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Displaying drugs 476 - 500 of 13963 in total

Oteracil

Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy. Approved by the European Medicines Agency (EMA) in March 2011, Oteracil is available in combination with DB09257 and DB09256 within the commercially available product "Teysuno". The main active ingredient in Teysuno is DB09256,...
Approved
Matched Description: … The main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic ... able to insert itself into strands of DNA and RNA, thereby halting the replication process necessary for ... Approved by the European Medicines Agency (EMA) in March 2011, Oteracil is available in combination with …

Omadacycline

Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in animal models at treating increasingly problematic, clinically prevalent...
Approved
Investigational
Matched Description: … Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown ... Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections ... cause diseases such as pneumonias, urinary tract infections, skin diseases and blood-borne infections in …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Icodextrin

Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport...
Approved
Investigational
Matched Description: … It is injected as a solution into the peritoneal cavity. ... dialysis (APD) for patients with end-stage renal disease. ... It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Hydroxyprogesterone caproate

Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug...
Approved
Investigational
Matched Iupac: … 11aS)-1-acetyl-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy. ... FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention ... Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999.[L46118] The U.S. …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Apalutamide

Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Description: … In a randomized trial, the median metastasis-free survival for patients taking apalutamide was 40.5 months ... compared to 16.2 months for patients taking a placebo [L1295]. ... In mice bearing human CRPC xenograft models, apalutamide treatment produced tumor regressions in a dose-dependent …

Calcium glubionate anhydrous

Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Approved
Matched Description: … levels in people who do not get enough calcium from their diets. ... Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium …

Interferon alfa-n3

Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms including 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).
Approved
Investigational
Matched Description: … Purified, natural (n is for natural) human interferon alpha proteins (consists of 3 forms or polymorphisms …

Berotralstat

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat is strictly used to...
Approved
Matched Description: … Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary ... [L26661] It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the ... FDA on December 3, 2020, as the first once-daily oral therapy to prevent angioedema attacks of HAE in …
Matched Categories: … Drugs Used in Hereditary Angioedema …

Oxetacaine

Oxetacaine, also called oxethazaince, is a potent surface analgesic with the molecular formula N, N-bis-(N-methyl-N-phenyl-t-butyl-acetamide)-beta-hydroxyethylamine that conserves its unionized form at low pH levels. Its actions have shown to relieve dysphagia, relieve pain due to reflux, chronic gastritis, and duodenal ulcer. Oxetacaine is approved by Health Canada since 1995 for...
Approved
Investigational
Matched Description: … [A33104] Oxetacaine is approved by Health Canada since 1995 for its use as an antacid combination in ... Oxetacaine, also called oxethazaince, is a potent surface analgesic with the molecular formula N, N-bis ... N-methyl-N-phenyl-t-butyl-acetamide)-beta-hydroxyethylamine that conserves its unionized form at low pH levels …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Daprodustat

Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … [A254172] In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia. ... [A254157] A phase 3 clinical trial (NCT02879305) found that in patients with CKD undergoing dialysis, ... Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that …

Dactinomycin

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Description: … A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces ... As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index …
Matched Products: … DACTINOMYCIN FOR INJECTION 0.5 mg/vial …

Pegaptanib

Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.
Approved
Investigational
Matched Description: … Pegaptanib is a polynucleotide aptamer. ... Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces …
Matched Categories: … Vascular Endothelial Growth Factor A …

Polidocanol

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural...
Approved
Matched Description: … The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization ... in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity ... (n) of approximately 9 and a mean molecular weight of approximately 600. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Sclerosing Agents for Local Injection …

Ciclopirox

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.
Approved
Investigational
Matched Description: … Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a ... synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. ... In particular, the agent is especially effective in treating Tinea versicolor. …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Demeclocycline

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Approved
Matched Description: … Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer ... A tetracycline analog having a 7-chloro and a 6-methyl. …
Matched Categories: … Antibiotics for Topical Use ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Rozanolixizumab

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange. It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly generalized myasthenia...
Approved
Investigational
Matched Description: … [A260207] AChR is vital for signal transduction in the neuromuscular junctions (NMJ) by generating ... [A260177] It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly ... [L47122] In June 2023, Rozanolixizumab-noli was approved by the FDA under Priority Review for the treatment …

Sulconazole

Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis infections.[L44592,L44597] Sulconazole appears to be effective...
Approved
Matched Description: … Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream ... [L44592,L44597] Sulconazole appears to be effective and well-tolerated in the treatment of superficial ... derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Dermatological Use …

Florbetapir (18F)

Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Description: … that plays a key role in Alzheimer's Disease pathogenesis. ... who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline. ... Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography (PET) imaging …

Ambenonium

Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.
Approved
Matched Description: … Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. …

Capecitabine

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Approved
Investigational
Matched Description: … Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor ... Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast …
Matched Categories: … Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index …

Ivosidenib

Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivosidenib was granted accelerated approval by the FDA...
Approved
Investigational
Matched Description: … a positive opinion of ivosidenib and recommended it be granted marketing authorization for the treatment ... Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. ... [L48781] In February 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Boric acid

Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes . It...
Approved
Matched Description: … Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical ... in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes ... Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Crizotinib

Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers...
Approved
Investigational
Matched Description: … Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase ... treating NSCLC in patients with this type of rearrangement. ... [A250785] Crizotinib was the first-in-class drug used to treat ALK-positive tumors. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Tovorafenib

Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. It was granted accelerated approval by the FDA, making it the first FDA approval of a systemic therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements. BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation,...
Approved
Investigational
Matched Description: … therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements. ... [L50587] BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation, and differentiation ... Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. …

Lanthanum carbonate

Lanthanum carbonate is a phosphate binder marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse effects. It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by binding to...
Approved
Matched Description: … It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by ... binding to dietary phosphate and preventing its absorption in the intestine. ... Lanthanum carbonate is a phosphate binder marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Displaying drugs 476 - 500 of 13963 in total