Calcium chloride
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Identification
- Summary
Calcium chloride is an ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.
- Brand Names
- Artiss, Bss, Bss Ophthalmic Solution, Calciject, Cardioplegic, Citrasate, Clinimix E 2.75/5, Dianeal, Dianeal Low Calcium 1.5, Dianeal Pd-2/1.5, Extraneal, H.E.L.P.bicel, Hemosate Ultra, Hyperlyte, Lactated Ringers, Naturalyte, Nxstage Pureflow, Olimel, Periolimel, Phoxillum, Plasma-lyte R, Plegisol, Prismasol, Ringers, Tisseel
- Generic Name
- Calcium chloride
- DrugBank Accession Number
- DB01164
- Background
Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 110.984
Monoisotopic: 109.900296569 - Chemical Formula
- CaCl2
- Synonyms
- Calcio cloruro
- Calcium chloride anhydrous
- Calcium chloride, anhydrous
- calcium(2+) chloride
- External IDs
- E-509
- INS NO.509
- INS-509
Pharmacology
- Indication
For the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.
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- Associated Therapies
- Continuous Renal Replacement Therapy
- Electrolyte replacement
- Haemodiafiltration
- Haemofiltration
- Hemodialysis Treatment
- Irrigation therapy
- Parenteral Nutrition
- Peritoneal dialysis therapy
- Plasma Volume Replacement
- Urine alkalinization therapy
- Distension of the joints
- Extraocular irrigation
- Fluid and electrolyte maintenance therapy
- Induction of cardiac arrest
- Irrigation of the joints
- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Calcium is the fifth most abundant element in the body and the major fraction is in the bony structure. Calcium plays important physiological roles, many of which are poorly understood. It is essential for the functional integrity of the nervous and muscular systems. It is necessary for normal cardiac function and is one of the factors that operates in the mechanisms involved in the coagulation of blood.
- Mechanism of action
Calcium chloride in water dissociates to provide calcium (Ca2+) and chloride (Cl-) ions. They are normal constituents of the body fluids and are dependent on various physiological mechanisms for maintenance of balance between intake and output. For hyperkalemia, the influx of calcium helps restore the normal gradient between threshold potential and resting membrane potential.
Target Actions Organism UProtein S100-A13 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.
- Route of elimination
Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Too rapid injection may produce lowering of blood pressure and cardiac syncope. Persistent hypercalcemia from overdosage of calcium is unlikely because of rapid excretion.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcebutolol The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium chloride. Acetyldigitoxin Calcium chloride may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin. Alendronic acid The serum concentration of Alendronic acid can be decreased when it is combined with Calcium chloride. Alfacalcidol The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium chloride. Amiodarone The therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium chloride. - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Calcium chloride dihydrate M4I0D6VV5M 10035-04-8 LLSDKQJKOVVTOJ-UHFFFAOYSA-L Calcium chloride hexahydrate 1D898P42YW 7774-34-7 Not applicable - Active Moieties
Name Kind UNII CAS InChI Key Calcium cation ionic 2M83C4R6ZB 14127-61-8 BHPQYMZQTOCNFJ-UHFFFAOYSA-N Chloride ion ionic Q32ZN48698 16887-00-6 VEXZGXHMUGYJMC-UHFFFAOYSA-M Calcium unknown SY7Q814VUP 7440-70-2 OYPRJOBELJOOCE-UHFFFAOYSA-N - International/Other Brands
- Jarcal / LiquiCal-D 400
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Calciject Inj 100mg/ml Liquid 100 mg / mL Intravenous Omega Laboratories Ltd 1990-12-31 Not applicable Canada Calcium Chloride Injection, solution 100 mg/1mL Intravenous Henry Schein, Inc. 2022-01-09 Not applicable US Calcium Chloride Injection, solution 20 mg/1mL Intravenous Cantrell Drug Company 2011-03-08 Not applicable US Calcium Chloride Injection, solution 100 mg/1mL Intravenous; Intraventricular HF Acquisition Co LLC, DBA HealthFirst 2018-09-13 Not applicable US Calcium Chloride Injection 100 mg/1mL Intravenous; Intraventricular Medical Purchasing Solutions, Llc 1973-05-01 Not applicable US - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Calcium Chloride Injection 100 mg/1mL Intravenous; Intraventricular International Medication Systems, Limited 2018-07-08 Not applicable US Calcium Chloride Injection, solution 100 mg/1mL Intravenous Amneal Pharmaceuticals LLC 2024-07-17 Not applicable US Calcium Chloride Injection 100 mg/1mL Intravenous; Intraventricular A-S Medication Solutions 2018-07-08 2019-04-30 US Calcium Chloride Injection, solution 100 mg/1mL Intravenous AMERICAN REGENT, INC. 2018-02-06 Not applicable US Calcium Chloride Injection 100 mg/1mL Intravenous; Intraventricular HF Acquisition Co LLC, DBA HealthFirst 2019-12-09 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image (40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USP Calcium chloride (20 mg / 100 mL) + Sodium lactate (310 mg / 100 mL) + Potassium chloride (328 mg / 100 mL) + Sodium chloride (600 mg / 100 mL) Solution Intravenous Baxter Laboratories 2002-12-11 2016-07-15 Canada 5% Dextrose In Lactated Ringer's Injection Calcium chloride (20 mg / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Sodium lactate (310 mg / 100 mL) + Potassium chloride (30 mg / 100 mL) + Sodium chloride (600 mg / 100 mL) Solution Intravenous B. Braun Medical Inc. 1993-12-31 2012-04-10 Canada ACCUSOL 35 Calcium chloride dihydrate (0.343 g/L) + Magnesium chloride hexahydrate (0.136 g/L) + Sodium bicarbonate (12.9 g/L) + Sodium chloride (7.66 g/L) Solution บริษัท ซิลลิค ฟาร์มา จำกัด 2015-08-31 Not applicable Thailand Accusol 35 Potassium 4 mmol/l Solution for Haemofiltration, Haemodialysis and Haemodiafiltration Calcium chloride dihydrate (0.343 g/L) + D-glucose monohydrate (1.47 g/L) + Magnesium chloride hexahydrate (0.136 g/L) + Potassium chloride (0.398 g/L) + Sodium bicarbonate (13.4 g/L) + Sodium chloride (7.52 g/L) Solution Extracorporeal XCORE SERVICES SDN BHD 2020-09-08 2021-12-12 Malaysia Accusol 35 Solution for Haemofiltration, Haemodialysis and Haemodiafiltration Calcium chloride dihydrate (0.343 g/L) + Magnesium chloride hexahydrate (0.136 g/L) + Sodium bicarbonate (13.4 g/L) + Sodium chloride (7.52 g/L) Solution Extracorporeal XCORE SERVICES SDN BHD 2020-09-08 2021-12-12 Malaysia - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image BALANCE %1,5 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L) Solution Intraperitoneal FRESENIUS MEDİKAL HİZMETLER A.Ş. 2013-01-29 Not applicable Turkey BALANCE %1,5 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2500 ML BIOFIN TORBA Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L) Solution Intraperitoneal FRESENIUS MEDİKAL HİZMETLER A.Ş. 2013-01-29 Not applicable Turkey BALANCE %1,5 GLIKOZ 1,75 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA Calcium chloride dihydrate (0.2573 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L) Solution Intraperitoneal FRESENIUS MEDİKAL HİZMETLER A.Ş. 2013-01-29 Not applicable Turkey BALANCE %1,5 GLIKOZ 1,75 MMOL / 1 KALSIYUM 2500 ML BIOFIN TORBA Calcium chloride dihydrate (0.2573 g/L) + D-glucose monohydrate (16.5 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L) Solution Intraperitoneal FRESENIUS MEDİKAL HİZMETLER A.Ş. 2013-01-29 Not applicable Turkey BALANCE %2,3 GLIKOZ 1,25 MMOL / 1 KALSIYUM 2000 ML BIOFIN TORBA Calcium chloride dihydrate (0.1838 g/L) + D-glucose monohydrate (25 g/L) + Sodium lactate (3.925 g/L) + Magnesium chloride hexahydrate (0.1017 g/L) + Sodium chloride (5.64 g/L) Solution Intraperitoneal FRESENIUS MEDİKAL HİZMETLER A.Ş. 2013-01-29 Not applicable Turkey
Categories
- ATC Codes
- A12AA07 — Calcium chlorideA11GB01 — Ascorbic acid (vit c) and calcium
- A11GB — Ascorbic acid (vitamin C), combinations
- A11G — ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
- A11 — VITAMINS
- A — ALIMENTARY TRACT AND METABOLISM
- Drug Categories
- Acidifying Agents
- Alimentary Tract and Metabolism
- Blood and Blood Forming Organs
- Blood Substitutes and Perfusion Solutions
- Calcium Compounds
- Calcium Salts
- Chlorides
- Chlorine Compounds
- Electrolyte Solutions
- Genito Urinary System and Sex Hormones
- Hemodialysis Solution
- I.V. Solution Additives
- Mineral Supplements
- Replacement Preparations
- Supplements
- Urologicals
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkaline earth metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a lanthanide.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkaline earth metal salts
- Sub Class
- Alkaline earth metal chlorides
- Direct Parent
- Alkaline earth metal chlorides
- Alternative Parents
- Inorganic chloride salts / Inorganic calcium salts
- Substituents
- Alkaline earth metal chloride / Inorganic calcium salt / Inorganic chloride salt / Inorganic salt
- Molecular Framework
- Not Available
- External Descriptors
- inorganic chloride, calcium salt (CHEBI:3312)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- OFM21057LP
- CAS number
- 10043-52-4
- InChI Key
- UXVMQQNJUSDDNG-UHFFFAOYSA-L
- InChI
- InChI=1S/Ca.2ClH/h;2*1H/q+2;;/p-2
- IUPAC Name
- calcium dichloride
- SMILES
- [Cl-].[Cl-].[Ca++]
References
- Synthesis Reference
Silvano Grosso, Kenneth E. Nelson, "Method for preparing liquid feed supplements containing calcium chloride." U.S. Patent US3962484, issued August, 1973.
US3962484- General References
- Not Available
- External Links
- KEGG Compound
- C08130
- PubChem Compound
- 5284359
- PubChem Substance
- 46507257
- ChemSpider
- 23237
- 1667640
- ChEBI
- 3312
- ChEMBL
- CHEMBL1200668
- PharmGKB
- PA448729
- RxList
- RxList Drug Page
- Wikipedia
- Calcium_chloride
- MSDS
- Download (74.1 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Not Available Acute Pancreatitis 1 somestatus stop reason just information to hide Not Available Completed Not Available Coronavirus Disease 2019 (COVID‑19) 1 somestatus stop reason just information to hide Not Available Completed Basic Science Heart Failure 1 somestatus stop reason just information to hide Not Available Completed Basic Science Perfusions 1 somestatus stop reason just information to hide Not Available Completed Prevention Arthroplasties, Replacement, Knee / Hemorrhage / Hip Arthroplasty 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- American Regent
- AstraZeneca Inc.
- Baxter International Inc.
- Cardinal Health
- General Injectables and Vaccines Inc.
- Hospira Inc.
- J T Baker
- Luitpold Pharmaceuticals Inc.
- Physicians Total Care Inc.
- Spectrum Pharmaceuticals
- Dosage Forms
Form Route Strength Solution Hemodialysis 0.257 g/1000ml Liquid Hemodialysis Solution Irrigation; Parenteral Powder, for solution Intraocular Solution Intraocular Solution Topical Solution Topical 360 - Solution Ophthalmic Concentrate; kit; solution Ophthalmic Kit; solution Intraocular Liquid Intravenous 100 mg / mL Injection, solution Parenteral 1000 MG Injection, solution Parenteral 500 MG Injection, solution Parenteral 500 MG/10ML Injection, solution Parenteral Injection, solution Parenteral 0.5 MEQ/ML Injection, solution Parenteral 1 G/10ML Injection, solution, concentrate Intravenous Injection, solution, concentrate Intravenous 1 G/10ML Solution, concentrate Parenteral Injection, solution, concentrate Intravenous; Parenteral Injection, solution, concentrate Intravenous; Parenteral 1 G/10ML Injection, solution, concentrate Intravenous; Parenteral 5 mEq/10ml Injection, solution, concentrate Intravenous; Parenteral 500 MG/10ML Injection Intravenous 100 mg/1mL Injection Intravenous; Intraventricular 100 mg/1mL Injection Parenteral 100 mg/1mL Injection, solution Intravenous 100 mg/1mL Injection, solution Intravenous 20 mg/1mL Injection, solution Intravenous; Intraventricular 100 mg/1mL Powder Hemodialysis 12.32 g / vial Powder Hemodialysis 3.78 g / vial Powder Hemodialysis 7.45 g / vial Solution Intravenous 100 mg / mL Powder, for solution Hemodialysis 12.9 g / pck Powder, for solution Hemodialysis 5.8 g / pck Powder Hemodialysis 6.1 g / pck Powder Hemodialysis 12.2 g / pck Powder, for solution Hemodialysis 7.45 g / bottle Powder, for solution Hemodialysis 14.9 g / bottle Solution Parenteral 100 mmol/l Injection, solution Intravenous 100 MMOL/L Solution Intraperitoneal 0.2573 g/l Solution Intraperitoneal 0.1838 g/L Solution Intra-arterial Solution Intravenous Injection, solution Parenteral Solution Intravenous 0.27 g/1000ml Solution Irrigation Solution Intraperitoneal Injection Intravenous Solution Intraperitoneal; Irrigation Injection, solution Intraperitoneal Solution Solution Intravenous 4.21 g/1000ml Solution Intrathecal Injection Intrathecal Emulsion Intravenous 0.468 g Solution Intraperitoneal 25.7 mg/100ml Solution, concentrate Hemodialysis Spray Oral Aerosol, spray Oral Solution Hemodialysis Solution Hemodialysis 7.77 g/l Solution Hemodialysis 8.46 g/l Solution Intravenous 600.0 mg Solution Hemodialysis 8.8 g/l Solution Hemodialysis 8.85 g/l Solution Hemodialysis 6.77 g/l Solution Hemodialysis; Intravenous Solution Oral Liquid Intraperitoneal Solution Hemodialysis; Intraperitoneal Liquid Intraocular Liquid Ophthalmic; Topical Emulsion Parenteral 20.000 g Injection Intravenous 1.6 g/l Injection Intravenous 20 mg/100ml Liquid Irrigation Solution, for slush Irrigation Solution Intravenous; Irrigation Injection Intravenous 0.027 % w/v Liquid Oral Liquid Buccal Spray Buccal Solution Intravenous 4.410 g Injection, solution Hemodialysis; Intravenous Kit; solution Intraocular; Irrigation Injection, emulsion Parenteral Emulsion Intravenous 0.466 g Injection, emulsion; injection, solution Intravenous Emulsion Parenteral Emulsion Intravenous Injection, solution Injection, emulsion Intravenous 4.656 g/1000ml Injection, emulsion Intravenous 6.792 g/1000ml Injection, solution, concentrate Intravenous Solution Intraperitoneal 0.184 g/l Injection, emulsion Intravenous Emulsion Intravenous 4 g Solution Intraocular; Ophthalmic Solution Extracorporeal; Intrabiliary; Intracardiac Rinse Dental Emulsion Intravenous 3 g Injection, solution Intravenous Injection, solution Intra-arterial Liquid Intravenous Kit Hemodialysis Solution Hemodialysis 0.257 g/l Kit; solution Topical Solution Intravenous 0.1 g/500ml Solution Irrigation; Topical Irrigant Irrigation Injection, solution Irrigation Solution Buccal; Oral; Topical Aerosol Oral Solution Intravenous 50.000 mL Powder, for solution Topical Emulsion Intravenous 13.000 g Solution Oral 11.700 mg Solution Parenteral 2.500 g Injection Parenteral Solution Intraocular; Irrigation Solution Oral 0.012 g Solution Extracorporeal Solution Parenteral Solution Intravenous 0.3675 g/1000ml Kit Topical Powder Topical Kit; solution Solution Topical 3000 KIU/ml Powder Soft tissue Liquid Ophthalmic - Prices
Unit description Cost Unit SureStep Test 25 Strip Box 31.92USD box Calcium chloride powder 0.44USD g Calcium chloride 10% vial 0.18USD ml Calcium chloride granules 0.1USD g Calcium chloride 10% ampul 0.07USD ml DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US6077836 No 2000-06-20 2017-06-20 US US6248726 No 2001-06-19 2018-06-19 US US7084130 No 2006-08-01 2021-11-29 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 782 °C Not Available water solubility 0.745 g/mL (at 20 °C) Not Available - Predicted Properties
Property Value Source Water Solubility 21.4 mg/mL ALOGPS logP 1.08 ALOGPS logP -0.57 Chemaxon logS -0.71 ALOGPS pKa (Strongest Acidic) 3.09 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9445 Blood Brain Barrier + 0.975 Caco-2 permeable + 0.6764 P-glycoprotein substrate Non-substrate 0.9039 P-glycoprotein inhibitor I Non-inhibitor 0.9891 P-glycoprotein inhibitor II Non-inhibitor 0.9866 Renal organic cation transporter Non-inhibitor 0.9196 CYP450 2C9 substrate Non-substrate 0.8116 CYP450 2D6 substrate Non-substrate 0.717 CYP450 3A4 substrate Non-substrate 0.7571 CYP450 1A2 substrate Non-inhibitor 0.7506 CYP450 2C9 inhibitor Non-inhibitor 0.8587 CYP450 2D6 inhibitor Non-inhibitor 0.9306 CYP450 2C19 inhibitor Non-inhibitor 0.8304 CYP450 3A4 inhibitor Non-inhibitor 0.956 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9002 Ames test Non AMES toxic 0.6808 Carcinogenicity Carcinogens 0.764 Biodegradation Ready biodegradable 0.6815 Rat acute toxicity 1.9786 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9433 hERG inhibition (predictor II) Non-inhibitor 0.9634
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 114.19825 predictedDeepCCS 1.0 (2019) [M+H]+ 116.09366 predictedDeepCCS 1.0 (2019) [M+Na]+ 124.36989 predictedDeepCCS 1.0 (2019)
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity)
- Specific Function
- calcium ion binding
- Gene Name
- S100A13
- Uniprot ID
- Q99584
- Uniprot Name
- Protein S100-A13
- Molecular Weight
- 11471.095 Da
References
- Sivaraja V, Kumar TK, Rajalingam D, Graziani I, Prudovsky I, Yu C: Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J. 2006 Sep 1;91(5):1832-43. Epub 2006 Jun 9. [Article]
Drug created at June 13, 2005 13:24 / Updated at October 10, 2024 16:41