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Displaying drugs 376 - 400 of 15219 in total

Caffeine

Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to Theophylline and Theobromine.[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in...
Approved
Matched Description: … , by inhalation, or by injection. ... [T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally ... Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory …
Matched Mixtures name: … Pancold A ... Saridon - A ... GRIPAC 4® …

Aluminum chloride

Aluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being the most commonly used Lewis acid....
Approved
Investigational
Matched Description: … It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being ... Aluminum chloride is a chemical compound with the chemical formula AlCl3. ... When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Hemox A …

Melphalan

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Synonyms: … 4-(Bis(2-chloroethyl)amino)-L-phenylalanine …
Matched Iupac: … (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid …
Matched Description: … [L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group ... Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. ... [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. …

Olopatadine

Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating inflammatory and allergic reactions. It is a structural analog of doxepin, which has a minimal anti-allergic activity. Olopatadine works by blocking the effects of histamine, which is a primary inflammatory mediator that causes inflammatory and...
Approved
Matched Description: … Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating ... [L6790] Olopatadine works by blocking the effects of histamine, which is a primary inflammatory mediator ... [A1172] In comparison to other anti-allergenic ophthalmic medications, olopatadine displays a good comfort …
Matched Products: … OLO-A-DAY ... Pataday Twice A Day Relief …

Baloxavir marboxil

Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Description: … by the US approval in October, 2018. ... More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza ... [L4779] It was also approved by the European Commission on January 7, 2021.[L45241] …
Matched Products: … XOFLUZA 20 MG FİLM KAPLI TABLET, 4 ADET …

Delandistrogene moxeparvovec

Delandistrogene moxeparvovec is an adeno-associated virus vector-based gene therapy developed by Sarepta Therapeutics. It was granted accelerated approval by the FDA on June 22, 2023, as the first gene therapy to treat Duchenne Muscular Dystrophy (DMD). DMD is an X-linked genetic disorder characterized by mutations in the dystrophin gene, leading...
Approved
Investigational
Matched Description: … [L47026] DMD is an X-linked genetic disorder characterized by mutations in the dystrophin gene, leading ... to a deficiency in functional dystrophin protein. ... Delandistrogene moxeparvovec is an adeno-associated virus vector-based gene therapy developed by Sarepta …

Ubrogepant

Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor...
Approved
Investigational
Matched Description: … [L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related ... [A189207] Ubrogepant was approved by Health Canada on November 10, 2022. ... advance in migraine headache treatment and may become the new standard of therapy in the treatment of …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Calcitonin Gene-Related Peptide (CGRP) Antagonists ... Calcitonin Gene-Related Peptide Receptor Antagonists …

Dacomitinib

Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on...
Approved
Investigational
Matched Iupac: … (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide …
Matched Description: … [L4810] Some evidence in the literature suggests the therapeutic potential of dacomitinib in the epithelial ... Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone ... [A40009] Dacomitinib was developed by Pfizer Inc and approved by the FDA on September 27, 2018. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Atomoxetine

Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve developmentally inappropriate symptoms associated with ADHD including distractibility, short attention...
Approved
Matched Description: … In particular, increased dopamine in key areas caused by these stimulant medications is associated with ... noradrenergic and dopaminergic pathways plays a critical role in suboptimal executive functioning within ... adults and children as recommended by CADDRA (Canadian ADHD Resource Alliance). …
Matched Products: … STRATTERA 4 MG/ML ORAL ÇÖZELTI ... ATTEX 4 MG/ML ORAL ÇÖZELTİ, 100 ML ... SETİNOX 4 MG/ML ORAL ÇÖZELTİ, 100 ml …

Indacaterol

Indacaterol is a novel, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and chronic obstructive pulmonary disease. It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011. It is marketed in Europe as...
Approved
Matched Description: … It is marketed in Europe as Onbrez and in America as Arcapta Neohaler. ... It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011 ... Indacaterol is also a chiral molecule but only the pure R-enantiomer is dispensed. …

Tezacaftor

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Description: … Alterations in the CFTR gene result in altered production, misfolding, or function of the protein and ... in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, an ion channel ... [L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to …

Permethrin

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
Approved
Investigational
Matched Description: … A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. ... It is a yellow to light orange-brown, low melt-ing solid or viscous liquid. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … A Scabs ... A-LICES LOTION 1%w/w …

Milrinone

Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart...
Approved
Matched Description: … Heart failure is underpinned by numerous physiological changes, including alteration in β-adrenergic ... [A228333] As a PDE-III inhibitor, milrinone results in increased cAMP levels and improves cardiac function ... ® by Sanofi-Aventis US before being discontinued. …
Matched Mixtures name: … Milrinone Lactate in Dextrose …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Milrinone Lactate in Dextrose …

Topiramate

Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy...
Approved
Matched Description: … [A175249] It was initially approved by the FDA in 1996. ... chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. ... [A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel …
Matched Salts cas: … 1246279-00-4 …
Matched Products: … Topamax 15 mg Granulat in Kapseln ... Topamax 25 mg Granulat in Kapseln ... Topamax 50 mg Granulat in Kapseln …

Ginkgo biloba

Ginkgo biloba extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of ginkgo biloba use the standardized extract of Ginkgo biloba (EGb) 761 (EGb761), which...
Approved
Investigational
Nutraceutical
Matched Description: … a German pharmaceutical company in 1964. ... _Ginkgo biloba_ is found in a number of homeopathic and over-the-counter herbal products and dietary ... [A232384] _Ginkgo biloba_ was investigated in preliminary studies for a variety of therapeutic purposes …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Matched Products: … EXTRACTO DE GINKO BILOBA AL 24 % EQUIVALENTE A 9.6 MG DE GLICOSIDOS FLAVONOIDES. …

Agalsidase beta

Agalsidase beta is a recombinant human α-galactosidase A similar to agalsidase alfa. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta.[A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa,...
Approved
Investigational
Matched Description: … a contamination event in 2009. ... While patients generally do not experience a clinically significant difference in outcomes between the ... Agalsidase beta is a recombinant human α-galactosidase A similar to [agalsidase alfa]. …

Palivizumab

Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Synagis is a composite of human (95%) and murine (5%) antibody sequences. The human heavy chain sequence was derived from the constant domains...
Approved
Investigational
Matched Description: … in the A antigenic site of the F protein of respiratory syncytial virus (RSV). ... K104 withJk-4. ... lightchain sequence was derived from the constant domain of Ck and the variable framework regions of the VL gene …

Melatonin

Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about...
Approved
Nutraceutical
Vet approved
Matched Description: … In mammals, melatonin is produced by the pineal gland. ... In particular, melatonin regulates the sleep-wake cycle by chemically causing drowsiness and lowering ... Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Mellozzan 4 mg Tabletten …

Leuprolide

Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to...
Approved
Investigational
Matched Iupac: … hydroxyphenyl)propanamido]-4-methylpentanamido]-4-methylpentanamido]pentanoyl]-N-ethylpyrrolidine-2-carboxamide ... -1-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-4- ... )-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4- …
Matched Description: … tradename Lupron™ by Abbvie Endocrine Inc. ... [A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the ... Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). …
Matched Products: … LUPRON ® DEPOT 11.25 MG POLVO LIOFILIOZADO PARA RECONSTITUIR A SUSPENSIÓN INYECTABLE …

Capsaicin

Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent...
Approved
Matched Iupac: … (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide …
Matched Description: … Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, ... Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical ... and patch preparations of various strengths; however, it may also be found in some dietary supplements …
Matched Mixtures name: … Tianhe Gutong Tiegao (in Polyisobutylene Carrier) ... 1st Medxpatch With Lidocaine 4% ... 1st Medxpatch With Lidocaine 4%-rx …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Matched Products: … Antiphlogistine Rub A-535 Capsaicin Gel ... Antiphlogistine Rub A-535 Capsaicin Liquid …

Methylphenidate

Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally...
Approved
Investigational
Matched Description: … gene (DAT1), the D4 receptor gene (DRD-4), and/or the D2 receptor gene that may be at least partly overcome ... by the dopaminergic effects of methylphenidate, suggesting a possible mode of action. ... [A631] OROS is comprised of an osmotically active trilayer core surrounded by a semipermeable membrane …
Matched Salts cas: … 23655-65-4 …

Velaglucerase alfa

Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease.
Approved
Investigational
Matched Description: … Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. ... Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of ... Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease. …

Propofol

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness,...
Approved
Investigational
Vet approved
Matched Description: … administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a ... Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory …
Matched Products: … FRESOFOL MCT/LCT EMULSION FOR INJECTION OR INFUSION IN PRE-FILLED SYRINGE 2% ... Propofol "Fresenius" 1 % mit MCT Emulsion zur Injektion oder Infusion in einer Fertigspritze ... Propofol "Fresenius" 2 % mit MCT Emulsion zur Injektion oder Infusion in einer Fertigspritze …

Talimogene laherparepvec

Talimogene laherparepvec is an oncolytic treatment used in local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with recurrent melanoma. It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. It specifically replicates within...
Approved
Experimental
Investigational
Matched Description: … It was approved by the FDA in 2015 under the market name Imlygic. ... It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage ... subcutaneous, and nodal lesions in patients with recurrent melanoma. …
Matched Categories: … Antineoplastic cell and gene therapy …

Migalastat

Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycosphingolipid substrate that, when deficient in patients with Fabry disease, builds up in the blood vessels, the kidneys,...
Approved
Investigational
Matched Description: … Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes ... [L47036,L47057,L4274,L4278] In these patients, migalastat works by stabilizing the body’s dysfunctional ... a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). …
Matched Categories: … Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones …
Displaying drugs 376 - 400 of 15219 in total