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Displaying drugs 26 - 50 of 192 in total
Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies directed against red blood cell surface antigens cause hemolysis at low (3-4°C) temperatures.[A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in the elderly.[A245159,L40114] In approximately 90% of cases,...
Approved
Investigational
Matched Description: … on erythrocytes - these antibodies react optimally at 4°C and are therefore referred to as "cold agglutinin ... [A245159] Pharmacologic strategies have included the targeting of B-cells with agents like [rituximab ... In approximately 90% of cases, patients develop immunoglobulin M (IgM) autoantibodies towards the I antigen
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Iupac: … ]propanamido]-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido]-5-carbamimidamidopentanoyl ... (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(1-benzyl-1H-imidazol-4-yl)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)- ... 3-(1H-imidazol-4-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido …
Matched Description: … treatment for children with central precocious puberty (CPP) due to their capacity to reduce LH levels and
Matched Categories: … Hormones and Related Agents ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote normal immune responses that attack tumour...
Approved
Investigational
Matched Description: … Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint ... unresectable non-small cell lung cancer (NSCLC), only if PD-L1 is expressed in ≥ 1% of tumour cells and ... L12627] On March 27, 2020, durvalumab was approved by the FDA for use in combination with [etoposide] and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Iupac: … 4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl}-2 …
Matched Description: … Higher prostate-specific antigen (PSA) and shorter PSA doubling time (PSA DT) are associated with a higher ... Unlike bicalutamide, apalutamide antagonized AR-mediated signaling in AR overexpressing human CRPC cell ... In mice bearing human CRPC xenograft models, apalutamide treatment produced tumor regressions in a dose-dependent …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …
Gallium (Ga) 68 prostate-specific membrane antigen (PSMA)-11, or Ga-68 gozetotide, is a radiopharmaceutical agent used to identify and assess prostate-specific membrane antigen (PSMA)-positive lesions in adult men with prostate cancer during positron emission tomography (PET). Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries...
Approved
Matched Iupac: … carbamoyl]ethyl}-2-hydroxyphenyl)methyl](carboxylatomethyl)amino}ethyl)(carboxylatomethyl)amino]methyl}-4- …
Matched Description: … agent used to identify and assess prostate-specific membrane antigen (PSMA)-positive lesions in adult ... In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended Ga-68 gozetotide ... L26981] Prostate cancer is one of the most commonly diagnosed cancers among men in Western countries and
Matched Categories: … Indicators and Reagents …
Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. Avelumab was first approved by the FDA on March 23, 2017. On September 18 and December 18 of the same year,...
Approved
Investigational
Matched Description: … to block its interaction with its receptors found on T cells and antigen-presenting cells. ... Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) ... ] and Health Canada,[L48171] respectively. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Talimogene laherparepvec is an oncolytic treatment used in local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with recurrent melanoma. It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. It specifically replicates within...
Approved
Experimental
Investigational
Matched Description: … It is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage ... It specifically replicates within tumor cells and causes lysis. ... colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. …
Matched Categories: … Antineoplastic cell and gene therapy ... Antineoplastic and Immunomodulating Agents …
Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen 2...
Approved
Investigational
Matched Description: … A193671] One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen ... Commission and Health Canada respectively. ... [L13002, A193674] Sacituzumab govitecan was granted FDA approval on April 22nd, 2020 and is marketed …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure prophylaxis against rabies.
Approved
Matched Synonyms: … Rabies virus vaccine wistar strain PM-1503-3M (human) ... Rabies virus strain PM-1503-3M antigen (propiolactone inactivated) …
Matched Name: … Rabies virus inactivated antigen, B
Matched Description: … Inactivated rabies virus antigen B is a component of rabies vaccines used for pre- and post-exposure …
Matched Categories: … Immune Sera and Immunoglobulins …
Matched Products: … RABIES VACCINE FOR HUMAN USE (VERO CELL), FREEZE-DRIED FINAL BULK …
Human papillomavirus type 33 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 33. The vaccine is prepared from the purified...
Approved
Matched Synonyms: … L1 protein, Human papillomavirus type 33 Vaccine ... Recombinant human papillomavirus type 33 L1 protein …
Matched Name: … Human papillomavirus type 33 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 33 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular ... by Human Papillomavirus (HPV) type 33. ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Synonyms: … L1 protein, Human papillomavirus type 6 Vaccine ... Recombinant human papillomavirus type 6 L1 protein …
Matched Name: … Human papillomavirus type 6 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human ... by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Matched Categories: … Inactivated Human Papillomavirus Vaccine …
Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Synonyms: … L1 protein, Human papillomavirus type 16 Vaccine ... Recombinant human papillomavirus type 16 L1 protein …
Matched Name: … Human papillomavirus type 16 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human ... by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Human papillomavirus 16 ... Inactivated Human Papillomavirus Vaccine …
Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used to prevent the immunological condition known as Rh disease (or hemolytic disease of newborn). Rho (D) immune globulin is available as a sterile, lyophilized or liquid gamma globulin (IgG) fraction containing antibodies to the...
Approved
Investigational
Matched Synonyms: … Human anti-D immunoglobulin ... Immunoglobulin human anti-RH ... Rho D immune globulin human
Matched Name: … Human Rho(D) immune globulin …
Matched Description: … Immune globullin was purified via ion-exchange chromatography method and prepared from pools of human ... (D antigen) under the name Rhophylac (IM/IV). ... Human Rho(D) immune globulin is a medicine given by intramuscular or intravenous injection that is used …
Matched Categories: … Human Immunoglobulin G ... Endogenous Antigen Neutralization ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) and purified from extraneous plasma-derived...
Approved
Matched Synonyms: … F8 protein, human ... factor VIII, human ... Factor VIII (human) …
Matched Name: … Antihemophilic factor human
Matched Description: … Factor VIII, but does not contain the B-domain, which has no known biological function and [DB11607] ... Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) ... Antihemophilic factor human is approved by the Food and Drug Administration for use in hemophilia A ( …
Matched Mixtures name: … Haemate P Powder and solvent for solution for injection or infusion ... Wilate 500, 500 IU VWF/500 IU FVIII, Powder and Solvent for Solution for Injection ... Wilate 1000, 1000 IU VWF/1000 IU FVIII, Powder and Solvent for Solution for Injection …
Matched Categories: … Human Antihemophilic Factors ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250 IU ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 1000 IU …
Vibrio cholerae CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against Vibrio cholerae serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by Vibrio cholerae, which is gram-negative bacteria. Two serogroups of V. cholerae, O1 and O139, are causative...
Approved
Investigational
Matched Name: … Vibrio cholerae CVD 103-HgR strain live antigen
Matched Description: … _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization ... [A244489] The FDA approved the cholera vaccine containing _Vibrio cholerae_ CVD 103-HgR strain live ... antigen under the brand name Vaxchora in June 2016, making it the first vaccine indicated for cholera …
Matched Products: … Cholera Vaccine Strain 35a-and 41 8000m/cc …
Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing...
Approved
Matched Synonyms: … Anthrax immune globulin human ... Anthrax immune globulin (human) ... Anthrax immunoglobulin (human) …
Matched Name: … Anthrax immune globulin human
Matched Description: … Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. ... result is a solution for slow IV infusion containing polyclonal antibodies that bind the protective antigen ... (PA) component of Bacillus anthracis lethal and edema toxins. …
Matched Categories: … Human Immunoglobulin ... Amino Acids, Peptides, and Proteins …
Human cord blood hematopoietic progenitor cells consist of hematopoietic progenitor cells, monocytes, lymphocytes, and granulocytes from human cord blood. They are used during allogeneic unrelated and related hematopoietic stem cell transplantation procedures in patients with disorders affecting the hematopoietic system that are inherited, acquired, or result from myeloablative treatment. Human...
Approved
Matched Name: … Human cord blood hematopoietic progenitor cell …
Matched Description: … marrow transplantation; it allows shorter time to transplant and tolerance of 1–2 human leukocyte antigen ... lymphocytes, and granulocytes from human cord blood. ... Human umbilical cord is a rich source of hematopoietic stem cells and progenitor cells that are capable …
Human papillomavirus type 45 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 45. The vaccine is prepared from the purified...
Approved
Matched Synonyms: … L1 protein, Human papillomavirus type 45 Vaccine ... Recombinant human papillomavirus type 45 L1 protein …
Matched Name: … Human papillomavirus type 45 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 45 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular ... by Human Papillomavirus (HPV) type 45. ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Human papillomavirus type 52L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 52 The vaccine is prepared from the purified virus-like...
Approved
Matched Synonyms: … L1 protein, Human papillomavirus type 52 Vaccine ... Recombinant human papillomavirus type 52 L1 protein …
Matched Name: … Human papillomavirus type 52 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 52L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused ... by Human Papillomavirus (HPV) type 52 The vaccine is prepared from the purified virus-like particles …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Human papillomavirus type 31 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 31. The vaccine is prepared from the purified...
Approved
Matched Synonyms: … L1 protein, Human papillomavirus type 31 Vaccine ... Recombinant human papillomavirus type 31 L1 protein …
Matched Name: … Human papillomavirus type 31 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 31 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular ... by Human Papillomavirus (HPV) type 31. ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Approved
Investigational
Matched Name: … Human papillomavirus type 18 L1 capsid protein residues 2-472 antigen
Human papillomavirus type 18 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Synonyms: … L1 protein, Human papillomavirus type 18 Vaccine ... Recombinant human papillomavirus type 18 L1 protein …
Matched Name: … Human papillomavirus type 18 L1 capsid protein antigen
Matched Description: … Human papillomavirus type 18 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human ... by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …
Matched Categories: … Inactivated Human Papillomavirus Vaccine …
Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines. According to the Centers for Disease Control...
Approved
Investigational
Matched Synonyms: … Hepatitis B immune globulin human ... Hepatitis B immune globulin (human) ... Human hepatitis B immunoglobulin …
Matched Name: … Hepatitis B immune globulin …
Matched Description: … HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen ... According to the Centers for Disease Control and Prevention (CDC), the hepatitis B vaccine was the first ... The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus. …
Matched Categories: … Human Immunoglobulin ... hepatitis B immunoglobulin ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Matched Products: … ./4 ml ... HepaGam B ... Hyperhep B
Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4 (233-PROLINE,239-ALANINE,240-ALANINE,410-LEUCINE,414-LYSINE), ANTI-(HUMAN CD3 ANTIGEN ... ) (HUMAN MONOCLONAL JNJ-63483043 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL JNJ-63483043 .LAMBDA ... ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY, BISPECIFIC …
Matched Description: … [A260890] The Committee for Medicinal Products for Human Use (CHMP) of the EMA recommended conditional ... arm comprising a heavy and light chain. ... It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used in the prophylaxis of Pertussis (whooping cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human respiratory tract.
Approved
Matched Name: … Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) …
Matched Description: … Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used ... cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human
Displaying drugs 26 - 50 of 192 in total