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Displaying drugs 276 - 300 of 8039 in total

Glycol salicylate

Glycol salicylate, also known as 2-hydroxyethyl salicylate, is a benzoate ester formed from the condensation of the carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol. It is found as an active ingredient and topical analgesic in patches used to provide relief for mild to...
Approved
Matched Description: … the carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol. ... This ingredient is an important component of many topical creams and sprays for the relief of aches, ... of mild to moderate pain [L2691]. …

Fulvestrant

Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. While it is used as monotherapy for the...
Approved
Investigational
Matched Description: … Fulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal ... While it is used as monotherapy for the treatment of breast cancers, it is also used in combination with ... [alpelisib] for the treatment of HR-positive, human epidermal growth factor receptor 2 (HER2)-negative …

Protamine sulfate

Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps the only viable option for reversing the anticoagulant effect of heparin use for over 77 years [A174778,...
Approved
Matched Description: … the agent could decrease the safety of the procedure or worsen the recovery of a patient after the procedure ... are managed with the use of protamine sulfate [A174778]. ... the anionic nature of heparin and its own cationic state [A174778, A174781, L5371]. …

Butamben

Butamben is a local anesthetic in the form of n-butyl-p-aminobenzoate. Its structure corresponds to the standard molecule of a hydrophilic and hydrophobic domain separated by an intermediate ester found in most of the local anesthetics. Due to its very low water solubility, butamben is considered to be suitable only for...
Approved
Withdrawn
Matched Description: … Butamben is a local anesthetic in the form of n-butyl-p-aminobenzoate. ... by an intermediate ester found in most of the local anesthetics. ... [A27147] Its structure corresponds to the standard molecule of a hydrophilic and hydrophobic domain separated …

Abarelix

Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.
Approved
Investigational
Withdrawn

Glasdegib

Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionality. The great lipophilicity of this group of compounds...
Approved
Investigational
Matched Description: … [A258493] Aberrant of Hh signaling is one of the main pathophysiologies of AML, with observed overexpression ... [A40310] The great lipophilicity of this group of compounds brought interest to further modification. ... or constitutive activation of SMO. …

Eliglustat

Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher disease, the accumulation of glucosylceramide leads to...
Approved
Investigational
Matched Description: … The results of this test dictate eliglustat dosing recommendations for each type of patient. ... In patients with Gaucher disease, the accumulation of glucosylceramide leads to the formation of Gaucher ... [L41404,A7634] Enzyme replacement continues to be the standard of care for the treatment of type 1 Gaucher …

Chlorpromazine

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Approved
Investigational
Vet approved
Matched Description: … Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Succimer

A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
Approved

Betamethasone

Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.
Approved
Vet approved
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Cevimeline

Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Approved
Matched Description: … It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's …

Choline C 11

Choline C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes. It was developed by MCPRF and FDA first approved in September 2012.
Approved
Investigational
Matched Description: … phospholipids which are essential components of all cell membranes. ... 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of …

Stiripentol

Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzymes. However, its clinical efficacy as...
Approved
Matched Description: … [A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the ... epilepsies stems from its inhibitory action on CYP enzymes, as stiripentol reduces the degradation of ... Stiripentol may also exhibit direct anticonvulsant properties, although the exact mechanism of action …

Tasimelteon

Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of...
Approved
Investigational
Matched Description: … In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle ... Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour ... By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon …

Dihydroergocristine

Dihydroergocristine is part of the ergoloid mixture products. It is a semisynthetic ergot alkaloid and thus, it is characterized by a structural skeleton formed by an alkaloid ergoline. To know more about ergoloid mixtures, please visit DB01049.
Approved
Experimental
Matched Description: … Dihydroergocristine is part of the ergoloid mixture products. …

Diosmin

Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from hesperidin. It is used for the improvement of capillary fragility or...
Approved
Investigational
Matched Description: … It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous ... pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of …

Vilanterol

Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug administration). Vilanterol was...
Approved
Matched Description: … of the release of hypersensitivity mediators from mast cells in the lungs. ... dosing regimens or complexities of drug administration). ... long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of …

Florbetaben F-18

Florbetaben is a fluorine-18 (18F)-labeled stilbene derivative used for Positron Emission Tomography (PET) imaging of the brain. It is used for the non-invasive detection of the density of ß-amyloid neuritic plaques in the brain of adult patients with cognitive impairment.
Approved
Matched Description: … It is used for the non-invasive detection of the density of ß-amyloid neuritic plaques in the brain of ... a fluorine-18 (18F)-labeled stilbene derivative used for Positron Emission Tomography (PET) imaging of …

Esomeprazole

Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison...
Approved
Investigational
Matched Description: … Esomeprazole is the s-isomer of [DB00338], which is a racemate of the S- and R-enantiomer. ... or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions ... This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of …

Gemifloxacin

Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. ... Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of ... Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase …

Diltiazem

Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle...
Approved
Investigational
Matched Description: … Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug ... It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx ... clinically as an antihypertensive, anti-arrhythmic, and as an anti-anginal agent [L6289] for the management of …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Prednisolone

Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955.
Approved
Vet approved
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Atazanavir

Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day)...
Approved
Investigational
Matched Description: … Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). ... Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class ... requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Abiraterone

Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 2011, respectively. It is used to treat metastatic...
Approved
Matched Description: … Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17 …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Fenoldopam

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Approved
Displaying drugs 276 - 300 of 8039 in total