM21057LP
CAS number: 10043-52-4
InChI Key: UXVMQQNJUSDDNG-UHFFFAOYSA-L
InChI: InChI=1S/Ca.2ClH/h;2*1H/q+2;;/p-2
IUPAC Name: calcium dichloride
SMILES: [Cl-].[Cl-].[Ca++]

References

Synthesis Reference

Silvano Grosso, Kenneth E. Nelson, "Method for preparing liquid feed supplements containing calcium chloride." U.S. Patent US3962484, issued August, 1973.

US3962484

General References

Not Available

External Links

KEGG Compound: C08130
PubChem Compound: 5284359
PubChem Substance: 46507257
ChemSpider: 23237
RxNav: 1667640
ChEBI: 3312
ChEMBL: CHEMBL1200668
PharmGKB: PA448729
RxList: RxList Drug Page
Wikipedia: Calcium_chloride

MSDS

Download (74.1 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Treatment	APD / Continuous ambulatory peritoneal dialysis therapy / Diabetes / ESRD	1
4	Completed	Treatment	Cesarean Sections / Hypotension / Pregnant State / Spinal Anaesthesia	1
4	Completed	Treatment	Chronic Kidney Disease (CKD) / Peritoneal dialysis therapy	1
4	Completed	Treatment	Coronary Artery Bypass Grafting (CABG) / Valve Surgery	1
4	Completed	Treatment	Coronary Artery Disease (CAD) / Valvular Heart Disease	1
4	Completed	Treatment	Dehydration (Physiology)	1
4	Completed	Treatment	Fluid Over-load / Postoperative Complications	1
4	Completed	Treatment	Goal Directed Fluid Therapy	1
4	Completed	Treatment	Impaired Renal Function	1
4	Completed	Treatment	Intoxication; Septic / Septic	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

American Regent
AstraZeneca Inc.
Baxter International Inc.
Cardinal Health
General Injectables and Vaccines Inc.
Hospira Inc.
J T Baker
Luitpold Pharmaceuticals Inc.
Physicians Total Care Inc.
Spectrum Pharmaceuticals

Dosage Forms

Form	Route	Strength
Solution	Hemodialysis
Solution	Hemodialysis	0.257 g/1000ml
Solution	Irrigation; Parenteral
Powder, for solution	Intraocular
Solution	Intraocular
Solution	Topical
Solution	Topical	3000 KIU/ml
Solution	Ophthalmic
Kit; solution	Intraocular
Liquid	Ophthalmic
Liquid	Intravenous	100 mg / mL
Injection, solution	Parenteral
Injection, solution, concentrate	Intravenous
Solution, concentrate	Parenteral
Injection, solution, concentrate	Intravenous; Parenteral
Injection, solution, concentrate	Intravenous; Parenteral	1 G/10ML
Injection, solution, concentrate	Intravenous; Parenteral	5 mEq/10ml
Injection, solution, concentrate	Intravenous; Parenteral	500 MG/10ML
Injection	Intravenous	100 mg/1mL
Injection	Intravenous; Intraventricular	100 mg/1mL
Injection	Parenteral	100 mg/1mL
Injection, solution	Intravenous	100 mg/1mL
Injection, solution	Intravenous	20 mg/1mL
Injection, solution	Intravenous; Intraventricular	100 mg/1mL
Powder	Hemodialysis	12.32 g / vial
Powder	Hemodialysis	3.78 g / vial
Powder	Hemodialysis	7.45 g / vial
Solution	Intravenous	100 mg / mL
Powder, for solution	Hemodialysis	12.9 g / pck
Powder, for solution	Hemodialysis	5.8 g / pck
Powder	Hemodialysis	6.1 g / pck
Powder	Hemodialysis	12.2 g / pck
Powder	Hemodialysis	7.45 g / bottle
Powder	Hemodialysis	14.9 g / bottle
Solution	Parenteral
Injection, solution	Intravenous	100 MMOL/L
Solution	Intraperitoneal	0.2573 g/l
Solution	Intraperitoneal	0.1838 g/L
Solution
Solution	Intra-arterial
Solution	Extracorporeal
Solution	Intravenous
Injection, solution	Parenteral
Solution	Intravenous	0.27 g/1000ml
Injection	Intravenous	0.027 g/100ml
Injection	Intravenous	270 mg/l
Solution	Irrigation
Solution	Intraperitoneal
Injection	Intravenous
Solution	Intraperitoneal; Irrigation
Solution	Intraperitoneal	18.3 mg/100ml
Injection, solution	Intraperitoneal
Solution	Ophthalmic	0.02 %
Solution	Intravenous	4.21 g/1000ml
Solution	Intravenous	1.98 g/1000ml
Solution	Intrathecal
Injection	Intrathecal
Solution	Parenteral
Solution	Intraperitoneal	25.7 mg/100ml
Solution	Intraperitoneal	257 mg/l
Emulsion	Parenteral
Solution, concentrate	Hemodialysis
Solution	Intravenous	0.15 g/1000ml
Aerosol, spray	Oral
Solution	Hemodialysis	7.77 g/l
Solution	Hemodialysis	6.47 g/l
Solution	Hemodialysis	8.46 g/l
Solution	Hemodialysis	8.8 g/l
Solution	Hemodialysis	8.85 g/l
Solution	Hemodialysis	9.74 g/l
Liquid	Hemodialysis
Solution	Hemodialysis	6.77 g/l
Solution	Oral
Liquid	Intraperitoneal
Solution	Hemodialysis; Intraperitoneal
Liquid	Intraocular
Injection, emulsion	Intravenous
Injection	Intravenous	2.3 g/1000ml
Injection	Intravenous	1.6 g/l
Injection	Intravenous	20 mg/100ml
Liquid	Irrigation
Solution, for slush	Irrigation
Injection	Intravenous	0.027 % w/v
Liquid	Buccal
Spray	Buccal
Injection, solution	Hemodialysis; Intravenous
Solution	Hemodialysis	1.1 g/L
Kit; solution	Intraocular; Irrigation
Injection, emulsion	Parenteral
Injection, emulsion; injection, solution	Intravenous
Emulsion	Intravenous
Injection, solution
Injection, emulsion	Intravenous	4.656 g/1000ml
Injection, emulsion	Intravenous	6.792 g/1000ml
Injection, solution, concentrate	Intravenous
Solution	Intraperitoneal	0.184 g/l
Emulsion	Intravenous	0.3 g/l
Emulsion	Intravenous	4 g
Solution	Intraocular; Ophthalmic
Solution	Intraocular; Irrigation
Solution	Extracorporeal; Intrabiliary; Intracardiac
Rinse	Dental
Emulsion	Intravenous	3 g
Solution	Intravenous	0.225 g/L
Solution	Intraperitoneal	0.507 g/l
Injection, solution	Intravenous
Injection, solution	Intra-arterial
Liquid	Intravenous
Kit	Hemodialysis
Solution	Hemodialysis; Intravenous
Solution	Hemodialysis	0.257 g/l
Kit; solution	Topical
Solution	Intravenous	0.1 g/500ml
Solution	Irrigation; Topical
Injection	Intravenous	0.33 g/1L
Irrigant	Irrigation
Injection, solution	Irrigation
Solution	Buccal; Oral; Topical
Aerosol	Oral
Spray	Oral
Powder, for solution	Topical
Injection, emulsion	Intravenous	14 g/1000ml
Injection, emulsion	Intravenous	0.28 g/1000ml
Injection	Parenteral
Solution	Intravenous	0.3675 g/1000ml
Emulsion	Intravenous	0.74 g/L
Kit	Topical
Powder	Topical
Kit; solution
Powder	Soft tissue
Solution	Intravenous; Irrigation

Prices

Unit description	Cost	Unit
SureStep Test 25 Strip Box	31.92USD	box
Calcium chloride powder	0.44USD	g
Calcium chloride 10% vial	0.18USD	ml
Calcium chloride granules	0.1USD	g
Calcium chloride 10% ampul	0.07USD	ml

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US6077836	No	2000-06-20	2017-06-20
US6248726	No	2001-06-19	2018-06-19
US7084130	No	2006-08-01	2021-11-29

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	782 °C	Not Available
water solubility	0.745 g/mL (at 20 °C)	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	21.4 mg/mL	ALOGPS
logP	1.08	ALOGPS
logP	-0.57	ChemAxon
logS	-0.71	ALOGPS
pKa (Strongest Acidic)	3.09	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol^-1	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	+	0.9445
Blood Brain Barrier	+	0.975
Caco-2 permeable	+	0.6764
P-glycoprotein substrate	Non-substrate	0.9039
P-glycoprotein inhibitor I	Non-inhibitor	0.9891
P-glycoprotein inhibitor II	Non-inhibitor	0.9866
Renal organic cation transporter	Non-inhibitor	0.9196
CYP450 2C9 substrate	Non-substrate	0.8116
CYP450 2D6 substrate	Non-substrate	0.717
CYP450 3A4 substrate	Non-substrate	0.7571
CYP450 1A2 substrate	Non-inhibitor	0.7506
CYP450 2C9 inhibitor	Non-inhibitor	0.8587
CYP450 2D6 inhibitor	Non-inhibitor	0.9306
CYP450 2C19 inhibitor	Non-inhibitor	0.8304
CYP450 3A4 inhibitor	Non-inhibitor	0.956
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9002
Ames test	Non AMES toxic	0.6808
Carcinogenicity	Carcinogens	0.764
Biodegradation	Ready biodegradable	0.6815
Rat acute toxicity	1.9786 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9433
hERG inhibition (predictor II)	Non-inhibitor	0.9634

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Targets

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Details1. Protein S100-A13

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Zinc ion binding
Specific Function: Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion doe...
Gene Name: S100A13
Uniprot ID: Q99584
Uniprot Name: Protein S100-A13
Molecular Weight: 11471.095 Da

References

Sivaraja V, Kumar TK, Rajalingam D, Graziani I, Prudovsky I, Yu C: Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J. 2006 Sep 1;91(5):1832-43. Epub 2006 Jun 9. [Article]

Drug created on June 13, 2005 13:24 / Updated on October 22, 2021 23:18

Calcium chloride

Identification

Structure for Calcium chloride (DB01164)

Pharmacology

Interactions

Products

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Clinical Trials

Pharmacoeconomics

Properties

Spectra

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References