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Displaying drugs 2351 - 2375 of 14951 in total
Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's. Zotepine was never approved by the FDA. In 1993,...
Approved
Investigational
Withdrawn
Matched Description: … [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany ... It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd. ... In 1993, it was classified as inactive drug substance (Status I, Type II) and in 1995 the FDA studied …
Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of clinical trial NCT04756531. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication.[A234224,A234229,A234234]...
Approved
Investigational
Matched Description: … [L33354] 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. ... in Canada in January 2022 for the treatment of adult patients with mild-moderate COVID-19 [L39544] and ... granted an emergency use authorization to Paxlovid, a co-packaged product containing both nirmatrelvir and
Matched Categories: … nirmatrelvir and ritonavir ... Amino Acids, Peptides, and Proteins …
Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension. Omidenepag isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and agonistic activity towards the prostaglandin E2 (EP2) receptor.[A253263,A253268] Prostanoid FP receptor agonists (FP...
Approved
Investigational
Matched Description: … topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ... isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and ... [A253253] In 2018, omidenepag isopropyl was approved in Japan for the treatment of glaucoma and ocular …
Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism. TAS-102 is indicated for the treatment of metastatic colorectal cancer which has been...
Approved
Investigational
Matched Description: … metastatic colorectal cancer which has been previously treated with fluoropyrimidine-, oxaliplatin- and
Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019.
Approved
Investigational
Matched Description: … -2 and high risk primary and secondary myelofibrosis. ... Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Sulfur hexafluoride is an ultrasound contrast agent indicated for use •in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms •in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric...
Approved
Matched Description: … ultrasound contrast agent indicated for use •in echocardiography to opacify the left ventricular chamber and ... echocardiograms •in ultrasonography of the liver for characterization of focal liver lesions in adult and
Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular...
Approved
Investigational
Matched Description: … differentiation, and in pathogenic angiogenesis, lymphogenesis, tumour growth and cancer progression ... 4; the platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. ... kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Approved
Experimental
Matched Iupac: … iron(3+) 2-hydroxypropane-1,2,3-tricarboxylic acid amine …
Atopic dermatitis (AD) is an inflammatory skin disorder that causes skin inflammation, skin barrier dysfunction, and chronic pruritus. It is estimated to affect up to 20% of adults and children worldwide, and is frequently associated with other atopic conditions such as asthma or allergic rhinitis. While AD is a heterogenous...
Approved
Investigational
Matched Description: … [A242432] It is estimated to affect up to 20% of adults and children worldwide, and is frequently associated ... was subsequently approved in Canada in October 2021 and the US in December 2021. ... dermatitis (AD) is an inflammatory skin disorder that causes skin inflammation, skin barrier dysfunction, and
Matched Categories: … Amino Acids, Peptides, and Proteins …
Prostate cancer is the most common non-cutaneous malignancy affecting men in North America - despite this, an ongoing challenge in prostate cancer therapy is the difficulty in imaging the extent and location of tumor metastases and recurrences. The images generated by positron emission tomography (PET) are less detailed than those...
Approved
Investigational
Matched Iupac: … 2S)-2-({[(1S)-1-carboxy-5-{[6-(¹⁸F)fluoropyridin-3-yl]formamido}pentyl]carbamoyl}amino)pentanedioic acid
Matched Description: … location of tumor metastases and recurrences. ... and more accurate detection of suspected prostate cancer metastases or recurrences. ... despite this, an ongoing challenge in prostate cancer therapy is the difficulty in imaging the extent and
Matched Categories: … Amino Acids, Peptides, and Proteins …
Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
Approved
Investigational
Matched Description: … Dezocine is a partial opiate drug and is used for pain management. …
Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences , [FDA label]. It was originally...
Approved
Matched Description: … sequences and human constant region sequences [A40017], [FDA label]. ... The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region ... chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and
Matched Categories: … Amino Acids, Peptides, and Proteins ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Canagliflozin, also known as Invokana, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018...
Approved
Matched Description: … It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 ... inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and
Matched Categories: … Alimentary Tract and Metabolism ... metformin and canagliflozin …
Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels. It represents a significant addition to antibacterial treatment option as...
Approved
Investigational
Matched Description: … Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam ... Cefiderocol was granted designation as a Qualified Infectious Disease Product and granted priority review ... effective *in vitro* against multidrug resistant strains including extended spectrum β-lactamase producers and
Metamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids. It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability. Metamizole was formerly marketed in the US as Dimethone tablets and injection, Protemp oral liquid, and other drug products, and was withdrawn due to...
Approved
Investigational
Withdrawn
Matched Iupac: … [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonic acid
Matched Description: … , Norway and Australia. ... liquid, and other drug products, and was withdrawn due to its association with potentially fatal agranulocytosis ... It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability. …
Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major depression. Amisulpride predominantly works in...
Approved
Investigational
Matched Description: … D2 and D3 receptors. ... , and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major ... Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine …
Matched Categories: … Benzamides and benzamide derivatives …
Flotufolastat F-18 (18F-rhPSMA-7.3) is an 18F-labeled ligand that targets the prostate-specific membrane antigen (PSMA).[A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of 18F-labeled ligands for positron emission tomography (PET) offers accurate diagnostic imaging. Unlike 68Ga-labeled PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer...
Approved
Investigational
Matched Iupac: … formamido)propanamido]pentyl]carbamoyl}propanamido)butyl]carbamoyl}propyl]carbamoyl}amino)pentanedioic acid
Matched Description: … of this compound, flotufolastat F-18 has a faster clearance from blood pool, liver, and kidney, and ... a good distinction between primary-tumor activity and bladder background activity. ... PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer half-life and
Approved
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, Fasciola hepatica, which is also known as “the common liver fluke” or “the...
Approved
Investigational
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …
Eplontersen is a transthyretin-directed antisense oligonucleotide with 3 covalently linked e N-acetyl galactosamine residues for hepatic delivery. It was previously investigated as a potential treatment for hereditary transthyretin-mediated amyloidosis. Hereditary transthyretin-mediated amyloidosis is caused primarily by pathogenic variants of the TTR gene, leading to the formation and thus accumulation of...
Approved
Investigational
Matched Description: … thus accumulation of insoluble and misfolded amyloid in multiple organs, although wild-type misfolded ... [A262985] As eplontersen targets both the WT and mutant TTR, it poses tremendous promises as a treatment ... NEURO-TTRansform study, where a consistent improvement in the Neuropathy Impairment Score +7 (mNIS+7) and
Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, desvenlafaxine, works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and...
Approved
Matched Description: … Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). ... Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine ... treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …
Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). Janus kinases are intracellular enzymes involved in transduction pathways that regulate hematopoiesis and immune cell function. The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of...
Approved
Investigational
Matched Description: … Janus kinases are intracellular enzymes involved in transduction pathways that regulate hematopoiesis and ... [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway ... plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases, including …
Indium In-111 Chloride is a diagnostic radiopharmaceutical agent intended for radiolabeling OncoScint (satumomab pendetide) or ProstaScint (capromab pendetide) used for in vivo diagnostic imaging procedures and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures. It is supplied as a sterile, pyrogen-free solution of Indium ("'In) Chloride in...
Approved
Matched Description: … satumomab pendetide) or ProstaScint (capromab pendetide) used for _in vivo_ diagnostic imaging procedures and
Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
Approved
Illicit
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …
Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.
Approved
Experimental
Matched Description: … Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ... Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine …
Displaying drugs 2351 - 2375 of 14951 in total