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Displaying drugs 2826 - 2850 of 9732 in total

Naratriptan

Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.
Approved
Investigational
Matched Description: … It is typically used for the treatment of migraine headaches. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Isotretinoin

Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the...
Approved
Matched Description: … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. …
Matched Categories: … Retinoids for Treatment of Acne …

Oxymorphone

An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia,...
Approved
Investigational
Vet approved
Matched Iupac: … 13R,17S)-10,17-dihydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18 …
Matched Description: … An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough ... It is used in the treatment of moderate to severe pain, including pain in obstetrics. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ergometrine

An ergot alkaloid with uterine and vascular smooth muscle contractile properties.
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Racepinephrine

Racepinephrine is a racemic mixture consisting of d-DB00668 and l-DB00668 enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingredient in...
Approved
Matched Description: … wheezing, tightness of chest and shortness of breath. ... It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including ... Racepinephrine is a racemic mixture consisting of d-[DB00668] and l-[DB00668] enantiomers. …
Matched Mixtures name: … Super Sulpak R 45 ... Super Sulpak R 46 ... Super Sulpak R 44 …

Lubiprostone

Lubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. Activation of these channels promotes the secretion of a chloride-rich fluid that soften...
Approved
Investigational
Matched Description: … Activation of these channels promotes the secretion of a chloride-rich fluid that soften the stool, increase ... Lubiprostone is a medication used in the management of idiopathic chronic constipation. ... lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of …

Voxelotor

Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications arising from the...
Approved
Investigational
Matched Description: … The EMA approved the use of voxelotor for the treatment of hemolytic anemia associated with sickle cell ... Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. ... This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of …

alpha-Linolenic acid

Alpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition.
Approved
Investigational
Nutraceutical
Matched Description: … It is a component of many common vegetable oils and is important to human nutrition. …

Avatrombopag

Avatrombopag (Doptelet), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require platelet transfusions before surgical procedures to decrease the risk of bleeding. Thrombocytopenia is a...
Approved
Investigational
Matched Description: … liver disease or a consequence of interferon-based antiviral therapy. ... administered treatment option for patients with chronic liver disease, allowing a large population of ... chronic liver disease often require platelet transfusions before surgical procedures to decrease the risk of …

Cobicistat

Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered agents that are metabolized...
Approved
Matched Description: … More specifically, cobicistat is indicated to increase systemic exposure of atazanavir or darunavir ( ... once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 ... enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances ... Antivirals used in combination for the treatment of HIV infections …

Filgrastim

Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in E. Coli. Human...
Approved
Matched Description: … action of the drug. ... Filgrastim mimics the biological actions of G-CSF to increase the levels of neutrophils in the blood. ... [L40719] It has a number of therapeutic uses, including the management and prevention of infections and …
Matched Products: … LEUCOSTIM(R) 300 MCG/PREFILLED SYRINGE ... LEUCOSTIM(R) 480 MCG/PREFILLED SYRINGE …

Fexofenadine

Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H1 receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamines, such as diphenhydramine, which readily bind to off-targets...
Approved
Investigational
Matched Description: … Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various ... [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a …
Matched Products: … FEXOFF-R …

Ritonavir

Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritonavir and other protease inhibitors. It is now more commonly used as a...
Approved
Investigational
Matched Description: … American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America ... Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. ... It is now more commonly used as a booster of other protease inhibitors and is available in both liquid …
Matched Mixtures name: … ANCEF ® R ... ZANAVIR-R ... ANCEF ® R …
Matched Categories: … Antivirals for treatment of HCV infections ... Metabolic Side Effects of Drugs and Substances ... Antivirals used in combination for the treatment of HIV infections …

Triethylenetetramine

Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, spermidine and spermine. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved by the FDA in 1985...
Approved
Investigational
Matched Description: … It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. ... [L41730] TETA has been investigated in clinical trials for the treatment of heart failure in patients …

Rifamycin

Rifamycin is the prime member of the rifamycin family which are represented by drugs that are a product of fermentation from the gram-positive bacterium Amycolatopsis mediterranei, also known as Streptomyces mediterranei. The parent compound of rifamycin was rifamycin B which was originally obtained as a main product in the presence...
Approved
Investigational
Matched Description: … presence of diethylbarburitic acid. ... SV there was the first antibiotic used intravenously for the treatment of tuberculosis. ... Rifamycin is the prime member of the rifamycin family which are represented by drugs that are a product …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Efanesoctocog alfa

Efanesoctocog alfa (BIVV001) is a recombinant factor VIII (FVIII) analogue fusion protein used for the routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding episodes in patients with hemophilia A. The use of FVIII replacement products is beneficial in patients with hemophilia A; however, their quality...
Approved
Investigational
Matched Description: … To extend the half-life of FVIII, efanesoctocog alfa is fused to dimeric Fc, a D'D3 domain of VWF, and ... their quality of life can be affected due to frequent doses. ... bleeding and on-demand treatment and control of bleeding episodes in patients with hemophilia A. …

Technetium Tc-99m oxidronate

Technetium Tc-99m oxidronate, also known as 99mTc-methylene diphosphonate, is a radiopharmaceutical agent. A radiopharmaceutical is defined as a medicinal formulation containing radioisotopes that are used in major clinical areas for diagnosis and/or therapy. The radiopharmaceuticals based on technetium-99m are widely used for diagnostic purposes because 99mTc has a versatile chemistry...
Approved
Matched Description: … [L1140] It was developed by Mallinkrodt nuclear and FDA approved on February 18, 1981. ... [L1138] These complexes are formed by the binding of 99mTc to metal atoms of an organic molecule. ... The group oxidronate falls into the category of diphosphonates whose structure allows them to bind to …

Boceprevir

Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Withdrawn
Matched Description: … alter the affinity of the drug for NS3/4A or the activity of the enzyme itself. ... another class of DAAs [A19593]. ... The barrier for develoment of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors, …
Matched Categories: … Antivirals for treatment of HCV infections …

Dolutegravir

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare...
Approved
Matched Description: … of the viral genome into the host cell (INSTI). ... Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration ... [L1035] On November 21, 2017, dolutegravir, in combination with rilpivirine, was approved as part of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Dolasetron

Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is not shown to have activity at other...
Approved
Investigational
Matched Description: … Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting ... associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Calcium chloride

Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice...
Approved
Matched Description: … Calcium chloride is an ionic compound of calcium and chlorine. ... Because of its hygroscopic nature, it must be kept in tightly-sealed containers. ... It can be produced directly from limestone, but large amounts are also produced as a by-product of the …
Matched Mixtures name: … Plasma-Lyte R ... Isolyte R In 5% Dextrose ... CAPD 18 …

Aminoglutethimide

An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale,...
Approved
Investigational
Matched Description: … An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of ... It also blocks the conversion of androgens to estrogens. ... Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. …

Clomipramine

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals,...
Approved
Investigational
Vet approved
Matched Description: … TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... See toxicity section below for a complete listing of side effects. ... Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Givinostat

Givinostat is a small molecule histone deacetylase (HDAC) inhibitor. It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies. In the context of muscular dystrophy, inhibitors of HDAC appear...
Approved
Investigational
Matched Description: … In the context of muscular dystrophy, inhibitors of HDAC appear to exert their therapeutic effects by ... 6 years of age with Duchenne muscular dystrophy (DMD). ... It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease …

Rutin

A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.
Approved
Experimental
Investigational
Displaying drugs 2826 - 2850 of 9732 in total