Displaying drugs 4351 - 4375 of 8179 in total
Verubecestat
Verubecestat is under investigation for the treatment of Alzheimer's Disease, Prodromal Alzheimer's disease, and Amnestic Mild Cognitive Impairment.
Verubecestat is Merck’s investigational oral β-site amyloid precursor protein cleaving enzyme (BACE1 or β secretase) inhibitor. In July 2013, Merck announced positive results for Phase Ib trials of Verubecestat. In the study,...
Investigational
Matched Description: … and sustained reduction in the levels of Ab40, a measure of BACE1 activity, in CSF from baseline of ... In the study, administration of Verubecestat at doses of 12, 40 and 60 mg resulted in a dose-dependent ... In July 2013, Merck announced positive results for Phase Ib trials of Verubecestat. …
PI-103
PI-103 is an inhibitor of p110α of class I PI3K.
Investigational
Matched Description: … PI-103 is an inhibitor of p110α of class I PI3K.[A253092] …
Entolimod
Entolimod has been used in trials studying the treatment of Mucositis, Tongue Cancer, Colorectal Cancer, Stage IVA Verrucous Carcinoma of the Larynx, and Stage IVB Verrucous Carcinoma of the Larynx, among others.
Investigational
Matched Description: … , Stage IVA Verrucous Carcinoma of the Larynx, and Stage IVB Verrucous Carcinoma of the Larynx, among ... Entolimod has been used in trials studying the treatment of Mucositis, Tongue Cancer, Colorectal Cancer …
MUL001
MUL001 is live attenuated strain of Salmonella typhimurium being investigated for the treatment of schwannomas.
Investigational
Matched Description: … MUL001 is live attenuated strain of _Salmonella typhimurium_ being investigated for the treatment of …
Ferric pyrophosphate
Ferric pyrophosphate is an iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate. It presents an increasing interest as this insoluble...
Experimental
Matched Description: … interactions of iron in plasma. ... side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of …
Propanidid
An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918)
Experimental
Matched Description: … anesthesia of short duration. ... An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of …
Efavaleukin alfa
Efavaleukin alfa is a fusion protein consisting of interleukin mutein fused to the C-terminus of an immunoglobulin G Fc domain by way of a G4S linker. It is under investigation in clinical trial NCT03422627 (Safety and Efficacy of AMG 592 in Subjects With Steroid Refractory Chronic Graft Versus Host Disease).
Investigational
Matched Description: … G Fc domain by way of a G4S linker. ... Efavaleukin alfa is a fusion protein consisting of interleukin mutein fused to the C-terminus of an immunoglobulin ... It is under investigation in clinical trial NCT03422627 (Safety and Efficacy of AMG 592 in Subjects With …
ARX201
ARX201 (PEG-ahGH) is a recombinant form of human growth hormone that has been modified using Ambrx’s patented ReCODE™ technology to achieve precise spatial positioning of the site of polyethylene glycol (PEG) attachment to human growth hormone, by biosynthetic incorporation of a chemically unique amino acid (ahGH). ARX201 has improved pharmacological...
Investigational
Matched Description: … patented ReCODE™ technology to achieve precise spatial positioning of the site of polyethylene glycol ... ARX201 (PEG-ahGH) is a recombinant form of human growth hormone that has been modified using Ambrx’s ... (PEG) attachment to human growth hormone, by biosynthetic incorporation of a chemically unique amino …
NTx-265
NTx-265 is a combination of two currently marketed large molecules designed to stimulate the growth and differentiation of neural stem cells in adults who have suffered a stroke – the second leading cause of death worldwide. In May 2006, biotechnology company Stem Cell Therapeutics started a Phase IIa study of...
Investigational
Matched Description: … of death worldwide. ... NTx-265 is a combination of two currently marketed large molecules designed to stimulate the growth and ... In May 2006, biotechnology company Stem Cell Therapeutics started a Phase IIa study of NTx-265. …
Tallimustine
Tallimustine, a benzoyl mustard derivative of distamycin A, is an alkylating agent that binds to the minor groove of DNA.[A182036,A182039] It's association with severe myelotoxicity lead to the end of its development in favour of α-halogenoacrylamide derivatives such as brostallicin, which have a favourable cytotoxicity/myelotoxicity ratio.[A182039,A182045] Newer generations of DNA...
Experimental
Matched Description: … minor groove of DNA. ... Tallimustine, a benzoyl mustard derivative of distamycin A, is an alkylating agent that binds to the ... [A182036,A182039] It's association with severe myelotoxicity lead to the end of its development in favour …
APR-548
APR-548 is an analog of eprenetapopt and a reactivator of mutant p53.
Investigational
Matched Description: … APR-548 is an analog of [eprenetapopt] and a reactivator of mutant p53. …
Cefovecin
Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner compliance with dosing for the animal. It is used for the treatment of skin infections caused by Pasturella multocida in...
Experimental
Vet approved
Matched Description: … The presence of low concentrations of antibiotics is related to the development of microbial resistance ... Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. ... The advantage of using injectable antibiotics is not missing a dose that can allow partially resistant …
Stannsoporfin
Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.
Investigational
Matched Description: … WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing ... Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of …
Choline alfoscerate
A component of phosphatidylcholines (lecithins), in which the two hydroxy groups of glycerol are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes and other macromolecules. [PubChem]
Experimental
Investigational
Matched Description: … A component of phosphatidylcholines (lecithins), in which the two hydroxy groups of glycerol are esterified ... (From Stedman, 26th ed) It counteracts the effects of urea on enzymes and other macromolecules. …
Eritoran
Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Investigational
Matched Description: … Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). ... It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis. …
Elezanumab
Elezanumab is under investigation in clinical trial NCT03737812 (A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis).
Investigational
Matched Description: … Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis). ... Elezanumab is under investigation in clinical trial NCT03737812 (A Study to Assess the Safety and Efficacy of …
MK-0773
MK-0773 is under investigation in clinical trial NCT00529659 (A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(mk-0773-005)).
Investigational
Matched Description: … MK-0773 is under investigation in clinical trial NCT00529659 (A Study of the Safety and Efficacy of MK ... -0773 in Women With Sarcopenia (Loss of Muscle Mass)(mk-0773-005)). …
Praliciguat
Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)).
Investigational
Matched Description: … Praliciguat is under investigation in clinical trial NCT03254485 (A Study of the Effect of IW-1973 on ... the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (Hfpef)). …
Hyperforin
Hyperforin is a phytochemical generated by the plants of the Hypericum family. One of the most important members of this family, due to its medical properties, is Hypericum perforatum, also known as St John's wort.
Nutraceutical
Matched Description: … One of the most important members of this family, due to its medical properties, is _Hypericum perforatum ... Hyperforin is a phytochemical generated by the plants of the Hypericum family. …
Isoquercetin
Isoquercetin has been used in trials studying the treatment of Kidney Cancer, Renal cell carcinoma, Advanced Renal Cell Carcinoma, Thromboembolism of Vein in Pancreatic Cancer, and Thromboembolism of Vein VTE in Colorectal Cancer, among others.
Investigational
Matched Description: … Renal Cell Carcinoma, Thromboembolism of Vein in Pancreatic Cancer, and Thromboembolism of Vein VTE ... Isoquercetin has been used in trials studying the treatment of Kidney Cancer, Renal cell carcinoma, Advanced …
Methylselenocysteine
Methylselenocysteine has been used in trials studying the prevention of Prostate Carcinoma and No Evidence of Disease.
Investigational
Matched Description: … of Disease. ... Methylselenocysteine has been used in trials studying the prevention of Prostate Carcinoma and No Evidence …
Demcizumab
Demcizumab is under investigation for the treatment of Nonsquamous Nonsmall Cell Neoplasm of Lung.
Investigational
Matched Description: … Demcizumab is under investigation for the treatment of Nonsquamous Nonsmall Cell Neoplasm of Lung. …
Coenzyme A
Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of...
Investigational
Nutraceutical
Matched Description: … enzymes use it, or a thioester form of it, as a substrate. ... fatty acids, and the oxidation of pyruvate in the citric acid cycle. ... It is used as a supplement for the hypothetical treatment of acne. …
Fenspiride
Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as...
Experimental
Matched Description: … It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT ... Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory ... rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of …
GSK-945237
GSK-945237 is under investigation in clinical trial NCT01039610 (A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology Safety Parameters; and the Effects of GSK945237...
Investigational
Matched Description: … a Single Oral Dose and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology ... Safety Parameters; and the Effects of GSK945237 and Moxifloxacin on QTc.). ... Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of …
Displaying drugs 4351 - 4375 of 8179 in total