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Displaying drugs 2476 - 2500 of 15172 in total

Favipiravir

Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza.[A191688,A191721] The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes.[A191688,A191772,A191775] Not only does favipiravir inhibit...
Approved
Investigational
Matched Description: … [A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but ... the drug has shown promise in the treatment of avian influenza, and may be an alternative option for ... antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and …

Dimethicone 410

Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%....
Approved
Matched Description: … It is reported that the term dimethicone includes the notation of polydimethylsiloxane and trimethylsiloxy-terminated …

Anagrelide

Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythemia treatments (e.g....
Approved
Matched Description: … [busulfan], [hydroxyurea]) and may be better tolerated.[A214274] …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Deferiprone

Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired....
Approved

Alirocumab

Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and statin treatment. It is a human monoclonal antibody part of the family of the PCSK9 inhibitors which...
Approved
Matched Description: … high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and ... FDA approval was contingent on the completion of further clinical trials to better determine efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Midostaurin

Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors . It was...
Approved
Investigational
Matched Description: … characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and ... It was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Tenapanor

Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). It was first designed and synthesized in 2012. As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and...
Approved
Investigational
Matched Description: … [L8558] It was first designed and synthesized in 2012. ... currently only medication within its class[A185489,A185492,A185495] and therefore exists as a novel ... A185492] As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and …
Matched Categories: … Alimentary Tract and Metabolism …

Tranylcypromine

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising...
Approved
Investigational
Matched Description: … monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and ... It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). ... Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1- …

Desloratadine

Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Approved
Investigational
Matched Description: … Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral ... Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter …
Matched Categories: … Loratadine and derivatives …

Rasagiline

Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Approved
Matched Description: … Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's …

Temoporfin

Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2001. It is currently available under the brand name Foscan.
Approved
Investigational
Matched Description: … Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Foreskin fibroblast (neonatal)

Foreskin fibroblast-like stromal cells (FDSCs) are progenitors isolated from human tissue that can differentiate into various cell types . Also known as Dermagraft, this device is a cryopreserved human fibroblast-derived dermal substitute. Composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold, it effectively supports wound healing . Dermagraft has only...
Approved
Matched Description: … , as well as New Zealand and Australia. ... The impact of diabetic foot ulcers (DFU) on individuals and society is devastating. ... Composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold, it effectively supports …

Sodium bisulfite

Sodium bisulfite has been used externally for parasitic skin diseases and as a gastrointestinal antiseptic.
Approved
Matched Description: … Sodium bisulfite has been used externally for parasitic skin diseases and as a gastrointestinal antiseptic …

Maprotiline

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used...
Approved
Investigational
Matched Description: … TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and ... be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Yellow fever vaccine

Yellow fever vaccine prevents against Yellow Fever, a viral hemorrhagic disease caused by the transmission of a flavivirus through the bite of an infected mosquito. Symptoms of Yellow fever can range from asymptomatic, to mild flu-like illness, to more severe symptoms such as shock, jaundice, internal bleeding, and organ failure...
Approved
Investigational
Matched Description: … of yellow fever in pediatric patients 9 months of age and older. ... Interestingly, Yellow fever got its name from the characteristic yellowing of the skin and eyes that ... Vaccination with Yellow Fever vaccine is therefore considered to be the most important and effective …

Kinetin

Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. It was shown to naturally exist in DNA of organisms including humans and various plants. While kinetin is used in tissue cultures to produce new plants, it is also found in cosmetic products as an anti-aging...
Approved
Matched Description: … Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. ... It was shown to naturally exist in DNA of organisms including humans and various plants. …

Calfactant

Calfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline. Each milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and 0.65mg...
Approved
Matched Description: … 0.65mg of proteins including surfactant-associated proteins B and C. ... phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and ... decrease the incidence of respiratory distress syndrome, mortality due to respiratory distress syndrome, and …

Allogeneic processed thymus tissue

Allogeneic processed thymus tissue is used for immune reconstitution in immune disorders where the patients are severely immunocompromised due to the absence of a functional thymus, such as congenital athymia. As part of the immune system, the thymus is an organ responsible for the maturation and selection of T cells...
Approved
Matched Description: … As part of the immune system, the thymus is an organ responsible for the maturation and selection of ... T cells [A239814]; thus, patients without a functional thymus experience profound immunodeficiency and ... [L38929] Congenital athymia is a rare condition that leads to the absence of a thymus at birth and a …

Pirbuterol

Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is...
Approved
Matched Description: … In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential ... Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release …

Trifluoperazine

A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Approved
Investigational
Matched Description: … It is used as an antipsychotic and an antiemetic. …

Methoxamine

An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system.
Approved
Investigational
Matched Categories: … Adrenergic and Dopaminergic Agents …

Fenoldopam

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Approved
Matched Categories: … Adrenergic and Dopaminergic Agents …

Streptozocin

An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Approved
Investigational
Matched Description: … It is used as an antineoplastic agent and to induce diabetes in experimental animals. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Isosorbide

Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the isosorbide mononitrate and isosorbide dinitrate forms, and is used for the prevention of...
Approved
Investigational
Matched Description: … isosorbide dinitrate] forms, and is used for the prevention of angina. ... Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [ …

Chromium Cr-51

Chromium Cr-51 is an isotope of chromium that has been used as a radioactive label for decades. It is used as a diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,[A249765,A249770] and in hematology to determine red blood cell volume or mass, study the red blood cell survival time...
Approved
Matched Description: … in hematology to determine red blood cell volume or mass, study the red blood cell survival time and ... diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,[A249765,A249770] and …
Displaying drugs 2476 - 2500 of 15172 in total