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Displaying drugs 601 - 625 of 14438 in total

Testosterone enantate benzilic acid hydrazone

Approved
Experimental
Matched Categories: … Testosterone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Eptifibatide

Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics.
Approved
Investigational
Matched Description: … Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Dienestrol

Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of...
Approved
Investigational
Matched Description: … Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and ... Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness ... include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Ustekinumab

Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic disease-modifying anti-rheumatic drug (bDMARDs) that...
Approved
Investigational
Matched Description: … and subcutaneous formulations of the drug based on the dosing schedule and condition being treated. ... the interleukin (IL)-12 and IL-23 cytokines. ... IL-23, which are cytokines that are involved in immune and inflammatory responses. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …

Bleomycin

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Approved
Investigational
Matched Description: … It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. ... of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Lumasiran

Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). This condition, caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of oxalate, causing calcium crystal formation. These patients experience frequent kidney stones, nephrocalcinosis, and renal failure. Oxlumo, producted by...
Approved
Investigational
Matched Description: … [L23554] These patients experience frequent kidney stones, nephrocalcinosis, and renal failure. ... consisted of symptomatic treatment such as hyperhydration, inhibitors of crystallization, [pyridoxine], and …
Matched Salts name: … Lumasiran sodium …
Matched Categories: … Alimentary Tract and Metabolism ... Nucleic Acids, Nucleotides, and Nucleosides ... Various Alimentary Tract and Metabolism Products …

Nadroparin

Nadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa. Nadroparin halts the coagulation pathway by inhibiting the activation of thrombin (factor IIa) by factor Xa. The amplification of the fibrin clotting cascade is stopped once...
Approved
Investigational
Matched Description: … It is derived from porcine sources and has a mean molecular size of 5000 daltons. ... heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and ... The amplification of the fibrin clotting cascade is stopped once factors Xa and IIa are inactivated. …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …

Glucarpidase

Glucarpidase is a recombinant carboxypeptidase G2 produced by genetically modified Escherichia coli bacteria. It is a 390-amino acid homodimer protein. High-dose methotrexate, an antifolate agent, has been widely and safely used for many decades in treating various cancers; however, even with aggressive hydration, urine alkalinization, and leucovorin rescue, some patients...
Approved
Investigational
Matched Description: … [L39855] High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades ... This can lead to delayed renal clearance of methotrexate and elevated drug plasma levels, increasing ... in treating various cancers; however, even with aggressive hydration, urine alkalinization, and leucovorin …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …

Tagraxofusp

Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in Escherichia coli.[A253762, A253887, L43702] Tagraxofusp received its first global approval by the FDA on December 21, 2018...
Approved
Investigational
Matched Description: … fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Dalteparin

Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the range of 2000-9000....
Approved
Matched Description: … composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and ... LMWHs have a more predictable response, a greater bioavailability, and a longer anti-Xa half life than …
Matched Salts name: … Dalteparin sodium …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …

Hyaluronidase (ovine)

Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.
Approved
Investigational
Matched Categories: … Enzymes and Coenzymes …

Pancrelipase protease

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase protease is a mix of enzymes, formed by trypsin and chymotrypsin, that proteolytically cleave peptide bonds and are involved in food digestion.[A32742, L2543]...
Approved
Matched Description: … cleave peptide bonds and are involved in food digestion. ... Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and ... mixture, including pancrelipase protease, was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and …
Matched Categories: … Enzymes and Coenzymes …

Sinapultide

Sinapultide (also known as KL4 peptide) is a synthetic protein used to mimic human lung surfactant protein B. This protein has a weight of 2469.40. Sinapultide is a 21-residue peptide made up of lysine (K) and leucine (L) residues with the sequence KLLLLKLLLLKLLLLKLLLLK (KL4), in aqueous dispersion with the phospholipids...
Approved
Matched Description: … Surfactant replacement therapy has been commonly used to prevent and treat RDS in these newborns and ... [L2502] Sinapultide is a 21-residue peptide made up of lysine (K) and leucine (L) residues with the ... [L2505] Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in preterm …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Sulfamethizole

A sulfathiazole antibacterial agent.
Approved
Investigational
Vet approved
Matched Categories: … Blood and Blood Forming Organs ... Sulfonamides and trimethoprim ... Genito Urinary System and Sex Hormones ... Blood Substitutes and Perfusion Solutions ... Gynecological Antiinfectives and Antiseptics …

Insulin glargine

Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … and proteolysis. ... tissues such as the liver, fat cells, and skeletal muscle. ... addition of two arginines to the C-terminus (positions B31 and 32) of the B-chain. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... insulin glargine and lixisenatide ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Buserelin

Buserelin is a synthetic peptide analog of the luteinizing hormone-releasing hormone (LHRH) agonist, which stimulates the pituitary gland's gonadotrophin-releasing hormone receptor (GnRHR). It is used in prostate cancer treatment.
Approved
Investigational
Matched Categories: … Hormones and Related Agents ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Pentagastrin

A synthetic pentapeptide that mimics the actions of endogenous gastrin when given parenterally. It works by stimulating the secretion of gastric acid, pepsin, and intrinsic factor. It has also been used as a diagnostic aid.
Approved
Matched Description: … It works by stimulating the secretion of gastric acid, pepsin, and intrinsic factor. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Vidarabine

A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus.
Approved
Investigational
Matched Description: … viruses, the vaccinia VIRUS and varicella zoster virus. ... It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures ... and significant antiviral activity against infections caused by a variety of viruses such as the herpes …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Cefpiramide

Cefpiramide is a third-generation cephalosporin antibiotic.
Approved
Matched Salts name: … Cefpiramide sodium …

Tiludronic acid

Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to etidronic acid and clodronic acid.[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone....
Approved
Investigational
Vet approved
Matched Description: … thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and ... A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and …
Matched Categories: … Drugs Affecting Bone Structure and Mineralization …

Carbocisteine

Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD) and other respiratory conditions characterized by increased mucus production. Individuals with COPD have a greater risk of pulmonary infection due to the growth and accumulation of viruses and bacteria in thick bronchial mucus. Carbocisteine is a mucolytic drug...
Approved
Investigational
Matched Description: … Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD)[A231169] and other ... by physicians in France and Italy. ... viruses and bacteria in thick bronchial mucus. …
Matched Categories: … Cough and Cold Preparations ... Amino Acids, Peptides, and Proteins …

Roxadustat

Roxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels. Roxadustat was first approved...
Approved
Investigational
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Ximelagatran

Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former. In 2006, its manufacturer AstraZeneca announced that it would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and to discontinue...
Approved
Investigational
Withdrawn
Matched Description: … intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and ... would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and …
Matched Categories: … Blood and Blood Forming Organs …

Agomelatine

Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. The Committee...
Approved
Investigational
Matched Description: … Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors ... Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines …

Isavuconazonium

Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it...
Approved
Investigational
Matched Description: … [A38834] It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and ... Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July ... 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed …
Matched Categories: … Isavuconazole and Prodrugs …
Displaying drugs 601 - 625 of 14438 in total