Displaying drugs 376 - 400 of 8033 in total
Acarbose
Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are responsible for the metabolism of complex starches and...
Approved
Investigational
Matched Description: … [L31633,A37868] By inhibiting the activity of these enzymes, acarbose limits the absorption of dietary ... breakdown of complex carbohydrates in the intestines. ... Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the …
Alcaftadine
Alcaftadine is a H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. This drug was approved in July 2010.
Approved
Matched Description: … Alcaftadine is a H1 histamine receptor antagonist indicated for the prevention of itching associated …
Sulfur hexafluoride
Sulfur hexafluoride is an ultrasound contrast agent indicated for use
•in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms
•in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric...
Approved
Matched Description: … the liver for characterization of focal liver lesions in adult and pediatric patients ... for use
•in echocardiography to opacify the left ventricular chamber and to improve the delineation of ... ventricular endocardial border in adult patients with suboptimal echocardiograms
•in ultrasonography of …
Betibeglogene autotemcel
Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (βA-T87Q-globin) to hematopoietic stem cells in order to treat β-thalassemia. β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a significant decrease in the production of β-globin. This affects...
Approved
Investigational
Matched Description: … transfusions are required for survival and the prevention of serious complications. ... Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene ... This affects hemoglobin levels, and in patients with severe forms of this disease, long-term red cell …
Lotilaner
Lotilaner is an ectoparasiticide that is a member of the isoxazoline family of compounds. Lotilaner has largely been used for veterinary uses as an antiparasitic agent to treat flea and tick infestations in animals.[A260746, L47556] Lotilaner consists of two enantiomers: the S-enantiomer is active in vivo, while the R-enantiomer is...
Approved
Vet approved
Matched Description: … Lotilaner is an ectoparasiticide that is a member of the isoxazoline family of compounds. ... The active ingredient found in drug products of lotilaner is the S-enantiomer. ... [A260746, L47556] Lotilaner consists of two enantiomers: the S-enantiomer is active _in vivo_, while …
Chromic chloride
Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Approved
Alpelisib
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target...
Approved
Investigational
Matched Description: … [L6652] In April 2022, the FDA granted the use of alpelisib in the treatment of PIK3CA-Related Overgrowth ... It works by selectively inhibiting class I PI3K p110α [A179203], which is the catalytic subunit of PI3K ... Alpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human …
Carfilzomib
Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.
Approved
Investigational
Matched Description: … Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. ... FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple …
Iodide I-131
Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of...
Approved
Investigational
Matched Description: … this mechanism for localization of drug to the site of malignancy. ... As a result of beta decay, approximately 10% of its energy and radiation dose is via gamma radiation, ... Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid …
Ixazomib
Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to...
Approved
Investigational
Matched Description: … myeloma growth and prevention of bone loss. ... similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of …
Ceftobiprole medocaril
Ceftobiprole medocaril is a prodrug of ceftobiprole, a fifth-generation semisynthetic cephalosporin antibacterial. Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of Staphylcoccus aureus (methicillin-resistant Staphylococcus aureus; MRSA).
The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion...
Approved
Experimental
Investigational
Matched Description: … Ceftobiprole medocaril is a prodrug of [ceftobiprole], a fifth-generation semisynthetic cephalosporin ... activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of ... medocaril in February 2010, recommending the refusal of its marketing authorization in the European …
Ibrexafungerp
Ibrexafungerp, also known as SCY-078 or MK-3118, is a novel enfumafungin derivative oral triterpene antifungal approved for the treatment of vulvovaginal candidiasis (VVC), also known as a vaginal yeast infection.[A235384,L34349] It was developed out of a need to treat fungal infections that may have become resistant to echinocandins or azole...
Approved
Investigational
Matched Description: … or MK-3118, is a novel enfumafungin derivative oral triterpene antifungal approved for the treatment of ... [A235384,L34349] It was developed out of a need to treat fungal infections that may have become resistant ... ibrexafungerp targets the fungal β-1,3-glucan synthase, which is not present in humans, limiting the chance of …
Eplontersen
Eplontersen is a transthyretin-directed antisense oligonucleotide with 3 covalently linked e N-acetyl galactosamine residues for hepatic delivery. It was previously investigated as a potential treatment for hereditary transthyretin-mediated amyloidosis. Hereditary transthyretin-mediated amyloidosis is caused primarily by pathogenic variants of the TTR gene, leading to the formation and thus accumulation of...
Approved
Investigational
Matched Description: … adult polyneuropathy of hereditary transthyretin-mediated amyloidosis. ... [A262975] Hereditary transthyretin-mediated amyloidosis is caused primarily by pathogenic variants of ... On December 21, 2023, the FDA approved eplontersen under the brand name WAINUA for the treatment of …
Vayarin
Vayarin is a prescription medical food for the clinical dietary management of certain lipid imbalances blamed to be associated with attention deficit hyperactivity disorder (ADHD) in children. Vayarin contains Lipirinen, a proprietary composition containing phosphatidylserine-omega 3, EPA (eicosapentaenoic acid), and docosahexaenoic acid (DHA) [L1500, L1510]. Vayarin is currently available only...
Approved
Investigational
Matched Description: … A slow response time of 12 weeks is an impediment to successful management of ADHD as only 41.6% of subjects ... Cost of the drug and patient aversion to the taste of Vayarin were significant reasons for therapy failure ... Approximately 60% of the users who completed 12 weeks of therapy reported subjective benefits from treatment …
Methylene blue
Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered...
Approved
Investigational
Matched Description: … The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult ... The drug is of potential interest for the treatment of patients with Alzheimer's disease. ... Aberdeen and TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Venetoclax
Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Description: … Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic ... Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed ... Venetoclax was developed through reverse engineering of the BCL-2 protein family inhibitor, navitoclax …
Coral snake (micrurus fulvius) immune globulin antivenin (equine)
North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites. It is intravenously administered so that the antivenin binds to and neutralizes coral snake venom.
The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins...
Approved
Experimental
Matched Description: … North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of ... The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins obtained by …
Lanadelumab
Lanadelumab, also known as DX-2930, is a human IgG1 monoclonal antibody designed for subcutaneous self-injection. It is a fully human immunoglobulin, k-light-chain made in recombinant Chinese Hamster Ovary cells. It has been granted priority review, breakthrough therapy, and orphan drug designations for rare diseases based on the results of clinical...
Approved
Investigational
Matched Description: … priority review, breakthrough therapy, and orphan drug designations for rare diseases based on the results of …
Rivaroxaban
Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15...
Approved
Matched Description: … Unlike warfarin, routine lab monitoring of INR is not necessary. ... However there is no antidote available in the event of a major bleed. …
Dalteparin
Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the range of 2000-9000....
Approved
Matched Description: … 5000 and about 90% of the material within the range of 2000-9000. ... It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of ... heparin of porcine intestinal mucosa origin, is an anticoagulant. …
Prednisolone phosphate
Prednisolone phosphate is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone phosphate was granted FDA Approval on 19 December 1973.
Approved
Vet approved
Semaglutide
Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include Exenatide and Liraglutide. Semaglutide was developed by Novo Nordisk and approved by the FDA for subcutaneous injection...
Approved
Investigational
Matched Description: … The use of salt forms of semaglutide, including semaglutide sodium and semaglutide acetate, has not been ... [A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. ... [L34485] The use of semaglutide in weight management is also approved by Health Canada [L39347] and the …
Levoketoconazole
Cushing's syndrome (CS) is underpinned by chronic hypercortisolism leading to multisystem morbidity, including effects on the cardiovascular and endocrine systems, metabolic syndrome with accompanying changes in body composition, neuropsychiatric effects, changes in blood pressure and chemistry, and opportunistic infections.[A244078, A244083] Ketoconazole has been used both on- and off-label to treat...
Approved
Investigational
Matched Description: … [A244083] Levoketoconazole is one of two enantiomers present in racemic [ketoconazole]. ... It possesses most of the inhibitory effect towards steroidogenic enzymes, making it an attractive candidate …
Ferumoxytol
Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) .
It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral...
Approved
Investigational
Matched Description: … is an intravenously administered iron preparation indicated in the EU and the US for the treatment of ... It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate …
Fostemsavir
Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in...
Approved
Investigational
Matched Description: … [L14867] The discovery of gp120 as a potential target of interest in the treatment of HIV-1 infection ... Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. ... orthogonal therapies) for the treatment of HIV-1 patients with resistant infections. …
Displaying drugs 376 - 400 of 8033 in total