Displaying drugs 4026 - 4050 of 8039 in total
Etizolam
Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983...
Experimental
Itopride
Itopride is a dopamine D2 antagonist with acetylcholinesterase inhibitory actions.
Investigational
Amrubicin
Amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of small cell lung cancer. Pharmion licensed the rights to Amrubicin in November 2006. In 2002, Amrubicin was approved and launched for sale in Japan based on Phase 2 efficacy data in both SCLC and NSCLC. Since January...
Investigational
Matched Description: … Amrubicin is a third-generation synthetic anthracycline currently in development for the treatment of ... oncology, which licensed Japanese marketing rights from Dainippon Sumitomo, the original developer of …
Isoflavone
Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa . Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content is 1-2 mg/gram . The main soy isoflavones are mostly...
Experimental
Matched Description: … of soy products associated with a reduced incidences of coronary heart disease, atherosclerosis, type ... Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important ... Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content …
Camazepam
Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam. Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal muscle relaxant properties. However, unlike other benzodiapeines camazepam is predominantly anxiolytic and is relatively weak as an anticonvulsant, hypnotic and...
Experimental
Illicit
Matched Description: … Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam ... However, impairment of cognition and disrupted sleep patterns will occur at doses higher than 40mg of …
Polaprezinc
Polaprezinc is a chelated form of zinc and L-carnosine. It is a zinc-related medicine approved for the first time in Japan, which has been clinically used to treat gastric ulcers [L1307, L1308]. It was determined that polaprezinc may be effective in pressure ulcer treatment . A study in 2013 showed...
Experimental
Matched Description: … Polaprezinc is a chelated form of zinc and L-carnosine. ... A study in 2013 showed that CO-administration of polaprezinc may be effective against small intestine …
Azimilide
Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States.
Investigational
Matched Description: … Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of …
GTS-21
GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition...
Investigational
Matched Description: … Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the ... acquisition of Osprey Pharmaceutical Company in April 2006. …
Dexloxiglumide
Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist in phase III testing by Rottapharm in Europe only, as U.S. trials have been discontinued. As the D-isomer of loxiglumide, it retains all pharmacological properties of loxiglumide but is more potent.
Investigational
Matched Description: … As the D-isomer of loxiglumide, it retains all pharmacological properties of loxiglumide but is more …
Cethromycin
Cethromycin is a 3-keto (ketolide) derivative of erythromycin A with an 11,12-carbamate group and an O-6-linked aromatic ring system. Cethromycin represents a joint development effort by Abbott Laboratories, Taisho Pharmaceuticals, and Advanced Life Sciences, intended to be marketed under the trade name Restanza for the treatment of community-acquired pneumonia.[L14006, A203369]...
Investigational
Matched Description: … Cethromycin is a 3-keto (ketolide) derivative of erythromycin A with an 11,12-carbamate group and an ... and Advanced Life Sciences, intended to be marketed under the trade name Restanza for the treatment of ... L13988] It has also been investigated, by itself or together with [zoliflodacin], for the treatment of …
Brasofensine
Brasofensine is an orally administered dopamine reuptake inhibitor being developed for the treatment of Parkinson's Disease. Phase I/II trials for brasofensine have been completed in the U.K. In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230.
Investigational
Matched Description: … Brasofensine is an orally administered dopamine reuptake inhibitor being developed for the treatment of ... In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230 …
Triazavirin
Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain.[A191709,A191625,A191916] It appears that Triazavirin has shown promise in reducing influenza disease severity and associated complications. Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating...
Experimental
Tagatose
Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of the calories. It is approved as a food additive as a low calorie sweetener. Additionally,...
Investigational
Matched Description: … commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of ... Additionally, it is under investigation by Spherix for the treatment of obesity and type II diabetes. …
Queuine
Queuine is a derivative of 7-Deazaguanine. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, and goats. Humans salvage and recover queuine from either...
Experimental
Nutraceutical
Matched Description: … Queuine is a derivative of [7-Deazaguanine]. ... Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, ... , including humans, transform queuine to queuosine by placing it in the wobble position (anticodon) of …
Arginine
An essential amino acid that is physiologically active in the L-form.
Investigational
Nutraceutical
Rheinanthrone
Rheinanthrone is the active metabolite of senna glycoside DB11365 known for its laxative effect . It is commonly produced by plants of the Rheum species .
Experimental
Matched Description: … It is commonly produced by plants of the Rheum species [L772]. ... Rheinanthrone is the active metabolite of senna glycoside [DB11365] known for its laxative effect [A19235 …
Perospirone
Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. Dainippon Sumitomo Pharma developed perospirone in Japan in 2001 for the treatment of acute schizophrenia and bipolar mania as...
Experimental
Matched Description: … Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes ... Dainippon Sumitomo Pharma developed perospirone in Japan in 2001 for the treatment of acute schizophrenia …
Flupirtine
Flupirtine is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe. It is not approved for use in the U.S. or Canada, but is currently in phase II trials for the treatment of fibromyalgia.
Investigational
Matched Description: … It was approved for the treatment of pain in 1984 in Europe. ... is not approved for use in the U.S. or Canada, but is currently in phase II trials for the treatment of …
Leronlimab
Leronlimab, or PRO-140, is a human monoclonal antibody developed by CytoDyn. It was first described in the literature in 2001. This antibody binds to CCR5, which may be useful in treating HIV, cancers, and severely ill COVID-19 patients.[A192846,A192858,L12684]
Investigational
Lobeglitazone
Lobeglitazone is an antidiabetic medication from the thiazolidinedione class of drugs. It primarily functions as an insulin sensitizer by binding and activating Peroxisome Proliferator-Activated Receptors (PPAR) gamma within fat cells. By activating PPAR-gamma and promoting the binding of insulin at fat cells, lobeglitazone thereby has been shown to reduce blood...
Experimental
Matched Description: … Lobeglitazone is an antidiabetic medication from the thiazolidinedione class of drugs. ... By activating PPAR-gamma and promoting the binding of insulin at fat cells, lobeglitazone thereby has ... Lobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being …
Bentiromide
Bentiromide is a dipeptide that is used in the bentiromide test, which is a screening test for evaluating pancreatic exocrine function and monitoring the adequacy of supplemental pancreatic therapy. It is typically administered orally. Cases of headache and gastrointestinal disturbances have been reported with the use of bentiromide. Bentiromide is...
Investigational
Withdrawn
Matched Description: … Cases of headache and gastrointestinal disturbances have been reported with the use of bentiromide. ... , which is a screening test for evaluating pancreatic exocrine function and monitoring the adequacy of …
Mometasone
Mometasone is a corticosteroid not currently used in medical products. Mometasone furoate however, is still in use.
Experimental
Bicifadine
Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain.
Investigational
Matched Description: … It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with ... to have potent analgesic activity in vivo and was chosen for further development for the treatment of …
Umifenovir
Umifenovir is an indole-based, hydrophobic, dual-acting direct antiviral/host-targeting agent used for the treatment and prophylaxis of influenza and other respiratory infections. It has been in use in Russia for approximately 25 years and in China since 2006. Its invention is credited to a collaboration between Russian scientists from several research...
Investigational
Matched Description: … hydrophobic, dual-acting direct antiviral/host-targeting agent used for the treatment and prophylaxis of ... collaboration between Russian scientists from several research institutes 40-50 years ago, and reports of ... effects through multiple pathways has resulted in considerable investigation into its use for a variety of …
Displaying drugs 4026 - 4050 of 8039 in total