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Displaying drugs 351 - 375 of 5907 in total
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic...
Approved
Nutraceutical
Matched Synonyms: … L-Ascorbic Acid ... L-(+)-ascorbic acid ... L-Ascorbate …
Matched Name: … Ascorbic acid
Matched Iupac: … (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one …
Matched Description: … Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and ... It is found naturally in citrus fruits and many vegetables. ... Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic …
Matched Mixtures name: … Zinc Lozenges With Vitamin C and Non-medicinal Echinacea ... Super 7 Vitamin and Mineral Supplement ... Magnum-75 Vitamin and Mineral Supplement …
Matched Categories: … ascorbic acid (vit C) and calcium ... Alimentary Tract and Metabolism ... Diet, Food, and Nutrition ... Genito Urinary System and Sex Hormones ... Vitamin C and analogues …
Matched Products: … Sodium Ascorbate and Ascorbic Acid Pwr ... ACIDO ASCORBICO INYECCION BP AMPOLLA POR 5 ML ( 100MG/ML) ... Vit.c With N-M.bioflav.rose Hips and Rutin …
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Synonyms: … 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine ... 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine …
Matched Description: … It inhibits gastric acid secretion, as well as pepsin and gastrins output. …
Matched Salts cas: … 70059-30-2 …
Matched Mixtures name: … Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40% ... Cimetidine 5% / Ibuprofen 2% / Salicylic Acid 17% …
Matched Categories: … Alimentary Tract and Metabolism ... Metabolic Side Effects of Drugs and Substances ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) ... Acid Reducers ... Gastric Acid Lowering Agents …
Matched Products: … Up and Up Acid Reducer ... Tagamet Liq 300mg/5ml ... ดูโอดิน 300
Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.
Approved
Vet approved
Matched Iupac: … ,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one ... (1R,2S,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H …
Matched Description: … Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. ... [A192444] It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally ... [A192444] Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity. …
Matched Salts cas: … 151-73-5 …
Matched Mixtures name: … BACTAFUZ-B Fusidic Acid and Betamethasone Valerate Cream ... Marbeta L Kit ... Marbeta L Kit …
Matched Salts name: … Betamethasone acetate
Matched Categories: … Sex Hormones and Insulins ... Alimentary Tract and Metabolism ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... betamethasone and mydriatics ... betamethasone and antiseptics …
Matched Products: … Betnesol Eye and Ear Drops ... Betnesol Eye and Ear Drops 0.1% ... BETAMETHASON ACIS CRINALE …
Wild boar hair is used in allergenic testing.
Approved
Matched Name: … Sus scrofa hair …
Matched Mixtures name: … Hog Hair and Epithelia …
Sus scrofa placenta is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Pork Placenta …
Matched Name: … Sus scrofa placenta …
Matched Description: … Sus scrofa placenta is an animal extract used in some OTC (over-the-counter) products. …
Xaluritamig is a novel humanized bispecific T cell recruiting antibody cross-reactive to human and nonhuman primate STEAP1 and CD3.
Investigational
Matched Synonyms: … STEAP family member 1, six transmembrane epithelial antigen of the prostate 1, STEAP1 metalloreductase) and ... with peptide linker (GGGGS)2 fusion protein with immunoglobulin anti-(human CD3 antigen) (human-Mus ... lysine], anti-(human metalloproteinase STEAP1) (human-Mus musculus clone 2F3.013 N67Q γ1-chain) fusion protein
Matched Description: … primate STEAP1 and CD3. ... Xaluritamig is a novel humanized bispecific T cell recruiting antibody cross-reactive to human and nonhuman …
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched International brands: … Heparin LEO
Matched Synonyms: … Heparinic acid
Matched Description: … coagulation enzymes thrombin (factor IIa) and factor Xa. ... It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates ... UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. …
Matched Mixtures name: … Heparin Sodium and Dextrose 5% Inj USP ... Heparin Sod and 0.9% Sod Chloride Inj ... Heparin Sodium & 5% Dextrose Injection Liq
Matched Categories: … Blood and Blood Forming Organs ... Heparin and similars …
Matched Products: … Heparin Sodium and Sodium Chloride ... Heparin Sodium and Dextrose ... DBL HEPARIN SODIUM INJECTION BP (PORCINE) 35,000 iu/35 ml …
A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Approved
Investigational
Matched Synonyms: … beta-L-2',3'-Dideoxy-3'-thiacytidine ... beta-L-3'-Thia-2',3'-dideoxycytidine ... 2',3'-Dideoxy-3'-thiacytidine …
Matched Description: … A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon ... It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). …
Matched Mixtures name: … FORSTAVIR-LE ( Efavirenz 600 mg, Lamivudine 300 mg and Tenofovir Disoproxil Fumarate 300 mg ) Film-coated ... ABACAVIR .LAMIVUDINA +ZIDOVUDINATABLETAS 750 MG ... ARROW LZ (Lamivudine 150mg and Zidovudine 300mg ) Tablets …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleic Acid Synthesis Inhibitors ... lamivudine and abacavir ... lamivudine and dolutegravir ... zidovudine and lamivudine …
Matched Products: … Lamivudine and Zidovudine ... LMV ... Arrow-L-150 (Lamivudine Tablets 150mg) …
Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against both compared to third-generation antibiotics.[A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused by multi-resistant microorganisms such as Pseudomonas aeruginosa, and is also indicated...
Approved
Investigational
Matched Synonyms: … (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium …
Matched Iupac: … -1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidin-1-ium ... 1-{[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia …
Matched Description: … Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against ... [A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused ... by multi-resistant microorganisms such as _Pseudomonas aeruginosa_, and is also indicated for the empirical …
Matched Categories: … cefepime and amikacin …
Matched Products: … Cefepime Hydrochloride and Dextrose …
Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of...
Approved
Vet approved
Withdrawn
Matched Description: … Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental ... [L11512] It is one of the most common skin and mucous membrane antiseptic agents in use today. ... [A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two …
Matched Mixtures name: … Re-liv oral lotion ... RinsCap CIPA ( CHLORHEXIDINE GLUCONATE 2% w/v and ISOPROPYL ALCOHOL 70% v/v ) ... Baxedin 2% - 70% …
Matched Salts name: … Chlorhexidine acetate
Matched Categories: … Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Biguanides and Amidines ... Antiinfectives and Antiseptics for Local Oral Treatment ... Mouthwashes and Gargles …
Matched Products: … 3M AVAGARD 9232 ANTISEPTIC HAND AND BODY WASH CLORHEXIDINE GLUCONATE 2% W/W SOLUTION BOTTE . ... Foster and Thrive ... DERMCARE PYOHEX 30g/L MEDICATED SHAMPOO …
Sus scrofa skin or pelt is used in allergenic testing.
Approved
Matched Name: … Sus scrofa skin …
Matched Description: … Sus scrofa skin or pelt is used in allergenic testing. …
Matched Mixtures name: … Hog Hair and Epithelia …
Matched Products: … PiGe ll Real Skin Eye ... PiGe ll Real Skin Neck Pack ... PiGe ll Real Skin Mask Pack …
Experimental
Matched Synonyms: … Pork, stomach …
Matched Name: … Sus scrofa stomach …
Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail. It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation. The ubidecarenone is...
Approved
Investigational
Nutraceutical
Matched Iupac: … 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38 ... -decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione …
Matched Description: … From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number ... [A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative ... [L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant …
Matched Mixtures name: … Super 7 Vitamin and Mineral Supplement ... Q 10 Suprabio +L-Carnitine ... Vitamin E and Coq10 …
Matched Categories: … Diet, Food, and Nutrition ... Enzymes and Coenzymes ... Electron Transport Chain Complex Proteins
Matched Products: … Coenzyme Q10 30 mg L-V-caps ... Coenzyme Q10 With Hawthorn Extract and Citrus Bioflavonoids ... Cellsparc 360
Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to neridronic acid and alendronic acid. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as ibandronic acid, zoledronic acid, minodronic acid, and risedronic acid are becoming...
Approved
Matched Synonyms: … Acide pamidronique ... Pamidronic acid ... Acido pamidronico …
Matched Name: … Pamidronic acid
Matched Iupac: … (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
Matched Description: … ] and [alendronic acid]. ... ], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular. ... [A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835] …
Matched Salts name: … Pamidronate Disodium
Matched Categories: … Drugs Affecting Bone Structure and Mineralization ... pamidronic acid
Matched Products: … Aredia Liq Inj 3mg/ml ... MENEDRON-L 30 MG IV ENJEKSİYONLUK LİYOFİLİZE TOZ İÇEREN FLAKON (3 FLAKON) ... Pamidronate Disodium Omega 3 mg/ml …
Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as ritonavir for the effective management of HIV-1 infection. As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard HIV therapy.[A2278,A2281] It was initially approved by the FDA in 2006. Darunavir is being...
Approved
Matched Synonyms: … {(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3aS ... [(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid ... (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy …
Matched Iupac: … (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido …
Matched Description: … [A191682] Clinical trials are underway and are expected to conclude in August 2020.[L12066] ... Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as [ritonavir] ... [L9227] As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard …
Matched Salts cas: … 635728-49-3 ... 1447721-06-3
Matched Mixtures name: … REZOLSTA 800 MG/150 MG FİLM KAPLI TABLET, 30 ADET …
Matched Categories: … Carboxylic Acids ... darunavir and cobicistat ... darunavir and ritonavir ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … Darunavir 600 and 800 mg ... Darunavir Sandoz 75 mg – Filmtabletten ... Darunavir Accord 75 mg Filmtabletten …
Levonorgestrel (LNG) is a synthetic progestogen similar to Progesterone used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices...
Approved
Investigational
Matched Synonyms: … 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one ... 17alpha-Ethynyl-17-hydroxy-18-methylestr-4-en-3-one ... 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one …
Matched Iupac: … (1R,3aS,3bR,9aR,9bS,11aS)-11a-ethyl-1-ethynyl-1-hydroxy-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H ... ,11aH-cyclopenta[a]phenanthren-7-one …
Matched Description: … Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone ... Some of these devices are known as Jaydess, Kyleena, and Mirena. ... [A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as …
Matched Mixtures name: … FEM 7 COMBI 50MCG ... Amethia Lo ... ริเกวิดอน ชนิดเคลือบน้ำตาล 21+7 FE …
Matched Categories: … Combination Contraceptives (with Estrogen and derivatives) ... Genito Urinary System and Sex Hormones ... levonorgestrel and estrogen ... levonorgestrel and estrogen ... levonorgestrel and ethinylestradiol …
Matched Products: … ONE-AND-ONE ... SUSUK KB II TIGA TAHUNAN ... SUSUK KB II TIGA TAHUNAN (CATUR DAKWAH) …
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual,...
Approved
Investigational
Vet approved
Matched Description: … treatment of pre-eclampsia and eclampsia. ... Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. ... A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the …
Matched Salts cas: … 14168-73-1 …
Matched Mixtures name: … Sodium Sulfate, Potassium Sulfate and Magnesium Sulfate ... Sodium Sulfate, Potassium Sulfate and Magnesium Sulfate ... Sodium Sulfate, Potassium Sulfate and Magnesium Sulfate …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Calcium-Regulating Hormones and Agents ... Sulfur Acids
Matched Products: … Spearmint and Menthol scented Natural Epsom Salt …
Izuralimab is under investigation in clinical trial NCT05879185 (A Study of Xmab23104 in People With Sarcoma).
Investigational
Matched Synonyms: … INDUCIBLE T-CELL COSTIMULATORY, ACTIVATION-INDUCIBLE LYMPHOCYTE IMMUNOMEDIATORY MOLECULE, AILIM, CD278)) AND ... DEATH 1) (HUMAN-MUS MUSCULUS MONOCLONAL XMAB23104 SINGLE-CHAIN VARIABLE FRAGMENT VL-LINKER-VH) FUSION PROTEIN
Bazlitoran is under investigation in clinical trial NCT02092909 (Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia).
Investigational
Matched Synonyms: … Antagonist of the endosomal Toll-like receptors (TLRs) 7, 8, and 9 ... ALL-P-AMBO-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOADENYLYL-(3'->5 ... ')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-O-METHYL-P-THIOGUANYLYL …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Calcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland in mammals. It inhibits bone resorption and lowers both serum and urinary calcium concentrations. Human calcitonin is available only in very small quantities but has been used in some studies. The first commercially available preparation in...
Experimental
Matched Synonyms: … Calcitonin Pork ... Calcitonin (pork) ... Calcitonin (pork natural) …
Matched Description: … It inhibits bone resorption and lowers both serum and urinary calcium concentrations. …
Matched Categories: … Sex Hormones and Insulins ... calcitonin (pork natural) …
Pork Collagen is used within MACI® (autologous cultured chondrocytes on porcine collagen membrane) as an autologous cellularized scaffold product indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee with or without bone involvement in adults. It serves as an alternative repair treatment for patients...
Approved
Investigational
Matched Name: … Pork collagen …
Matched Description: … It has been used since 1995 as Carticel and gained biologic license in 1997. ... Pork Collagen is used within MACI® (autologous cultured chondrocytes on porcine collagen membrane) as ... The surgical implantation shows a tolerable safety profile and efficacy up to 4 years, but it is not …
Matched Mixtures name: … Le-Blen Nano Collagen Peptide Serum …
Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow...
Approved
Vet approved
Matched Description: … Oxygen is an element displayed by the symbol O, and atomic number 8. ... Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing ... any disease that impairs the body's ability to take up and use gaseous oxygen. …
Matched Mixtures name: … Carbon Dioxide and Oxygen Mixture, Compressed, Oxidizing, N.O.S. ... Heliox 70/30 ... Helium/Oxygen Mixture 70/30
Matched Products: … OSSIGENO FARMA GAS MEDICAL AND TECHNICAL GASES ... Oxygen/Helium 30/70 ... Oxygen/Nitrogen 30/70
Approved
Experimental
Matched Synonyms: … Echinacea purpurea herb with root ... Echinacea purpurea (l.) moench ... Rudbeckia purpurea l. …
Matched Name: … Echinacea purpurea …
Matched Mixtures name: … Echinacea/golden Seal Cold Formula …
Matched Categories: … Herbs and Natural Products …
Matched Products: … Echinacea Purpurea Root ... Echinacea Root Extract 200mg Capsules ... Adult Echinacea Purpurea …
Investigational
Matched Synonyms: … KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB) VARIANT III (EGFRVIII)) AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON ... , LEU-4)), MONOCLONAL ANTIBODY SINGLE ... RECEPTOR VARIANT III) (HUMAN MONOCLONAL EGFRVIII BISPECIFIC 1 SINGLE-CHAIN VARIABLE FRAGMENT VH1-(GGGGS)3- …
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Approved
Matched Synonyms: … Sodium acid carbonate ... Carbonic acid monosodium salt …
Matched Description: … powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and
Matched Mixtures name: … Juans Santo Remedio PARA LA ACIDEZ ... MILACID® SACHET POR 10ML SABOR MENTA ... ENDOFALK TOZ İÇEREN SAŞE, 72 SAŞE …
Matched Categories: … Antacids and Adsorbents ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Carbonic Acid ... Gastric Acid Lowering Agents …
Matched Products: … Arm and Hammer Baking Soda ... Biflexy 750 ... โซเดียม ไบคาร์บ 7.5
Displaying drugs 351 - 375 of 5907 in total