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Displaying drugs 426 - 450 of 11832 in total

Cipaglucosidase alfa

Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated for the treatment of patients with Pompe disease, a rare inherited metabolic disorder characterized by a deficiency in GAA. Other types of enzyme replacement therapy for the treatment of Pompe disease include alglucosidase alfa and avalglucosidase alfa. Cipaglucosidase...
Approved
Investigational
Matched Description: … skeletal muscle, one of the main affected tissues in Pompe disease. ... phosphate (M6P) N-glycans that bind to the cation-independent mannose-6-phosphate receptor (CI-MPR) in ... [A232955, A232960] In December 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP …

CVac

Approved
Investigational

Ceftazidime

Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis,...
Approved
Matched Description: … Ceftazidime was approved by the FDA on July 19, 1985, and is currently available either alone or in ... antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in …

Cyclizine

A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Approved
Matched Description: … antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in …

Crotamiton

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Erythrityl tetranitrate

A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)
Approved
Experimental
Investigational
Matched Categories: … Vasodilators Used in Cardiac Diseases …

Carboxin

A systemic agricultural fungicide and seed treatment agent.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Pentoxifylline

Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.[A226415, L30300] Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated for its possible...
Approved
Investigational
Matched Description: … originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in ... patients with peripheral arterial disease, PTX has been investigated for its possible use in diverse ... [A226608] Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Bentonite

Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cetalkonium

Cetalkonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in different types of formulations. It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and fungi. Cetalkonium is approved by the FDA for its use...
Approved
Matched Description: … C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in ... [L2737] By Health Canada, it is also approved for its use in over-the-counter products.[L1113] ... [L2137] Cetalkonium is approved by the FDA for its use in over-the-counter products as a skin protectant …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Bromothalonil

Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products. It is also a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy . In 2005,...
Approved
Experimental
Matched Description: … In 2005, MDBGN was named in the top 15 most frequently positive allergens identified in patch tests by ... also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in ... It is also a known allergen and dermatological irritant that has been banned in many EU countries due …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Simethicone

Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed. Simethicone has been in use since the 1940s but was granted FDA approval in 1952.
Approved
Matched Description: … [A228308] Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952 …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Methylcellulose

Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3,...
Approved
Matched Description: … Methyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Apalutamide

Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Description: … In mice bearing human CRPC xenograft models, apalutamide treatment produced tumor regressions in a dose-dependent ... Apalutamide displayed good tolerability and safety profile in clinical studies. ... It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms …

Influenza A virus A/Singapore/gp1908/2015 IVR-180 (H1N1) hemagglutinin antigen (MDCK cell derived, propiolactone inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …

Neutral Protamine Hagedorn (NPH) insulin

Approved

Denosumab

Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss. Chemically, it consists of 2 heavy...
Approved
Matched Description: … September 2011 and in men with osteoporosis at high risk for fracture in September 2012. ... and women at high risk for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer in ... It further received additional indication approval to increase bone mass in men at high risk for fracture …

Capsicum oleoresin

Capsicum oleoresin is an oily organic resin derived from the fruit of plants in the Capsicum genus, such as chilli peppers. When the plants are finely ground, capsicum oleoresin is formed after the extraction process of capsaicin using oragnic solvents such as ethanol. It is commonly used as a culinary...
Approved
Matched Description: … Capsicum oleoresin is contained in pepper sprays when suspended in water, and acts an active lachrymatory ... Capsicum oleoresin is an oily organic resin derived from the fruit of plants in the Capsicum genus, such ... agent that induces irritation, lacrimation, pain, and temporary blindness when in contact with eyes. …

Niclosamide

Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms....
Approved
Investigational
Vet approved
Matched Description: … by Bayer in 1996. ... They are an even greater problem in domestic animals. ... Niclosamide, once marketed in the US under the brand name Niclocide, was voluntarily withdrawn from market …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Manidipine

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Approved
Investigational

Phosphoric acid

Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Xanthan gum

Xanthan gum is a polysaccharide gum derived from* Xanthomonas campestris* by a pure-culture fermentation process and purified by recovery with isopropyl alcohol. The major constituents include D-glucose, D-mannose, and D-glucuronic acid. Xanthan gum is a direct food additive permitted for direct addition to food for human consumption by the FDA....
Approved
Matched Description: … It is used as a thickening agent and stabilizer in emulsions. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Dimercaptosuccinic acid

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ansuvimab

Infection with pathogenic filoviruses, such as Zaire ebolavirus (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as 90%.[A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development. However, to date, the most successful...
Approved
Investigational
Matched Description: … humans, resulting in frequent outbreaks with case fatality rates as high as 90%. ... pathogenic filoviruses, such as _Zaire ebolavirus_ (Ebola virus, EBOV), can cause severe hemorrhagic fever in ... atoltivimab], [odesivimab], and [maftivimab]), the now approved ansuvimab, and ZMapp, which remains in …

Yttrium Y-90

Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer.
Approved
Investigational
Displaying drugs 426 - 450 of 11832 in total