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Displaying drugs 226 - 250 of 9713 in total

Iohexol

Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Approved
Matched Description: … Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. …
Matched Categories: … Diagnostic Uses of Chemicals …

Chorionic Gonadotropin (Human)

Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta. Endogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. This allows the corpus luteum to continuously secrete the hormone progesterone during the first...
Approved
Vet approved
Matched Description: … of the corpus luteum during the beginning of pregnancy. ... HCG is composed of an alpha and a beta sub-unit. ... cells (Leydig cells) of the testis to produce androgens. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Cocaine

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of...
Approved
Illicit
Matched Description: … An alkaloid ester extracted from the leaves of plants including coca. ... its reinforcing effects is thought to involve inhibition of dopamine uptake. ... It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse …
Matched Categories: … Esters of Benzoic Acid ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Baricitinib

Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune responses. Baricitinib was...
Approved
Investigational
Matched Description: … baricitinib for the treatment of COVID-19 in May 2022. ... By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune ... Baricitinib was first approved by the European Commission (EC) in February 2017 for the treatment of …

Nevirapine

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Approved
Matched Description: … reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances ... Antivirals used in combination for the treatment of HIV infections …

Varicella zoster vaccine (recombinant)

Recombinant zoster vaccine, manufactured as the product Shingrix by GlaxoSmithKline, is an adjuvanted non-live recombinant vaccine indicated for prevention of shingles. First approved in October 2017 by the Food and Drug Administration, Shingrix is the preferred vaccine for preventing varicella zoster infection in people aged 50 years and older, replacing...
Approved
Investigational
Matched Description: … Following initial infection of VZV and resolution of Chickenpox as a child, VZV then lies dormant within ... of varicella zoster virus (VZV). ... One of the most common complications associated with shingles is the development of Post-Herpetic Neuralgia …

Bezlotoxumab

Bezlotoxumab is a fully humanized ImmunoglobulinG1 (IgG1) kappa monoclonal antibody that binds to Clostridium difficile toxin B and neutralizes its effects. First approved by the FDA on October 21, 2016, bezlotoxumab is used to reduce the recurrence of C. difficile infection. On November 22, 2016, the Committee for Medicinal Products...
Approved
Investigational
Matched Description: … [A260106] The drug was granted full approval by the EMA on January 18, 2017.[L47191] ... Agency recommended the granting of a marketing authorization. ... First approved by the FDA on October 21, 2016,[A260106] bezlotoxumab is used to reduce the recurrence of …

Ansuvimab

Infection with pathogenic filoviruses, such as Zaire ebolavirus (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as 90%.[A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development. However, to date, the most successful...
Approved
Investigational
Matched Description: … However, to date, the most successful method appears to be the development of monoclonal antibodies ( ... surface glycoprotein, as evidenced by the previously approved INMAZEB™ (REGN-EB3, a cocktail of ... [A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development …

Rifaximin

Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of...
Approved
Investigational
Matched Description: … the drug will not pass the gastrointestinal wall into the circulation as is common for other types of ... in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel ... It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction …

Sulfametopyrazine

Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.
Approved
Withdrawn
Matched Categories: … combinations of sulfonamides …

Trichlormethiazide

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Approved
Vet approved
Matched Description: … A thiazide diuretic with properties similar to those of hydrochlorothiazide. …
Matched Categories: … combinations of sulfonamides …

Procarbazine

An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Approved
Investigational
Matched Description: … combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Procaine benzylpenicillin

Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It...
Approved
Vet approved
Matched Description: … It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin ... Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many ... combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of …
Matched Mixtures name: … Bicillin C-R 900/300 …
Matched Categories: … combinations of penicillins …

Bictegravir

Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet.
Approved
Investigational
Matched Description: … Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Iothalamic acid

Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent.
Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Plazomicin

Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Description: … However, acquired resistance of aminoglycosides may arise through over expression of efflux pumps and ... The structure of plazomicin was established via appending hydroxylaminobutyric acid to [DB12604] at position ... 28th, 2018, plazomicin sulfate was approved by the FDA for use in adult patients for the treatment of …

Naldemedine

Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of DB00704 to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and...
Approved
Investigational
Matched Iupac: … oxadiazol-5-yl)propan-2-yl]-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18 …
Matched Description: … It is a modified form of [DB00704] to which a side chain has been added to increase molecular weight ... Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation …

Abaloparatide

Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) and an agonist at the parathyroid hormone type 1 (PTH1) receptor. It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34. Abaloparatide and PTHrP share the first 21 amino acids...
Approved
Investigational
Matched Description: … Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) [A256778] and an ... [L740] It was first approved by the FDA on April 28, 2017,[A256748] for the treatment of osteoporosis …

Isradipine

Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity...
Approved
Investigational
Matched Description: … used class of CCBs. ... the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells ... Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely …

Ledipasvir

Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Description: … Although its exact mechanism of action is unknown, it is postulated to prevent hyperphosphorylation of ... Lack of significant side effects and short duration of therapy is a considerable advantage over older ... reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma …
Matched Categories: … Antivirals for treatment of HCV infections …

Chlorpropamide

Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class...
Approved
Investigational
Matched Description: … Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination ... Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the ... of retinopathy (UKPDS-33). …
Matched Categories: … combinations of sulfonamides …

Benzylpenicillin

Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered...
Approved
Vet approved
Matched Description: … Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram …
Matched Mixtures name: … Bicillin C-R 900/300 …
Matched Categories: … combinations of penicillins …

Simeprevir

Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United...
Approved
Matched Description: … reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Prior to initiation of treatment with [DB00008] and [DB00811], screening for the presence of virus with ... virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of …
Matched Categories: … combinations of sulfonamides ... Antivirals for treatment of HCV infections …

Atezolizumab

Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … [L7489] Atezolizumab was granted FDA approval on 18 October 2016. ... inhibition of immune responses seen in some cancers. ... The rest of atezolizumab indications remain unaffected.[L44246] …
Displaying drugs 226 - 250 of 9713 in total