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Displaying drugs 3001 - 3025 of 9627 in total
Zuranolone
Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAA receptors. Unlike other more common GABAA positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and extrasynaptic GABAA conductance due to binding to a non-benzodiazepine site on the receptor.[A260776,A260786] Zuranolone was...
Approved
Experimental
Matched Description: … Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAAof an oral, once-daily dosing formulation. ... [A260776,A260786] Zuranolone was designed with a pharmacological profile of a neuroactive steroid in …
Methylene blue
Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered...
Approved
Investigational
Matched Description: … The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult ... The drug is of potential interest for the treatment of patients with Alzheimer's disease. ... Aberdeen and TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Ipratropium
Ipratropium is a quaternary ammonium derivative of atropine that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its first monotherapy product was FDA approved...
Approved
Experimental
Matched Description: … Ipratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic ... Ingelheim and its first monotherapy product was FDA approved in 1986, while the combination product of …
Cefotaxime
Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Approved
Matched Description: … In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. …
Pazopanib
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Approved
Matched Description: … Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic …
Vonicog alfa
Vonicog alfa is a recombinant von Willebrand factor manufactured by Baxalta. It was FDA approved in December 2015. The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg. By the EMA, vonicog alfa is still under clinical analysis.
Approved
Investigational
Matched Description: … [A32230] The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg …
Voxelotor
Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications arising from the...
Approved
Investigational
Matched Description: … The EMA approved the use of voxelotor for the treatment of hemolytic anemia associated with sickle cell ... Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. ... This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of …
Ademetionine
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Approved
Investigational
Nutraceutical
Matched Description: … It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. …
Triethylenetetramine
Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, spermidine and spermine. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved by the FDA in 1985...
Approved
Investigational
Matched Description: … It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. ... [L41730]
TETA has been investigated in clinical trials for the treatment of heart failure in patients …
Trastuzumab deruxtecan
Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of...
Approved
Investigational
Matched Description: … HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of ... peptide linker used to bind the antibody and drug in this product distinguishes it from other members of …
Digoxin
Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also...
Approved
Matched Description: … Digoxin is one of the oldest cardiovascular medications used today. ... [A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. ... They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as …
Isavuconazonium
Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it...
Approved
Investigational
Matched Description: … administration of other antifungals such as voriconazole and posaconazole, eliminating concerns of nephrotoxicity ... triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of ... [A38834] It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and …
Atorvastatin
Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,...
Approved
Matched Description: … [A181087, A181406] The increasing use of this class of drugs is largely attributed to the rise in cardiovascular ... and lipid levels, and ultimately reduce the risk of cardiovascular disease. ... Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. …
Spironolactone
Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including...
Approved
Matched Description: … [L44602] Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne ... Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of …
Alprostadil
Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an intraurethral suppository, for the treatment of erectile dysfunction, and it is used in men for whom oral treatment...
Approved
Investigational
Matched Description: … Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator ... After administration, alprostadil promotes smooth muscle relaxation of the corpus cavernosal. ... In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection …
Ferrous sulfate anhydrous
Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is...
Approved
Matched Description: … the formation of erythrocytes, also known as red blood cells. ... anemia is a large public health concern worldwide, especially in young children, infants, and women of ... [A190528]
Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. …
Rurioctocog alfa pegol
Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor. Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated risk for excessive bleeding caused by spontaneous or secondary events like trauma...
Approved
Experimental
Matched Description: … The presence of the polyethylene glycol (PEG) moiety increases the plasma half-life of the drug, thereby ... increasing the drug's duration of action. ... [A245149] Hemophilia A is the most common inherited bleeding disorder leading to deficiency of factor …
Albutrepenonacog alfa
Albutrepenonacog alfa (rIX-RFP) is a recombinant fusion protein that links a recombinant coagulation factor IX (rFIX) with a recombinant human albumin (rAlbumin). It was developed by CSL Behring Canada, Inc and approved by Health Canada on April 26, 2017. It was also approved by FDA and EMA in 2016. It...
Approved
Matched Description: … It is currently marketed in the forms of 250, 500, 1000 and 2000 IU/vial.[L2305] …
Glatiramer
Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties. Originally, glatiramer acetate was designed as a...
Approved
Investigational
Matched Description: … , and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. ... Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine ... [A248870] Originally, glatiramer acetate was designed as a stimulant of myelin basic protein (MBP), a …
Gabapentin enacarbil
Gabapentin enacarbil is marketed under the name Horizant. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Approved
Investigational
Matched Description: … It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS …
Ferric sulfate
Ferric sulfate has the molecular formula of Fe2SO4, and it is a dark brown or yellow chemical agent with acidic properties. It is produced by the reaction of sulfuric acid and an oxidizing agent. It is used in different fields such as dermatology, dentistry and it is thought to present...
Approved
Matched Description: … It is produced by the reaction of sulfuric acid and an oxidizing agent. ... Ferric sulfate has the molecular formula of Fe2SO4, and it is a dark brown or yellow chemical agent with …
Acemetacin
Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin. It was developed by...
Approved
Investigational
Matched Description: … Acemetacin is a carboxymethyl ester of indometacin. ... acetamicin led to the formation of indomethacin and it kept the same side effects. ... provide a safer drug but other than the amelioration on the gastrointestinal effects, the metabolism of …
Tranexamic acid
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Approved
Matched Description: … prevention of major bleeding. ... Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and ... It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent …
Anidulafungin
Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile to caspofungin.
Approved
Investigational
Displaying drugs 3001 - 3025 of 9627 in total