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Displaying drugs 501 - 525 of 10443 in total

Polatuzumab vedotin

Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable linker called maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl (mc-vc-PAB) that covalently attaches MMAE to...
Approved
Investigational
Matched Description: … Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an ... L6658] Polatuzumab vedotin was granted accelerated FDA approval on June 10, 2019 [A254936] and was approved …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Miglitol

Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol should be taken at the start...
Approved
Matched Categories: … Blood Glucose Lowering Agents ... Hypoglycemia-Associated Agents …

Topiramate

Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy...
Approved
Matched Description: … [A175249] It was initially approved by the FDA in 1996. ... In 2004, topiramate was approved for the prevention of migraine in adults. ... [A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination …
Matched Categories: … Anti-Obesity Agents ... Neuroprotective Agents ... Central Nervous System Agents …

Dihydrotachysterol

A vitamin D that can be regarded as a reduction product of vitamin D2.
Approved
Matched Categories: … Bone Density Conservation Agents …

Sodium stibogluconate

Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials. Sodium stibogluconate is sold in the UK as Pentostam (manufactured by GlaxoSmithKline). Widespread resistance has limited the utility of sodium stibogluconate,...
Approved
Investigational
Matched Description: … It is also being investigated as an anti-tumor agent. …
Matched Categories: … Anti-Infective Agents ... Antiparasitic Agents ... Antiplatyhelmintic Agents ... Agents Against Leishmaniasis and Trypanosomiasis …

Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an …

Flutamide

An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Approved
Investigational
Matched Description: … An antiandrogen with about the same potency as cyproterone in rodent and canine species. …
Matched Categories: … Antineoplastic Agents ... Antineoplastic Agents, Hormonal ... Methemoglobinemia Associated Agents ... Hormone Antagonists and Related Agents ... Antineoplastic and Immunomodulating Agents …

Chlorhexidine

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of...
Approved
Vet approved
Withdrawn
Matched Description: … [L11512] It is one of the most common skin and mucous membrane antiseptic agents in use today. …
Matched Categories: … Dental Agents ... Anti-Infective Agents ... Anti-Infective Agents, Local …

Ethylhexyl methoxycrylene

Ethylhexyl methoxycrylene is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states . It returns UV filters to their ground states without absorbing sunlight . It is used as a solvent for crystalline UV filters and is easily emulsified and suitable...
Approved
Experimental

Kappadione

Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Description: … Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved …

Corifollitropin alfa

Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva...
Approved
Investigational
Matched Description: … the elevated effectiveness of this drug, however, warns at the same time against the possibility of an ... increased risk of ovarian hyperstimulation in the high responder study group of women [L2276], [A32526 …

Tyrothricin

Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus Brevibacillus parabrevis [L4019, L4021, A32851] which was previously categorized as Bacillus brevis and Bacillus aneurinolyticus . This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely of the six predominant tyrocidines, TrcA/A1,...
Approved
Matched Description: … Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... Anti-Infective Agents, Local …

Perflutren

Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the...
Approved
Matched Description: … The difference in density between the gas-filled bubbles and the blood around them creates an increased ... echocardiography, activated Perflutren enhances images of the inner edges or borders of the heart, producing an …
Matched Categories: … QTc Prolonging Agents ... Moderate Risk QTc-Prolonging Agents …

Padimate O

Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA . It is a structurally-related compound to DB02362 that absorbs UV-B rays to prevent photodamage. It penetrates human skin, and is shown to induce non-ligatable strand...
Approved
Matched Description: … Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in …
Matched Categories: … Sunscreen Agents ... Protective Agents ... Radiation-Protective Agents …

Novobiocin

Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) Novobiocin sodium, a salt form of novobiocin, was initially approved in September 1964...
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … Novobiocin is an antibiotic compound derived from _Streptomyces niveus_. ... Extra Pharmacopoeia, 30th ed, p189) Novobiocin sodium, a salt form of novobiocin, was initially approved …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents …

Terlipressin

Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor. It is a prodrug of lypressin, or lysine vasopressin. Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for the V1 receptor. As a potent vasopressor, terlipressin has been...
Approved
Investigational
Matched Description: … [A252672] The drug was first approved by the FDA in September 2022.[L43217] ... Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as …
Matched Categories: … Cardiovascular Agents ... QTc Prolonging Agents ... Vasoconstrictor Agents ... Moderate Risk QTc-Prolonging Agents …

Guselkumab

Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in...
Approved
Investigational
Matched Description: … IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the ... Developed by Janssen, the subcutenous injection form of guselkumab was approved in July 2017 under the …
Matched Categories: … Immunosuppressive Agents ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …

Eflornithine

Eflornithine is an irreversible ornithine decarboxylase inhibitor originally developed as a treatment for human African trypanosomiasis. Further research has also implicated ornithine decarboxylase in other conditions like facial hirsutism and cancer, especially when ornithine decarboxylase is highly upregulated in tumor cells.[A4112, A262834] Additionally, ornithine decarboxylase is activated by c-myc or...
Approved
Withdrawn
Matched Description: … Eflornithine is an irreversible ornithine decarboxylase inhibitor originally developed as a treatment ... [A262839] In 1960 and 2000, the FDA approved eflornithine under the brand names ORNIDYL and VANIQUA ... [A262823,L49318] Subsequently, on December 14, 2023, the FDA approved eflornithine again but under the …
Matched Categories: … Anti-Infective Agents ... Antiparasitic Agents ... Antineoplastic Agents ... Trypanocidal Agents ... Skin and Mucous Membrane Agents …

Histrelin

Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Description: … gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an ... As the product Supprelin LA, histrelin is indicated for the treatment of CPP in children (approved by ... [L41715] The Vantas product was approved by the FDA in October 2004 for the palliative treatment of this …
Matched Categories: … QTc Prolonging Agents ... Hormones and Related Agents ... Hyperglycemia-Associated Agents ... Potential QTc-Prolonging Agents ... Antineoplastic and Immunomodulating Agents …

Burosumab

Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor ... Food and Drug Administration approved Crysvita (burosumab) in April 2018. ... This is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia …

Influenza A virus A/Brisbane/59/2007 (H1N1) hemagglutinin antigen (formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Investigational
Matched Description: … from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an …

D-alpha-Tocopherol acetate

Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the...
Approved
Nutraceutical
Vet approved
Matched Categories: … Protective Agents …

Safinamide

Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Approved
Investigational
Matched Description: … It was approved in Europe in February 2015, and in the United States on March 21, 2017. …
Matched Categories: … Antidepressive Agents ... Dopamine Agents ... Agents that produce hypertension ... Agents that reduce seizure threshold …

Fondaparinux

Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in heparin and HS...
Approved
Investigational
Matched Description: … Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group …
Matched Categories: … Hematologic Agents ... Cardiovascular Agents ... Fibrin Modulating Agents …

Meperidine

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Approved
Matched Categories: … Antidepressive Agents ... Serotonin Agents ... Sensory System Agents ... Central Nervous System Agents ... Agents that reduce seizure threshold …
Displaying drugs 501 - 525 of 10443 in total