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Displaying drugs 351 - 375 of 14789 in total

Red pepper

Red pepper allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Non-Standardized Food Allergenic Extract …

Sea scallop

Sea scallop allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Non-Standardized Food Allergenic Extract …

Atlantic mackerel

Atlantic mackerel allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Non-Standardized Food Allergenic Extract …

Atlantic halibut

Atlantic halibut allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Non-Standardized Food Allergenic Extract …

Asfotase alfa

Asfotase alfa is a first-in-class bone-targeted enzyme replacement therapy designed to address the underlying cause of hypophosphatasia (HPP)—deficient alkaline phosphatase (ALP). Hypophosphatasia is almost always fatal when severe skeletal disease is obvious at birth. By replacing deficient ALP, treatment with Asfotase Alfa aims to improve the elevated enzyme substrate levels...
Approved
Investigational
Matched Description: … Asfotase alfa was first approved by Pharmaceuticals and Medicals Devices Agency of Japan (PMDA) on July ... The annual average price of Asfotase Alfa treatment is $285,000. ... a first-in-class bone-targeted enzyme replacement therapy designed to address the underlying cause of …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Oxprenolol

A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.
Approved
Matched Description: … A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and …
Matched Categories: … Beta Blocking Agents, Non-Selective, and Thiazides ... Beta Blocking Agents, Non-Selective ... oxprenolol and thiazides ... Beta Blocking Agents and Thiazides ... oxprenolol and other diuretics …

Prucalopride

Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC...
Approved
Matched Description: … adverse reactions observed due to non-target effects of precedent therapies. ... [A37348] The high selectivity of prucalopride allowed further development as it prevented the cardiac ... A40250] in Canada on December 7, 2011 and by the FDA on December 17, 2018. …
Matched Categories: … Alimentary Tract and Metabolism …

Flortaucipir F-18

Flortaucipir F-18, also known as 18F-T807 and 18F-AV-1451, is a small indole molecule synthesized with a radioactive fluorine isotope. It is used as a marker in positron emission tomography (PET) imaging of patients suspected of having Alzheimer's disease. After crossing the blood-brain barrier, flortaucipir F-18 binds to aggregated tau protein,...
Approved
Investigational
Matched Description: … as to regions containing high levels of melanin, neuromelanin, and iron. ... of having Alzheimer's disease. ... Flortaucipir F-18, also known as 18F-T807 and 18F-AV-1451, is a small indole molecule …
Matched Categories: … Diagnostic Uses of Chemicals …

Romosozumab

Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant to other osteoperosis therapies . Romosozumab prevents bone resorption and induces the formation of bone though it is associated...
Approved
Investigational
Matched Description: … increased risk of cardiac death, heart attack, and stroke in one study[L5921,L5924]. ... women at high risk of fracture and patients who have failed in other treatments or are intolerant to ... Romosozumab prevents bone resorption and induces the formation of bone though it is associated with an …
Matched Categories: … Drugs for Treatment of Bone Diseases ... Amino Acids, Peptides, and Proteins ... Drugs Affecting Bone Structure and Mineralization …

Alectinib

Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK...
Approved
Investigational
Matched Description: … Inhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting ... It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 ... crizotinib, which is associated with the development of resistance. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Dipotassium phosphate

Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.
Approved
Matched Description: … as a source of phosphorus and potassium as well as a buffering agent. ... Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive …
Matched Mixtures name: … Ionosol B and Dextrose …

Asparaginase Escherichia coli

Asparaginase derived from Escherichia coli (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginase from E. coli has clinically shown to exhibit antitumor...
Approved
Investigational
Matched Description: … of PEGylated or non-PEGylated [DB08886] is recommended [A31999]. ... Therapeutic L-asparaginase from _E. coli_ works by depleting the levels of non-essential amino acid, ... L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. …
Matched Categories: … Enzymes and Coenzymes ... Antineoplastic and Immunomodulating Agents …

Enzalutamide

Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line treatment of prostate cancer and remission can be...
Approved
Matched Description: … cancer (CRPC), both metastatic and non-metastatic. ... cancer and remission can be achieved, arising resistance is inevitable, becoming castration-resistant ... [A252667] Second-generation such as enzalutamide is more efficacious due to a higher affinity to AR and …
Matched Categories: … Antiandrogens, non-steroidal ... Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …

Mazindol

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the treatment of Duchenne...
Approved
Investigational
Matched Description: … It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter ... Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and ... Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but …
Matched Categories: … Alimentary Tract and Metabolism ... Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome ... Anorexigenic Agents & Respiratory and CNS Stimulants ... Anorexigenic Agents & Respiratory and Cerebral Stimulants, Miscellaneous …

Etomidate

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Approved
Matched Description: … Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular …
Matched Categories: … Hypnotics and Sedatives …

Digitoxin

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Approved
Investigational
Matched Description: … A cardiac glycoside sometimes used in place of digoxin. ... It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer …

Procaine

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in...
Approved
Investigational
Vet approved
Matched Description: … A local anesthetic of the ester type that has a slow onset and a short duration of action. ... It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Esters of Aminobenzoic Acid ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Letrozole

Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like exemestane and anastrozole, meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole was granted FDA approval on 25 July 1997.
Approved
Investigational
Matched Description: … Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the ... ], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. ... [A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Ozenoxacin

To date, ozenoxacin has been used in trials studying the treatment of impetigo. As of December 11, 2017 the FDA approved Ferrer Internacional S.A.'s Xepi (ozenoxacin 1%) as a topically applied cream indicated for the treatment of impetigo caused by Staphylococccus aureus or Streptococcus pyogenes in adult and pediatric patients...
Approved
Investigational
Matched Description: … and adults in the United States each year, ozenoxacin cream is a novel, non-fluorinated quinolone that ... *Staphylococccus aureus* or *Streptococcus pyogenes* in adult and pediatric patients 2 months of age ... Despite being a common and highly contagious bacerial skin infection that affects millions of children …

Sulthiame

Approved
Matched Categories: … combinations of sulfonamides ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Glatiramer

Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties. Originally, glatiramer acetate was designed as a...
Approved
Investigational
Matched Description: … , and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. ... Glatiramer acetate exhibits several immunomodulatory effects and reduces the relapse rate of relapsing-remitting ... Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Econazole

A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.
Approved
Matched Description: … It is used topically in dermatomycoses also orally and parenterally. …
Matched Categories: … Metabolic Side Effects of Drugs and Substances ... combinations of imidazole derivatives ... Imidazole and Triazole Derivatives ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Iodide I-131

Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of...
Approved
Investigational
Matched Description: … As a result of beta decay, approximately 10% of its energy and radiation dose is via gamma radiation, ... Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid ... Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of …

Xenon-133

Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess pulmonary function.
Approved
Matched Description: … Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess …

Fluoride ion F-18

Sodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added. It contains radioactive fluoride F 18 that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and is administered by intravenous injection. Its primary indication is for bone imaging. Increased deposition around joints can...
Approved
Matched Description: … Increased deposition around joints can occur in arthritis and following trauma and increased deposition ... that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and ... has been noted around fracture sites, in osteomyelitis, fibrous dysplasia, spondylitis tuberculosa, and …
Displaying drugs 351 - 375 of 14789 in total