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Displaying drugs 4651 - 4675 of 10637 in total

AVI-4557

AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently marketed drugs. Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and...
Investigational
Matched Description: … approximately half of currently marketed drugs. ... anxiety, cancer, and a number of other serious conditions. ... metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of …

1D-myo-inositol 1,4,5-trisphosphate

Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity...
Experimental
Matched Description: … released into the cytoplasm where it releases calcium ions from internal stores within the cell's ... , which is one of the phospholipids that make up the cell membrane. ... These calcium ions stimulate the activity of B kinase or calmodulin. …

Protocatechualdehyde

Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer cells and colorectal cancer cells by reducing the expression of pro-oncogenes...
Experimental
Matched Description: … the herb S. miltiorrhiza [A27224]. ... properties against human breast cancer cells and colorectal cancer cells by reducing the expression of ... naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of …

Mephedrone

Mephedrone has been investigated in Alcohol-Related Disorders and Amphetamine-Related Disorders.
Investigational
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine

25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It was discovered in 2014 at the University of Copenhagen.
Experimental
Matched Description: … It was discovered in 2014 at the University of Copenhagen. ... It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Aminopterin

Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment...
Investigational
Withdrawn
Matched Description: … In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less ... treatment of pediatric leukemia. ... Clinicians need to be aware of the characteristic teratologic effects of aminopterin and methotrexate …

Tertomotide

Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of LTX-315 as adjunct to tertomotide in Patients Following Curative Surgery for Carcinoma). It is a peptide vaccine that activates the immune system so that it recognizes and kills cancer cells. It is being developed by Pharmexa...
Investigational
Matched Description: … It is being developed by Pharmexa A/S. ... Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of …

Benfluorex

Benfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended withdrawing all benfluorex containing medicines on 18 December 2009. This recommendation was based on the risks (especially fenfluramine-like cardiovascular side-effects)...
Investigational
Withdrawn
Matched Description: … European Medicines Agency (EMA) recommended withdrawing all benfluorex containing medicines on 18 December 2009 …

Aconiazide

Investigational
Matched Categories: … Drugs for Treatment of Tuberculosis …

Bifemelane

Experimental
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

2,2-Dichloro-1-methanesulfinyl-3-methyl-cyclopropanecarboxylic acid [1-(4-bromo-phenyl)-ethyl]-amide

Experimental
Matched Iupac: … (1R,3R)-N-[1-(4-bromophenyl)ethyl]-2,2-dichloro-1-[(S)-methanesulfinyl]-3-methylcyclopropane-1-carboxamide …

Iclaprim

Investigational

Irsogladine

Irsogladine is under investigation in clinical trial NCT02581696 (The Drug-drug Interaction and Safety of Lafutidine and Irsogladine Maleate in Healthy Adult Volunteers).
Investigational
Matched Description: … Irsogladine is under investigation in clinical trial NCT02581696 (The Drug-drug Interaction and Safety of …

Hydroquinidine

Hydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).
Investigational
Matched Iupac: … (S)-[(1S,2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol …

Glucoraphanin

Glucoraphanin is under investigation in clinical trial NCT01879878 (Pilot Study Evaluating Broccoli Sprouts in Advanced Pancreatic Cancer [POUDER Trial]).
Investigational

Gestonorone

Gestonorone is often mistaken for gestonorone capproate which has a different chemical structure.
Experimental
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Phenoxypropazine

Phenoxypropazine is a non-selective and irreversible monoamine oxidase enzyme inhibitor (MAOI), belonging to the hydrazine chemical class. It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic potential.
Withdrawn
Matched Description: … It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Alphacetylmethadol

A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Experimental
Illicit
Matched Description: … A narcotic analgesic with a long onset and duration of action. ... It is used mainly in the treatment of narcotic dependence. [PubChem] …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Bezitramide

Bezitramide is a narcotic analgesic which was discovered in 1961, clinically tested around the 1970's , and marketed under the name Burgodin. After cases of fatal overdose in the Netherlands in 2004 the drug was withdrawn from the market. Bezitramide has never been FDA approved and is currently a schedule...
Experimental
Illicit
Withdrawn
Matched Description: … Bezitramide is a narcotic analgesic which was discovered in 1961, clinically tested around the 1970's ... After cases of fatal overdose in the Netherlands in 2004 the drug was withdrawn from the market. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Iodohippuric acid

Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults).
Investigational
Matched Description: … Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal …
Matched Categories: … Diagnostic Uses of Chemicals …

Chlorine

Chlorine is a stongly oxidizing agent and the third most electronegative element which belongs to the group of halogens with the atomic number 17 and symbol Cl. Being a yellow-green gas at room temperature, chlorine is the second most abundant halogen on Earth. It is commonly used in sanitation, disinfection...
Experimental
Matched Description: … is a stongly oxidizing agent and the third most electronegative element which belongs to the group of …
Matched Categories: … Weapons of Mass Destruction …

Trafermin

Investigational
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Dexchlorpheniramine

Dexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug indicated for adjunctive therapy for allergic and anaphylactic reactions. It is an antihistamine drug with anticholinergic (drying) and sedative actions. It disrupts histamine signaling by competing with histamine...
Experimental
Investigational
Matched Description: … Dexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. …

Milbemycin oxime

Vet approved
Matched Iupac: … (1'R,2R,4'S,5S,6R,8'R,10'E,13'R,14'E,16'E,20'R,21'Z,24'S)-24'-hydroxy-21'-(hydroxyimino)-5,6,11',13', ... oxane-2,6'-tetracyclo[15.6.1.1^{4,8}.0^{20,24}]pentacosane]-10',14',16',22'-tetraen-2'-one; (1'R,2R,4'S, ... 5S,6R,8'R,10'E,13'R,14'E,16'E,20'R,21'Z,24'S)-6-ethyl-24'-hydroxy-21'-(hydroxyimino)-5,11',13',22'-tetramethyl …

Zoliflodacin

Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea.
Investigational
Matched Iupac: … (4'R,6'S,7'S)-17'-fluoro-4',6'-dimethyl-13'-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]-5',15'-dioxa-2' …
Matched Description: … Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea. …
Displaying drugs 4651 - 4675 of 10637 in total