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Displaying drugs 576 - 600 of 655 in total
Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States.
Investigational
Matched Description: … Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of …
Matched Categories: … Calcium-Regulating Hormones and Agents …
Remogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.
Investigational
Matched Description: … Mellitus and Diabetes Mellitus, Type 2. ... Remogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes …
Matched Categories: … Sodium-Glucose Transporter 2 Inhibitors …
Experimental
Matched Salts name: … Vinbarbital sodium
Matched Categories: … Hypnotics and Sedatives …
Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation.
Investigational
Matched Categories: … Sodium Channel Blockers …
Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide,...
Investigational
Matched Description: … However it inhibits taurocholate uptake only in the absence of sodium ions. ... transporter, by the loop diuretic bumetanide, by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) and ... are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid
Matched Categories: … Alimentary Tract and Metabolism …
Experimental
Matched Salts name: … Enibomal sodium
An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. [PubChem]
Experimental
Matched Iupac: … 9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
Matched Categories: … Drugs for Acid Related Disorders ... Alimentary Tract and Metabolism ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Experimental
Matched Iupac: … 6-fluoro-2-{2'-fluoro-[1,1'-biphenyl]-4-yl}-3-methylquinoline-4-carboxylic acid
Matched Salts name: … Brequinar sodium
Omapatrilat is an investigational drug that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in urine, dilating blood vessels, and reducing preload and ventricular remodeling. This drug from BMS was not approved by the FDA due...
Investigational
Matched Iupac: … -oxo-4-[(2S)-3-phenyl-2-sulfanylpropanamido]-octahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid
Matched Description: … The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in urine, dilating ... blood vessels, and reducing preload and ventricular remodeling. ... Omapatrilat is an investigational drug that inhibits both neutral endopeptidase (NEP) and angiotensin …
Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confers the risk for hypokalemia.
Withdrawn
Matched Description: … Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. ... It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium
Investigational
Volixibat, also known as SHP626 or LUM002, is an investigational drug that will potentially be used for the treatment of Non-Alcoholic Steatohepatitis (NASH). If approved for use, it will be the first available agent for the treatment of NASH. Volixibat is a selective inhibitor of the apical sodium-dependent bile acid...
Experimental
Investigational
Matched Iupac: … tetrahydro-1lambda6-benzothiepin-5-yl]phenyl}carbamoyl)amino]-3,5-dihydroxyoxan-2-yl]methoxy}sulfonic acid
Matched Description: … Volixibat is a selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT), a transmembrane ... Also known as the ileal bile acid transporter (IBAT), ASBT is primarily responsible for the enterohepatic ... recirculation of bile acids and ultimately for hepatic lipid and glucose metabolism [A32120]. …
Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups.
Investigational
Matched Description: … It is a lysine-based dendrimer with naphthalene disulfonic acid surface groups. ... Astodrimer has been used in trials studying the treatment and prevention of Bacterial Vaginosis. …
Matched Salts name: … Astodrimer Sodium
Matched Categories: … Amino Acids, Peptides, and Proteins …
A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Withdrawn
Matched Categories: … methyclothiazide and potassium ... Sodium Chloride Symporter Inhibitors …
Experimental
Matched Iupac: … 4-hydroxy-12-oxo-12H-10-oxa-1,5-diazatetraphene-2-carboxylic acid
Matched Salts name: … Pirenoxine sodium
Flomoxef has been used in trials studying the treatment of Urinary Tract Infection.
Investigational
Matched Iupac: … 1,2,3,4-tetrazol-5-yl]sulfanyl}methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Matched Salts name: … Flomoxef Sodium
Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic.
Investigational
Matched Salts name: … Danoprevir sodium
Matched Categories: … Amino Acids, Peptides, and Proteins …
Bevasiranib is a small interfering RNA (siRNA) targeting vascular endothelial growth factor A (VEGF-A).
Investigational
Matched Salts name: … Bevasiranib sodium
Matched Categories: … Nucleic Acid Probes ... Nucleic Acids, Nucleotides, and Nucleosides …
MLN8054 has been used in trials studying the treatment of Colon Neoplasm, Breast Neoplasm, Bladder Neoplasm, Pancreatic Neoplasm, and Advanced Malignancies.
Investigational
Matched Iupac: … difluorophenyl)-3,5,9-triazatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),2,4,6,9,12,14-heptaen-4-yl]amino}benzoic acid
Matched Description: … trials studying the treatment of Colon Neoplasm, Breast Neoplasm, Bladder Neoplasm, Pancreatic Neoplasm, and
Matched Salts name: … MLN8054 sodium
Oglemilast has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive.
Investigational
Matched Salts name: … Oglemilast Sodium
Ecabet is a prescription eye drop for the treatment of dry eye syndrome. Ecabet represents a new class of molecules that increases the quantity and quality of mucin produced by conjunctival goblet cells and corneal epithelia. Mucin is a glycoprotein component of tear film that lubricates while retarding moisture loss...
Investigational
Matched Iupac: … ,10aR)-1,4a-dimethyl-7-(propan-2-yl)-6-sulfo-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
Matched Description: … by conjunctival goblet cells and corneal epithelia. ... Ecabet represents a new class of molecules that increases the quantity and quality of mucin produced ... Ecabet is currently marketed in Japan as an oral agent for treatment of gastric ulcers and gastritis. …
Matched Salts name: … Ecabet sodium
Investigational
Matched Iupac: … 5-methyl-2-(piperazin-1-yl)benzene-1-sulfonic acid
Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.
Investigational
Matched Iupac: … 3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl]propanoic acid
Matched Description: … Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and
T900607 has been used in trials studying the treatment of Liver Cancer and Gastric Cancer.
Investigational
Matched Description: … T900607 has been used in trials studying the treatment of Liver Cancer and Gastric Cancer. …
Matched Salts name: … T 900607 Sodium
Displaying drugs 576 - 600 of 655 in total