Displaying drugs 551 - 575 of 2701 in total
Edetic acid
A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Approved
Vet approved
Matched Synonyms: … Edetic acid ... Acido edetico ... Acide edetique …
Matched Name: … Edetic acid …
Matched Iupac: … 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid …
Matched Description: … It is used in pharmaceutical manufacturing and as a food additive. …
Matched Categories: … Diet, Food, and Nutrition ... Acids, Acyclic ... Carboxylic Acids ... Calcium Chelating Agents ... Calcium Chelating Activity …
Matched Products: … SODIO CALCIO EDETATO MONICO ... SODIO CALCIO EDETATO S.A.L.F. …
Matched Name: … Edetic acid …
Matched Iupac: … 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid …
Matched Description: … It is used in pharmaceutical manufacturing and as a food additive. …
Matched Categories: … Diet, Food, and Nutrition ... Acids, Acyclic ... Carboxylic Acids ... Calcium Chelating Agents ... Calcium Chelating Activity …
Matched Products: … SODIO CALCIO EDETATO MONICO ... SODIO CALCIO EDETATO S.A.L.F. …
Avoralstat
Avoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema.
Investigational
Matched Synonyms: … -2-carboxylic acid ... -2-carboxylic acid ... -2-carboxylic acid …
Matched Iupac: … -2-carboxylic acid ... 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl)carbamoyl]pyridine …
Matched Description: … Avoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema. …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... Acids, Heterocyclic …
Matched Iupac: … -2-carboxylic acid ... 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl)carbamoyl]pyridine …
Matched Description: … Avoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema. …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... Acids, Heterocyclic …
Pyridoxamine-5'-Phosphate
Experimental
Matched Synonyms: … Pyridoxamine phosphate …
Matched Name: … Pyridoxamine-5'-Phosphate …
Matched Iupac: … {[4-(aminomethyl)-5-hydroxy-6-methylpyridin-3-yl]methoxy}phosphonic acid …
Matched Name: … Pyridoxamine-5'-Phosphate …
Matched Iupac: … {[4-(aminomethyl)-5-hydroxy-6-methylpyridin-3-yl]methoxy}phosphonic acid …
Dimercaptosuccinic acid
Approved
Experimental
Matched Synonyms: … 2,3-Dimercaptosuccinic acid ... 2,3-Dimercaptobutanedioic acid …
Matched Name: … Dimercaptosuccinic acid …
Matched Iupac: … 2,3-disulfanylbutanedioic acid …
Matched Salts name: … Sodium dimercaptosuccinic acid …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Dicarboxylic Acids …
Matched Products: … Dimercaptosuccinic Acid DMSA …
Matched Name: … Dimercaptosuccinic acid …
Matched Iupac: … 2,3-disulfanylbutanedioic acid …
Matched Salts name: … Sodium dimercaptosuccinic acid …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Dicarboxylic Acids …
Matched Products: … Dimercaptosuccinic Acid DMSA …
Chloric acid
Approved
Experimental
Matched Name: … Chloric acid …
Matched Iupac: … chloric acid …
Matched Mixtures name: … Polyethylene Glycol 3350 and electrolytes - Unflavored …
Matched Products: … Hemodialysis Acid Concentrate …
Matched Iupac: … chloric acid …
Matched Mixtures name: … Polyethylene Glycol 3350 and electrolytes - Unflavored …
Matched Products: … Hemodialysis Acid Concentrate …
DL-Methylephedrine
Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world , , . The abuse of methylephedrine-containing medications has been reported in Japan. Methylephedrine is not legally available in the United States, but has been identified in cases of drug abuse .
Approved
Matched International brands: … dl-Methylephedrine Hydrochloride 10% Metal ... dl-Methylephedrine Hydrochloride 10% Maruishi ... dl-Methylephedrine Hydrochloride 10% Sanwa …
Matched Description: … Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications …
Matched Salts name: … DL-Methylephedrine hydrochloride …
Matched Description: … Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications …
Matched Salts name: … DL-Methylephedrine hydrochloride …
Isoniazid
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Approved
Investigational
Matched Synonyms: … Pyridine-4-carboxylic acid hydrazide ... Isonicotinic acid hydrazide …
Matched Iupac: … pyridine-4-carbohydrazide …
Matched Categories: … isoniazid, sulfamethoxazole, trimethoprim and pyridoxine ... Acids, Heterocyclic ... Isonicotinic Acids ... Fatty Acid Synthesis Inhibitors ... ethambutol and isoniazid …
Matched Iupac: … pyridine-4-carbohydrazide …
Matched Categories: … isoniazid, sulfamethoxazole, trimethoprim and pyridoxine ... Acids, Heterocyclic ... Isonicotinic Acids ... Fatty Acid Synthesis Inhibitors ... ethambutol and isoniazid …
Lactobacillus plantarum
Lactobacillus plantarum is a member of Lactobacillus, or lactic acid bacteria, that it is widely used in the food industry as a microbial starter and probiotic microorganism. It is considered to be one of versatile species that carry out fermentative and metabolic processes, while exhibiting an antagonistic activity against pathogenic...
Investigational
Matched Description: … , bacteriocins, and antimicrobial peptides [A27208]. ... in the food industry as a microbial starter and probiotic microorganism. ... while exhibiting an antagonistic activity against pathogenic and spoilage microorganisms. …
Matched Products: … Kimchi Lactic Acid 1000 …
Matched Products: … Kimchi Lactic Acid 1000 …
Ferrous glycine sulfate
Approved
Matched Synonyms: … Iron(II) glycine sulfate …
Matched Iupac: … lambda2-iron(2+) sulfuric acid bis(2-aminoacetate) …
Matched Categories: … Blood and Blood Forming Organs ... Iron Preparations ... Iron Bivalent, Oral Preparations …
Matched Iupac: … lambda2-iron(2+) sulfuric acid bis(2-aminoacetate) …
Matched Categories: … Blood and Blood Forming Organs ... Iron Preparations ... Iron Bivalent, Oral Preparations …
Icosapent
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Approved
Nutraceutical
Matched Synonyms: … Timnodonic acid ... Icosapentaenoic acid ... Eicosapentaenoic acid …
Matched Iupac: … (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid …
Matched Description: … disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane ... -2 and prostaglandin-2 families. ... It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. …
Matched Mixtures name: … FOLEX 308MG/350 MCG KAPLI TABLET, 30 ADET ... FOLEX 308MG/350 MCG KAPLI TABLET, 100 ADET …
Matched Categories: … Fatty Acids ... Fatty Acids, Omega-3 ... Fatty Acids, Unsaturated …
Matched Products: … FOLAS 5 MG TABLET, 50 ADET …
Matched Iupac: … (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid …
Matched Description: … disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane ... -2 and prostaglandin-2 families. ... It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. …
Matched Mixtures name: … FOLEX 308MG/350 MCG KAPLI TABLET, 30 ADET ... FOLEX 308MG/350 MCG KAPLI TABLET, 100 ADET …
Matched Categories: … Fatty Acids ... Fatty Acids, Omega-3 ... Fatty Acids, Unsaturated …
Matched Products: … FOLAS 5 MG TABLET, 50 ADET …
Casein
Casein allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Calcium caseinate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Fluids and Secretions ... Diet, Food, and Nutrition …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Fluids and Secretions ... Diet, Food, and Nutrition …
Oxidronic acid
Approved
Matched Synonyms: … Acido oxidronico ... Oxidronic acid ... Acidum oxidronicum …
Matched Name: … Oxidronic acid …
Matched Iupac: … [hydroxy(phosphono)methyl]phosphonic acid …
Matched Name: … Oxidronic acid …
Matched Iupac: … [hydroxy(phosphono)methyl]phosphonic acid …
Omburtamab I-131
Investigational
Matched Synonyms: … Iodine (131I) omburtamab …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Iodine Isotopes ... Iodine (131I) Compounds ... iodine (131I) omburtamab …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Iodine Isotopes ... Iodine (131I) Compounds ... iodine (131I) omburtamab …
Flufenamic acid
An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16)
Approved
Matched Synonyms: … Flufenamic acid ... acide flufénamique ... Acidum flufenamicum …
Matched Name: … Flufenamic acid …
Matched Iupac: … 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid …
Matched Description: … An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. ... It is used in musculoskeletal and joint disorders and administered by mouth and topically. …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Acids, Carbocyclic ... Carboxylic Acids ... flufenamic acid …
Matched Name: … Flufenamic acid …
Matched Iupac: … 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid …
Matched Description: … An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. ... It is used in musculoskeletal and joint disorders and administered by mouth and topically. …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Acids, Carbocyclic ... Carboxylic Acids ... flufenamic acid …
Etazolate
EHT 0202 is developed to treat neurodegenerative disorders by ExonHit Therapeutics.
Investigational
Matched Synonyms: … 1H-PYRAZOLO(3,4-B)PYRIDINE-5-CARBOXYLIC ACID, 1-ETHYL-4-((1-METHYLETHYLIDENE)HYDRAZINO)-, ETHYL ESTER …
Matched Categories: … Acids, Heterocyclic ... Nicotinic Acids …
Matched Categories: … Acids, Heterocyclic ... Nicotinic Acids …
Orotic acid
Investigational
Matched Synonyms: … Orotic acid ... Acido orotico ... Acidum oroticum …
Matched Name: … Orotic acid …
Matched Iupac: … 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
Matched Categories: … Acids, Heterocyclic …
Matched Name: … Orotic acid …
Matched Iupac: … 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
Matched Categories: … Acids, Heterocyclic …
Calcium lactate gluconate
Experimental
Matched Name: … Calcium lactate gluconate …
Matched Mixtures name: … CALCIUM SANDOZ ... CALCIUM SANDOZ FORTE ... CALCIUM SANDOZ FORTE …
Matched Categories: … Alimentary Tract and Metabolism ... Calcium Salts ... calcium lactate gluconate …
Matched Mixtures name: … CALCIUM SANDOZ ... CALCIUM SANDOZ FORTE ... CALCIUM SANDOZ FORTE …
Matched Categories: … Alimentary Tract and Metabolism ... Calcium Salts ... calcium lactate gluconate …
Cromoglicic acid
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Approved
Matched Synonyms: … Cromoglicic acid ... Cromoglycic acid ... Acido Cromoglicico …
Matched Name: … Cromoglicic acid …
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid …
Matched Description: … It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect …
Matched Categories: … Alimentary Tract and Metabolism ... Decongestants and Antiallergics ... reproterol and sodium cromoglicate ... salbutamol and sodium cromoglicate ... cromoglicic acid …
Matched Name: … Cromoglicic acid …
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid …
Matched Description: … It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect …
Matched Categories: … Alimentary Tract and Metabolism ... Decongestants and Antiallergics ... reproterol and sodium cromoglicate ... salbutamol and sodium cromoglicate ... cromoglicic acid …
Diatrizoate
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Approved
Vet approved
Matched Synonyms: … Urografin acid ... Diatrizoic acid ... Methalamic acid …
Matched Iupac: … 3,5-diacetamido-2,4,6-triiodobenzoic acid …
Matched Description: … , and urography. ... As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography …
Matched Mixtures name: … Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium …
Matched Salts name: … Diatrizoic acid dihydrate …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... diatrizoic acid ... Triiodobenzoic Acids …
Matched Iupac: … 3,5-diacetamido-2,4,6-triiodobenzoic acid …
Matched Description: … , and urography. ... As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography …
Matched Mixtures name: … Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium …
Matched Salts name: … Diatrizoic acid dihydrate …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... diatrizoic acid ... Triiodobenzoic Acids …
Vancomycin
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatment of...
Approved
Matched Iupac: … }.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid …
Matched Description: … kidneys and the inner ear. ... It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to ... liquid treatment option available for the the treatment of _Clostridium difficile_ associated diarrhea and …
Matched Mixtures name: … Vancomycin Hydrochloride ... Vancomycin Hydrochloride ... Vancomycin Hydrochloride …
Matched Salts name: … Vancomycin hydrochloride …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Alimentary Tract and Metabolism …
Matched Products: … Vancomycin Hydrochloride ... Vancomycin Hydrocloride ... Vancomycin hydrochloride …
Matched Description: … kidneys and the inner ear. ... It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to ... liquid treatment option available for the the treatment of _Clostridium difficile_ associated diarrhea and …
Matched Mixtures name: … Vancomycin Hydrochloride ... Vancomycin Hydrochloride ... Vancomycin Hydrochloride …
Matched Salts name: … Vancomycin hydrochloride …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Alimentary Tract and Metabolism …
Matched Products: … Vancomycin Hydrochloride ... Vancomycin Hydrocloride ... Vancomycin hydrochloride …
Gadopentetic acid
A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Approved
Matched Synonyms: … Acide gadopentetique ... Gadopentetic acid ... Acidum gadopenteticum …
Matched Name: … Gadopentetic acid …
Matched Description: … acid), that is given to enhance the image in cranial and spinal MRIs. ... A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... gadopentetic acid …
Matched Products: … ACIDO GADOPENTETICO SANOCHEMIA PHARMAZEUTIKA …
Matched Name: … Gadopentetic acid …
Matched Description: … acid), that is given to enhance the image in cranial and spinal MRIs. ... A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... gadopentetic acid …
Matched Products: … ACIDO GADOPENTETICO SANOCHEMIA PHARMAZEUTIKA …
Mupirocin
Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism Pseudomonas fluorescens, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative...
Approved
Investigational
Vet approved
Matched Synonyms: … Pseudomonic acid ... Pseudomonic acid A ... ,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid …
Matched Iupac: … 2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid …
Matched Description: … Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique ... and traumatic skin lesions due to secondary skin infections caused by _S. aureus_ and _S. pyogenes_. ... chemical structure and mode of action apart from other antibiotic agents. …
Matched Mixtures name: … Pre and Post Sx Pouch …
Matched Salts name: … Mupirocin calcium …
Matched Categories: … Fatty Acids …
Matched Products: … Mupirocin Calcium ... MUPIROCIN CALCIUM …
Matched Iupac: … 2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid …
Matched Description: … Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique ... and traumatic skin lesions due to secondary skin infections caused by _S. aureus_ and _S. pyogenes_. ... chemical structure and mode of action apart from other antibiotic agents. …
Matched Mixtures name: … Pre and Post Sx Pouch …
Matched Salts name: … Mupirocin calcium …
Matched Categories: … Fatty Acids …
Matched Products: … Mupirocin Calcium ... MUPIROCIN CALCIUM …
Stearic acid
Stearic acid (IUPAC systematic name: octadecanoic acid) is one of the useful types of saturated fatty acids that comes from many animal and vegetable fats and oils. It is a waxy solid.
Approved
Experimental
Matched Synonyms: … Acide stéarique ... Stearic acid ... Octadecoic acid …
Matched Name: … Stearic acid …
Matched Iupac: … octadecanoic acid …
Matched Description: … acids that comes from many animal and vegetable fats and oils. ... Stearic acid (IUPAC systematic name: octadecanoic acid) is one of the useful types of saturated fatty …
Matched Categories: … Fatty Acids ... Stearic Acids …
Matched Name: … Stearic acid …
Matched Iupac: … octadecanoic acid …
Matched Description: … acids that comes from many animal and vegetable fats and oils. ... Stearic acid (IUPAC systematic name: octadecanoic acid) is one of the useful types of saturated fatty …
Matched Categories: … Fatty Acids ... Stearic Acids …
Pipemidic acid
Experimental
Matched Synonyms: … Pipemidic acid ... acido pipemidico …
Matched Name: … Pipemidic acid …
Matched Iupac: … 8-ethyl-5-oxo-2-(piperazin-1-yl)-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxylic acid …
Matched Salts name: … Pipemidic acid trihydrate …
Matched Categories: … Acids, Heterocyclic ... pipemidic acid ... Nicotinic Acids …
Matched Products: … ACIDO PIPEMIDICO EG ... ACIDO PIPEMIDICO AUROBINDO ... ACIDO PIPEMIDICO DR. REDDY'S …
Matched Name: … Pipemidic acid …
Matched Iupac: … 8-ethyl-5-oxo-2-(piperazin-1-yl)-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxylic acid …
Matched Salts name: … Pipemidic acid trihydrate …
Matched Categories: … Acids, Heterocyclic ... pipemidic acid ... Nicotinic Acids …
Matched Products: … ACIDO PIPEMIDICO EG ... ACIDO PIPEMIDICO AUROBINDO ... ACIDO PIPEMIDICO DR. REDDY'S …
Amantadine
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and...
Approved
Matched Description: … It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic ... effects in movement disorders are not well understood but probably reflect an increase in synthesis and …
Matched Salts name: … Amantadine hydrochloride …
Matched Products: … Amantadine Hydrochloride ... Amantadine hydrochloride ... Pdp-amantadine Hydrochloride Syrup …
Matched Salts name: … Amantadine hydrochloride …
Matched Products: … Amantadine Hydrochloride ... Amantadine hydrochloride ... Pdp-amantadine Hydrochloride Syrup …
Displaying drugs 551 - 575 of 2701 in total