Displaying drugs 4151 - 4175 of 8090 in total
Bambuterol
Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.
Investigational
Matched Description: … It is a prodrug of terbutaline. ... Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. …
Indium In-111 satumomab pendetide
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
Experimental
Withdrawn
Josamycin
A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
Investigational
Matched Description: … The drug has antimicrobial activity against a wide spectrum of pathogens. …
Virginiamycin M1
Pristinamycin IIA is a macrolide antibiotic, a member of the streptogramin A group of antibiotics, and one component of pristinamycin. It is produced by Streptomyces graminofaciens and other bacteria.
Experimental
Matched Description: … Pristinamycin IIA is a macrolide antibiotic, a member of the streptogramin A group of antibiotics, and ... one component of pristinamycin. …
Camptothecin
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Experimental
Matched Description: … Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. ... Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata …
Isatoribine
Isatoribine is a selective agonist of TLR7.
Investigational
Matched Description: … Isatoribine is a selective agonist of TLR7. …
Olcegepant
Boehringer Ingelheim Pharmaceuticals’ olcegepant (BIBN 4096) is a selective Calcitonin Gene-Related Peptide (CGRP) antagonist, a new class of drugs in development for the treatment of acute migraine attacks. Olcegepant is undergoing phase II trials in Europe and the US, with preliminary results suggesting that CGRP antagonists may represent a potential...
Investigational
Matched Description: … drugs in development for the treatment of acute migraine attacks. ... olcegepant (BIBN 4096) is a selective Calcitonin Gene-Related Peptide (CGRP) antagonist, a new class of ... preliminary results suggesting that CGRP antagonists may represent a potential new approach to the treatment of …
Metralindole
Metralindole, also known as Inkazan, is similar in structure and pharmacology to pirlindole. It functions as a reversible inhibitor of monoamine oxidase A. In Russia, this drug was investigated for potential antidepressant activity.
Experimental
Matched Description: … It functions as a reversible inhibitor of monoamine oxidase A. …
Loxicodegol
Loxicodegol was developed by Nektar Therapeutics as an opioid analgesic with low abuse potential for the treatment of chronic pain . The lack of abuse potential is believed to be due to the drug's slow rate of entry into brain, a unique characteristic compared to others in the opioid class...
Investigational
Matched Description: … The lack of abuse potential is believed to be due to the drug's slow rate of entry into brain, a unique ... of chronic lower back pain [L3263] ... developed by Nektar Therapeutics as an opioid analgesic with low abuse potential for the treatment of …
Elacridar
Elacridar (GW120918) is an oral bioenhancer that targets multiple drug resistance in tumors. In many cases, the appearance of multidrug resistance in cancer is due to a change in expression of protein inhibitors. As of August 2007 elacridar was not listed on GSK's product pipeline. Development is assumed to have...
Investigational
Matched Description: … In many cases, the appearance of multidrug resistance in cancer is due to a change in expression of protein ... As of August 2007 elacridar was not listed on GSK's product pipeline. …
AZD3409
AZD3409 is a farnesyl-transferase inhibitor (FAR) indicated for the treatment of solid tumors. Phase I trials were initiated January 2003, and were ongoing as of February 2004. As of February 2007 the development of AZD3409 had been discontinued.
Investigational
Matched Description: … As of February 2007 the development of AZD3409 had been discontinued. ... Phase I trials were initiated January 2003, and were ongoing as of February 2004. ... AZD3409 is a farnesyl-transferase inhibitor (FAR) indicated for the treatment of solid tumors. …
PS386113
PS386113 is a small molecule drug candidate under investigation for the treatment of inflammatory disorders. It is being developed by Schering-Plough and Pharmacopeia. Little information has been released about PS386113.
Investigational
Matched Description: … PS386113 is a small molecule drug candidate under investigation for the treatment of inflammatory disorders …
Mepiprazole
Mepiprazole is a minor tranquilizer with a phenylpiperazine structure. It is a pyrazolyl-alkyl-piperazine derivative. Mepiprazole mediates a weak inhibitory action on the uptake of 5-HT on hypothalamic neurons .
Mepiprazole is marketed in Spain for the treatment of anxiety neuroses.
It acts as a 5-HT2A and α1-adrenergic receptor antagonist, and...
Experimental
Matched Description: … Mepiprazole is marketed in Spain for the treatment of anxiety neuroses. ... Mepiprazole mediates a weak inhibitory action on the uptake of 5-HT on hypothalamic neurons [A7816]. ... Clinical studies of mepiprazole including patients with irritable bowel syndrome (IBS) were conducted …
Aptazapine
Aptazapine (CGS-7525A) was a tetracyclic antidepressant developed in the 1980s. Aptazapine had noradrenergic and specific serotonergic activity. It antagonised α2 adrenergic receptors approximately 10 times more effectively than mianserin, antagonised 5-HT2 receptors, agonised H1 receptors, and did not affect reuptake of serotonin or norepinephrine. Although Aptazapine reached clinical trials, it...
Experimental
Matched Description: … effectively than mianserin, antagonised 5-HT2 receptors, agonised H1 receptors, and did not affect reuptake of …
Potassium bitartrate
Potassium bitartate, also referred to as potassium acid tartrate or cream of tartar, is the potassium acid salt of l-( + )-tartaric acid. It is obtained as a byproduct of wine manufacture during the fermentation process. Approved by the FDA as a direct food substance, potassium bitartrate is used as...
Experimental
Matched Description: … acid salt of l-( + )-tartaric acid. ... It is obtained as a byproduct of wine manufacture during the fermentation process. ... Potassium bitartate, also referred to as potassium acid tartrate or cream of tartar, is the potassium …
Pyridoxal
The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem]
Experimental
Nutraceutical
Matched Description: … The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme ... for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic …
Vapreotide
Vapreotide is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer.
Experimental
Investigational
Matched Description: … It was being studied for the treatment of cancer. …
Methyclothiazide
A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Withdrawn
Matched Description: … A thiazide diuretic with properties similar to those of hydrochlorothiazide. …
Marimastat
Used in the treatment of cancer, Marmiastat is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.
Investigational
Matched Description: … As an angiogenesis inhibitor it limits the growth and production of blood vessels. ... Used in the treatment of cancer, Marmiastat is an angiogenesis and metastasis inhibitor. …
Lefradafiban
Lefradafiban is an oral platelet glycoprotein IIb/IIIa receptor antagonist being investigated in the treatment of angina.
Investigational
Matched Description: … Lefradafiban is an oral platelet glycoprotein IIb/IIIa receptor antagonist being investigated in the treatment of …
Ramoplanin
Ramoplanin is a novel glycolipodepsipeptide antibiotic under development for the treatment of CDAD.
Investigational
Matched Description: … Ramoplanin is a novel glycolipodepsipeptide antibiotic under development for the treatment of CDAD. …
Beraprost
Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.
Investigational
Matched Description: … Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary …
NRP409
NRP409 is a triiodothyronine (T3) hormone, being investigated by New River Pharmaceuticals as a treatment for patients with primary hypothyroidism.
Investigational
Setiptiline
Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). In Japan, the company Mochida started its commercialization for the treatment of depression started in 1989.
Experimental
Matched Description: … In Japan, the company Mochida started its commercialization for the treatment of depression started in …
Displaying drugs 4151 - 4175 of 8090 in total