Calcium chloride


Calcium chloride
Accession Number

Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers.

Small Molecule
Average: 110.984
Monoisotopic: 109.900296569
Chemical Formula
  • Calcio cloruro
  • Calcium chloride anhydrous
  • Calcium chloride, anhydrous
  • calcium(2+) chloride
External IDs
  • E-509
  • INS NO.509
  • INS-509


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For the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.

Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications & Blackbox Warnings
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Calcium is the fifth most abundant element in the body and the major fraction is in the bony structure. Calcium plays important physiological roles, many of which are poorly understood. It is essential for the functional integrity of the nervous and muscular systems. It is necessary for normal cardiac function and is one of the factors that operates in the mechanisms involved in the coagulation of blood.

Mechanism of action

Calcium chloride in water dissociates to provide calcium (Ca2+) and chloride (Cl-) ions. They are normal constituents of the body fluids and are dependent on various physiological mechanisms for maintenance of balance between intake and output. For hyperkalemia, the influx of calcium helps restore the normal gradient between threshold potential and resting membrane potential.

UProtein S100-A13Not AvailableHumans
Not Available
Volume of distribution
Not Available
Protein binding
Not Available

Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.

Route of elimination

Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.

Not Available
Not Available
Adverse Effects
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Too rapid injection may produce lowering of blood pressure and cardiac syncope. Persistent hypercalcemia from overdosage of calcium is unlikely because of rapid excretion.

Affected organisms
  • Humans and other mammals
Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
AbciximabThe therapeutic efficacy of Calcium chloride can be decreased when used in combination with Abciximab.
AcebutololThe therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium chloride.
AcenocoumarolThe therapeutic efficacy of Calcium chloride can be decreased when used in combination with Acenocoumarol.
AcetyldigitoxinCalcium chloride may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Acetylsalicylic acidThe therapeutic efficacy of Calcium chloride can be decreased when used in combination with Acetylsalicylic acid.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium chloride.
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium chloride is combined with Alfacalcidol.
Alpha-1-proteinase inhibitorAlpha-1-proteinase inhibitor may increase the thrombogenic activities of Calcium chloride.
AlteplaseThe therapeutic efficacy of Calcium chloride can be decreased when used in combination with Alteplase.
Aminocaproic acidThe risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Calcium chloride.
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Food Interactions
No interactions found.


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Product Ingredients
IngredientUNIICASInChI Key
Calcium chloride dihydrateM4I0D6VV5M10035-04-8LLSDKQJKOVVTOJ-UHFFFAOYSA-L
Calcium chloride hexahydrate1D898P42YW7774-34-7Not applicable
Active Moieties
Chloride ionionicQ32ZN4869816887-00-6VEXZGXHMUGYJMC-UHFFFAOYSA-M
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
International/Other Brands
Jarcal / LiquiCal-D 400
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Calciject Inj 100mg/mlLiquidIntravenousOmega Laboratories Ltd1990-12-31Not applicableCanada flag
Calcium ChlorideInjection100 mg/1mLIntravenous; IntraventricularMedical Purchasing Solutions, Llc1973-05-01Not applicableUS flag
Calcium ChlorideInjection, solution20 mg/1mLIntravenousCantrell Drug Company2011-03-08Not applicableUS flag
Calcium ChlorideInjection100 mg/1mLIntravenousAmneal-Agila, LLC2013-05-312017-12-31US flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenous; IntraventricularCardinal Health1984-09-172019-04-30US flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenousCardinal Health2011-06-142014-02-28US flag
Calcium ChlorideInjection100 mg/1mLParenteralAmphastar Pharmaceuticals, Inc.1990-01-022009-12-31US flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenousHospira, Inc.2005-09-14Not applicableUS flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenousAMERICAN REGENT, INC.2017-07-05Not applicableUS flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenous; IntraventricularGeneral Injectables & Vaccines, Inc.2010-03-01Not applicableUS flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Calcium ChlorideInjection100 mg/1mLIntravenous; IntraventricularInternational Medication Systems, Limited2018-07-08Not applicableUS flag
Calcium ChlorideInjection100 mg/1mLIntravenous; IntraventricularA-S Medication Solutions2018-07-082019-04-30US flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenousAMERICAN REGENT, INC.2018-02-06Not applicableUS flag
Calcium ChlorideInjection100 mg/1mLIntravenous; IntraventricularHF Acquisition Co LLC, DBA HealthFirst2019-12-09Not applicableUS flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenousMedefil, Inc.2019-08-22Not applicableUS flag
Calcium ChlorideInjection, solution100 mg/1mLIntravenousMedical Purchasing Solutions, Llc2019-08-22Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USPCalcium chloride (20 mg) + Sodium lactate (310 mg) + Potassium chloride (328 mg) + Sodium chloride (600 mg)SolutionIntravenousBaxter Laboratories2002-12-112016-07-15Canada flag
5% Dextrose In Lactated Ringer's InjectionCalcium chloride (20 mg) + Dextrose, unspecified form (5 g) + Sodium lactate (310 mg) + Potassium chloride (30 mg) + Sodium chloride (600 mg)SolutionIntravenousB. Braun Medical Inc.1993-12-312012-04-10Canada flag
Acetate Concentrate R07376Calcium chloride (6.432 g) + Dextrose, unspecified form (38.5 g) + Magnesium chloride (3.558 g) + Potassium chloride (2.609 g) + Sodium acetate (114.8 g) + Sodium chloride (204.5 g)LiquidHemodialysisBdh Inc.1995-12-312000-08-03Canada flag
Acid Concentrate (r04146)Calcium chloride (9.477 g) + Acetic acid (8.846 g) + Dextrose, unspecified form (60.8 g) + Magnesium chloride (3.744 g) + Sodium chloride (184 g)LiquidHemodialysisGenpharm Ulc1997-05-212004-07-30Canada flag
Acid Concentrate (r04938)Calcium chloride (9.476 g) + Acetic acid (8.846 g) + Dextrose, unspecified form (60.77 g) + Magnesium chloride (3.744 g) + Potassium chloride (5.491 g) + Sodium chloride (172.2 g)LiquidHemodialysisGenpharm Ulc1987-12-312001-08-03Canada flag
Acid Concentrate (r04968)Calcium chloride (3.384 g) + Acetic acid (8.846 g) + Magnesium chloride (3.744 g) + Potassium chloride (5.491 g) + Sodium chloride (180.8 g)LiquidHemodialysisGenpharm Ulc1988-12-312004-07-30Canada flag
Acid Concentrate (r04969)Calcium chloride (3.384 g) + Acetic acid (8.846 g) + Magnesium chloride (3.744 g) + Potassium chloride (2.746 g) + Sodium chloride (180.8 g)LiquidHemodialysisGenpharm Ulc1988-12-312004-07-30Canada flag
Acid Concentrate (r04974)Calcium chloride (6.769 g) + Acetic acid (8.846 g) + Magnesium chloride (3.744 g) + Potassium chloride (8.237 g) + Sodium chloride (172.2 g)LiquidHemodialysisGenpharm Ulc1988-12-312004-07-30Canada flag
Acid Concentrate (r04975)Calcium chloride (6.769 g) + Acetic acid (8.846 g) + Magnesium chloride (3.744 g) + Potassium chloride (2.746 g) + Sodium chloride (172.2 g)LiquidHemodialysisGenpharm Ulc1988-12-312004-07-30Canada flag
Acid Concentrate (r04976)Calcium chloride (6.769 g) + Acetic acid (8.846 g) + Magnesium chloride (3.744 g) + Potassium chloride (5.491 g) + Sodium chloride (172.2 g)LiquidHemodialysisGenpharm Ulc1988-12-312004-07-30Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularGeneral Injectables & Vaccines, Inc.2010-03-01Not applicableUS flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularHF Acquisition Co LLC, DBA HealthFirst2018-09-13Not applicableUS flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenousGeneral Injectables & Vaccines2010-03-012014-02-01US flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)InjectionParenteralAmphastar Pharmaceuticals, Inc.1973-05-012009-12-31US flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularHospira, Inc.2006-01-24Not applicableUS flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularCardinal Health1984-09-172019-04-30US flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)InjectionIntravenous; IntraventricularMedical Purchasing Solutions, Llc1973-05-01Not applicableUS flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)InjectionParenteralAmphastar Pharmaceuticals, Inc.2000-06-012013-01-25US flag
Calcium ChlorideCalcium chloride dihydrate (20 mg/1mL)Injection, solutionIntravenousCantrell Drug Company2011-03-08Not applicableUS flag
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenousCardinal Health2011-06-142014-02-28US flag


ATC Codes
A12AA07 — Calcium chlorideA11GB01 — Ascorbic acid (vit c) and calciumG04BA03 — Calcium chlorideB05XA07 — Calcium chloride
Drug Categories
Chemical TaxonomyProvided by Classyfire
This compound belongs to the class of inorganic compounds known as alkaline earth metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a lanthanide.
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Alkaline earth metal salts
Sub Class
Alkaline earth metal chlorides
Direct Parent
Alkaline earth metal chlorides
Alternative Parents
Inorganic chloride salts / Inorganic calcium salts
Alkaline earth metal chloride / Inorganic calcium salt / Inorganic chloride salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
inorganic chloride, calcium salt (CHEBI:3312)

Chemical Identifiers

CAS number
InChI Key
calcium dichloride


Synthesis Reference

Silvano Grosso, Kenneth E. Nelson, "Method for preparing liquid feed supplements containing calcium chloride." U.S. Patent US3962484, issued August, 1973.

General References
Not Available
KEGG Compound
PubChem Compound
PubChem Substance
RxList Drug Page
AHFS Codes
  • 40:34.00* — Hemodialysis Solution
  • 40:12.00 — Replacement Preparations
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Clinical Trials

Clinical Trials
4CompletedTreatmentAPD / Continuous ambulatory peritoneal dialysis therapy / Diabetes / ESRD1
4CompletedTreatmentCesarean Section / Hypotension / Pregnant State / Spinal Anaesthesia1
4CompletedTreatmentChronic Kidney Disease (CKD) / Peritoneal dialysis therapy1
4CompletedTreatmentChronic Renal Failure (CRF)1
4CompletedTreatmentChronic Renal Failure (CRF) / Peritoneal Membrane Disorder1
4CompletedTreatmentCoronary Artery Bypass Grafting (CABG) / Valve Surgery1
4CompletedTreatmentCoronary Artery Disease (CAD) / Valvular Heart Disease1
4CompletedTreatmentFluid Overload / Postoperative Complications1
4CompletedTreatmentGoal Directed Fluid Therapy1


Not Available
  • American Regent
  • AstraZeneca Inc.
  • Baxter International Inc.
  • Cardinal Health
  • General Injectables and Vaccines Inc.
  • Hospira Inc.
  • J T Baker
  • Luitpold Pharmaceuticals Inc.
  • Physicians Total Care Inc.
  • Spectrum Pharmaceuticals
Dosage Forms
SolutionHemodialysis6.12 g/L
SolutionHemodialysis0.257 g/1000ml
SolutionHemodialysis2.94 g/1000ml
SolutionHemodialysis7.52 g/L
SolutionExtracorporeal7.52 g/L
Injection, solutionIntravenous2.5 g/1000ml
Injection, solutionIntravenous2.5 g/500mL
SolutionIntravenous2.55 g/L
SolutionIntravenous0.61 g/L
SolutionIntravenous1.79 g/L
SolutionIrrigation; Parenteral0.39 %
Powder, for solutionIntraocular
SolutionTopical2 IU/ml
SolutionTopical91 mg/ml
SolutionTopical91 mg
SolutionIntraperitoneal951 mg/L
Injection, solutionIntravenous6 g/L
SolutionIntravenous0.4 g/1000ml
InjectionIntravenous0.03 g/100ml
SolutionIntraperitoneal0.1838 g/L
SolutionIntraperitoneal0.2573 g/L
SolutionIntraperitoneal0.2033 g/l
SolutionIntraocular; Irrigation1950 mg
SolutionIntraperitoneal1.5 g/100ml
SolutionIntraperitoneal2.5 g/100ml
SolutionIntraperitoneal4.25 g/100ml
Injection, solutionIntraperitoneal538 mg/100mL
Solution90 mg/ml
Injection, solutionIntraperitoneal0.3675 g/L
Injection, solutionIntraperitoneal0.5145 g/L
SolutionIntraperitoneal16.5 g/L
Injection, solutionIntraperitoneal30 g
SolutionIntraperitoneal5.786 g/L
Injection, solutionIntraperitoneal50 g
Injection, solutionIntraperitoneal85 g
SolutionIntravenous5 %
SolutionIntravenous0.64 g/100ml
SolutionIntravenous0.86 g/100ml
SolutionIntravenous3.1 g/L
Injection, solutionIntravenous3.1 g/L
Kit; solutionIntraocular
Injection, solutionParenteral1000 MG
Injection, solutionParenteral500 MG
Injection, solutionParenteral1 G/10ML
Injection, solutionParenteral500 MG/10ML
Injection, solutionParenteral0.5 MEQ/ML
Injection, solution, concentrateIntravenous1 G/10ML
Injection, solution, concentrateIntravenous500 MG/10ML
Solution, concentrateParenteral1 G/10ML
Injection, solution, concentrateIntravenous; Parenteral1 G/10ML
Injection, solution, concentrateIntravenous; Parenteral5 mEq/10ml
Injection, solution, concentrateIntravenous; Parenteral500 MG/10ML
Injection, solution, concentrateIntravenous290 mg/10ml
InjectionIntravenous100 mg/1mL
InjectionIntravenous; Intraventricular100 mg/1mL
InjectionParenteral100 mg/1mL
Injection, solutionIntravenous100 mg/1mL
Injection, solutionIntravenous20 mg/1mL
Injection, solutionIntravenous; Intraventricular100 mg/1mL
Powder, for solutionHemodialysis
SolutionParenteral100 mmol/l
Injection, solution100 MMOL/L
Injection, solutionIntraperitoneal0.1838 g/L
SolutionIntraperitoneal1.5 %
Injection, solutionIntraperitoneal5.786 g/L
Solution0.1838 g/L
SolutionIntraperitoneal46.75 g/L
SolutionHemodialysis0.1838 g/L
Solution0.2573 g/L
SolutionIntraperitoneal4.25 %
SolutionIntraperitoneal0.0003 g
Injection, solutionIntravenous5.786 g/L
Solution6340 mg/L
Injection, solutionIntravenous4.02 g/l
Injection, solutionIntravenous5.11 g/l
Injection, solutionIntravenous6.21 g/l
Injection, solutionIntravenous7.3 g/l
Injection, solutionParenteral3 %
Injection, solutionParenteral5 %
SolutionIntravenous0.27 g/L
SolutionExtracorporeal0.8766 g/L
Solution, concentrateHemodialysis2.067 g
SolutionExtracorporeal0.0022 g/L
SolutionIntravenous6.4 g/L
SolutionIntraperitoneal5.08 mg/100ml
SolutionIntraperitoneal; Irrigation0.1837 mg
SolutionIntraperitoneal18.3 mg
Injection, solutionIntraperitoneal
SolutionIntraperitoneal1.36 %
SolutionIntraperitoneal2.27 %
SolutionIntraperitoneal3.86 %
Solution22.7 g/L
Solution13.6 g/L
SolutionIntraperitoneal22.7 g/L
Solution38.6 g/L
SolutionIntraperitoneal13.6 g/L
SolutionIntraperitoneal38.6 g/L
Injection, solutionIntravenous4.9 g/1000ml
Injection, solutionIntravenous7.35 g/1500ml
Injection, solutionIntravenous9.8 g/2000ml
SolutionIntravenous4.21 g/1000ml
SolutionHemodialysis1.98 g/1000ml
SolutionHemodialysis0.91 g/1000ml
SolutionIntravenous1.098 g/L
SolutionHemodialysis10.39 g/L
Injection, solutionIntravenous10.39 g/L
Injection, solutionIntravenous5 g/L
SolutionIntravenous6.124 g
SolutionIntravenous0.61 g
SolutionIntravenous0.298 mg/ml
SolutionParenteral0.186 g
SolutionIntravenous1.66 g/L
SolutionIntraperitoneal0.0257 g
SolutionIntraperitoneal75 g/L
Injection, solutionIntraperitoneal257 mg/L
SolutionIntraperitoneal0.051 g/l
SolutionIntraperitoneal7.5 g/100mL
Injection, emulsionIntravenous11.41 g/1085ml
Injection, emulsionIntravenous11.41 g/1435ml
Injection, emulsionIntravenous13.17 g/2020ml
Injection, emulsionIntravenous7.08 g/1085ml
Injection, emulsionIntravenous9.46 g/1450ml
EmulsionParenteral3.99 g/1085ml
EmulsionParenteral2.05 g/1085ml
Solution, concentrateHemodialysis0.864 mg
SolutionIntravenous0.15 g/L
SolutionIntravenous0.2 g
SolutionIntravenous1.63 g
Aerosol, sprayOral0.0026 g/50ml
SolutionHemodialysis2.4 g/1000ml
SolutionIntravenous2.57 g/L
LiquidHemodialysis9.74 g/L
SolutionHemodialysis; Intravenous2.033 g/L
SolutionOral30 mg
SolutionOral29.1 mg
SolutionOral0.275 g
SolutionOral275 mg
SolutionIntravenous3 g
SolutionIntravenous0.31 %
SolutionIntraperitoneal7.5 %
SolutionHemodialysis; Intraperitoneal
SolutionIntravenous0.02 g
Solution0.64 g/100ml
Injection, solutionIntravenous50 g
SolutionIntravenous0.64 %
SolutionIntravenous0.07 g
Injection, emulsionIntravenous
Injection, emulsionIntravenous40 g/1026ml
Injection, emulsionIntravenous467 mg/100mL
Injection, emulsionIntravenous60 g/1540ml
InjectionIntravenous110 g
InjectionIntravenous165 g
InjectionIntravenous220 g
InjectionIntravenous275 g
InjectionIntravenous107 g
InjectionIntravenous143 g
InjectionIntravenous178 g
SolutionIntravenous8.6 %
PowderTopical120 mg/vial
PowderTopical240 mg/vial
PowderTopical480 mg/vial
SolutionIntravenous20.475 %
Injection, emulsionIntravenous10.5 g
Injection, emulsionIntravenous14 g
Injection, emulsionIntravenous2.1 g
Injection, emulsionIntravenous3.1 g
Injection, emulsionIntravenous4.2 g
Injection, emulsionIntravenous7 g
SolutionIntravenous20 mg/100ml
Solution, for slushIrrigation
SolutionIntravenous20 mg
SolutionIntravenous; Irrigation0.2 mg
Injection, solutionIntravenous50 mg/mL
Injection, solutionIntravenous3 g/L
Injection, solutionIntravenous3.14 g/L
Injection, emulsionIntravenous1.17 g
Injection, emulsionIntravenous1.56 g
Injection, emulsionIntravenous1.755 g
Injection, emulsionIntravenous2.34 g
Injection, emulsionIntravenous3.12 g
Injection, emulsionIntravenous3.51 g
Injection, emulsionIntravenous4.68 g
SolutionHemodialysis0.2205 g/1000ml
Injection, solutionHemodialysis; Intravenous6.136 g/1000ml
SolutionHemodialysis; Intravenous0.1017 g/L
SolutionHemodialysis0.2205 g/L
Kit; solutionIntraocular; Irrigation
SolutionIntravenous5 g/100ml
SolutionIntravenous0.86 %
SolutionIntravenous16 g/L
Injection, emulsionParenteral2.33 g
Injection, emulsionIntravenous1.03 g
Injection, emulsionIntravenous1.83 g
EmulsionIntravenous1.83 g
InjectionIntravenous1.03 g
Injection, emulsionIntravenous1.6 g/100mL
Injection, emulsion; injection, solutionIntravenous3.2 g/100mL
EmulsionIntravenous20 mg
EmulsionIntravenous16 g
Injection, emulsionIntravenous3.88 g/1000ml
EmulsionParenteral20 g/l
EmulsionParenteral3.88 g
EmulsionIntravenous88 g
Injection, emulsionIntravenous120 g
Injection, emulsionIntravenous160 g
Injection, emulsionIntravenous4.66 g/1000ml
EmulsionParenteral1.872 g/l
EmulsionParenteral0.222 g
Injection, emulsionIntravenous150 g
Injection, emulsionIntravenous225 g
Injection, emulsionIntravenous300 g
Injection, emulsionIntravenous4.25 g/625ml
EmulsionParenteral6.792 g/l
EmulsionIntravenous6.792 mg
EmulsionIntravenous150 g
EmulsionIntravenous225 g
EmulsionParenteral2.4 g/l
EmulsionParenteral2.88 g/l
EmulsionIntravenous4.656 g
EmulsionParenteral6.792 g
EmulsionIntravenous6.792 g
Injection, solutionIntravenous4.85 g/1000ml
SolutionParenteral0.5 g
Injection, solutionIntravenous5.82 g/1000ml
Injection, solutionIntravenous11.64 g/2000ml
SolutionParenteral1.56 g
Injection, solution0.6 g/L
SolutionParenteral4.54 g
Injection, solution, concentrateIntravenous
Injection, solutionIntraperitoneal95.1 mg/100mL
Injection, solutionIntraperitoneal951 mg/L
SolutionParenteral95.1 mg
SolutionIntraperitoneal510 mg/l
Injection, emulsionIntravenous120 g/1875ml
Injection, emulsionIntravenous160 g/2500ml
Injection, emulsionIntravenous80 g/1250ml
Injection, emulsionIntravenous150 g/1250ml
Injection, emulsionIntravenous225 g/1875ml
Injection, emulsionIntravenous300 g/2500ml
Injection, emulsionIntravenous180 g/1250ml
Injection, emulsionIntravenous270 g/1875ml
Injection, emulsionIntravenous360 g/2500ml
Injection, emulsionIntravenous11.64 g/2500ml
Injection, emulsionIntravenous5.82 g/1250ml
Injection, emulsionIntravenous8.73 g/1875ml
Injection, emulsionIntravenous90 g/625ml
Injection, emulsionIntravenous12 g/1500ml
Injection, emulsionIntravenous32 g/1000ml
Injection, emulsionIntravenous0.52 g/1000ml
Injection, emulsionIntravenous0.42 g/1000ml
Injection, emulsionIntravenous1.6 g
InjectionIntravenous2.27 g/l
InjectionIntravenous4.12 g/l
SolutionIntravenous7.14 g
SolutionIntravenous9.52 g
SolutionIntravenous11.9 g
EmulsionIntravenous6.41 g
EmulsionIntravenous9.61 g
EmulsionIntravenous12.82 g
Injection, emulsionIntravenous6.41 g/1000ml
EmulsionIntravenous4 g
Injection, emulsionIntravenous8.24 g/1000ml
SolutionIntraocular; Ophthalmic7.8 mg
SolutionExtracorporeal; Intrabiliary; Intracardiac0.671 g/L
SolutionOral29.4 mg
SolutionOral100 mg
EmulsionParenteral1.26 g
EmulsionIntravenous3 g
Injection, emulsionIntravenous3.66 g
Injection, emulsionIntravenous5.5 g
Injection, emulsionIntravenous7.33 g
Injection, emulsionIntravenous9.16 g
Injection, emulsionIntravenous3.66 g/1000ml
SolutionIntraperitoneal5.8443 g
Injection, solutionIntraperitoneal18.3 mg/100mL
Injection, solutionIntravenous5 %
Injection, solutionIntravenous3.68 g/1L
SolutionHemodialysis0.225 g/1000ml
SolutionHemodialysis3.68 g/L
SolutionIntraperitoneal13.6 g/1000ml
SolutionIntraperitoneal22.7 g/1000ml
SolutionIntraperitoneal38.6 g/1000ml
SolutionIntraperitoneal15 g/L
SolutionIntraperitoneal25 g/L
SolutionIntravenous25 g/L
SolutionIntraperitoneal42.5 g/L
SolutionIntraperitoneal2.1 g/1000ml
Injection, solutionIntravenous
Injection, solutionIntra-arterial
SolutionIntravenous0.035 %
SolutionIntravenous3.2 g/100mL
SolutionIntravenous1.6 g/100mL
SolutionHemodialysis; Intravenous
SolutionIntravenous2.033 g/L
SolutionHemodialysis0.257 g/L
SolutionHemodialysis0.258 g/L
Injection, solutionIntravenous0.86 g/100mL
Kit; solutionTopical
SolutionIntravenous6 g/l
SolutionParenteral8.6 g/l
Injection, solutionIntravenous6 g/1000ml
SolutionIntravenous0.6 g/100ml
Injection, solutionIntravenous8.6 g/L
SolutionIntravenous0.1 g/500ml
Injection, solutionIntravenous2.6 g/1000ml
Injection, solutionIntravenous3.23 g/L
SolutionIntravenous0.31 g/100ml
SolutionIrrigation; Topical20 mg
SolutionIntravenous0.4 g/l
Injection, solutionIntravenous0.27 g/l
SolutionParenteral9 g/l
Injection, solutionIntravenous0.3 g/l
SolutionParenteral0.33 g/l
SolutionBuccal; Oral; Topical16.2 mg
SprayOral5 mg
Powder, for solutionTopical120 MG
Powder, for solutionTopical240 MG
Powder, for solutionTopical480 MG
EmulsionParenteral1.6 g/l
EmulsionParenteral0.61 g/l
EmulsionParenteral440 mg
Injection, emulsionIntravenous4.4 g/1000ml
EmulsionParenteral3.1 g
Injection, emulsionIntravenous7.1 g/1000ml
EmulsionParenteral50 g
Solution0.184 g/L
Injection, solutionIntraperitoneal0.184 g/L
SolutionIntravenous0.2 mg
SolutionIntravenous0.165 g
SolutionParenteral25.7 mg
SolutionIntraperitoneal25.7 mg
SolutionIntravenous6 mg
SolutionParenteral0.033 g
InjectionParenteral0.033 g
SolutionIntravenous33 mg
SolutionExtracorporeal3.22 g/L
SolutionExtracorporeal6.43 g/L
SolutionExtracorporeal3.22 g/480ml
Injection, solutionIntraperitoneal5.38 g/l
Injection, solutionIntraperitoneal5.67 g/l
SolutionIntraperitoneal22.73 g/L
SolutionIntraocular; Irrigation0.39 g
Injection, solutionIntravenous5.64 g/L
SolutionIntravenous50 g
SolutionIntravenous5.552 g
SolutionIntravenous0.3 g
SolutionIntravenous0.67 g
SolutionIntravenous0.37 g/L
EmulsionParenteral0.28 g
EmulsionParenteral0.18 g
SolutionIntravenous0.6 g/L
PowderTopical91 mg/ml
SolutionTopical3000 kiu
SolutionTopical45.5 mg/ml
Kit; solution91 mg/mL
PowderSoft tissue91 mg/ml
SolutionTopical40 μmol/ml
SolutionIntravenous; Irrigation0.62 g/100ml
EmulsionParenteral4.34 g
EmulsionParenteral3.95 g
EmulsionParenteral28 g/1000ml
Unit descriptionCostUnit
SureStep Test 25 Strip Box31.92USD box
Calcium chloride powder0.44USD g
Calcium chloride 10% vial0.18USD ml
Calcium chloride granules0.1USD g
Calcium chloride 10% ampul0.07USD ml
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Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US6077836No2000-06-202017-06-20US flag
US6248726No2001-06-192018-06-19US flag
US7084130No2006-08-012021-11-29US flag


Experimental Properties
melting point (°C)782 °CNot Available
water solubility0.745 g/mL (at 20 °C)Not Available
Predicted Properties
Water Solubility21.4 mg/mLALOGPS
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Human Intestinal Absorption+0.9445
Blood Brain Barrier+0.975
Caco-2 permeable+0.6764
P-glycoprotein substrateNon-substrate0.9039
P-glycoprotein inhibitor INon-inhibitor0.9891
P-glycoprotein inhibitor IINon-inhibitor0.9866
Renal organic cation transporterNon-inhibitor0.9196
CYP450 2C9 substrateNon-substrate0.8116
CYP450 2D6 substrateNon-substrate0.717
CYP450 3A4 substrateNon-substrate0.7571
CYP450 1A2 substrateNon-inhibitor0.7506
CYP450 2C9 inhibitorNon-inhibitor0.8587
CYP450 2D6 inhibitorNon-inhibitor0.9306
CYP450 2C19 inhibitorNon-inhibitor0.8304
CYP450 3A4 inhibitorNon-inhibitor0.956
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9002
Ames testNon AMES toxic0.6808
CarcinogenicityCarcinogens 0.764
BiodegradationReady biodegradable0.6815
Rat acute toxicity1.9786 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9433
hERG inhibition (predictor II)Non-inhibitor0.9634
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)


Mass Spec (NIST)
Not Available
Not Available


Pharmacological action
General Function
Zinc ion binding
Specific Function
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion doe...
Gene Name
Uniprot ID
Uniprot Name
Protein S100-A13
Molecular Weight
11471.095 Da
  1. Sivaraja V, Kumar TK, Rajalingam D, Graziani I, Prudovsky I, Yu C: Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J. 2006 Sep 1;91(5):1832-43. Epub 2006 Jun 9. [PubMed:16766622]

Drug created on June 13, 2005 13:24 / Updated on February 24, 2021 19:34