Displaying drugs 576 - 600 of 15249 in total
Moxidectin
Moxidectin is a potent, broad-spectrum endectocide (antiparasitic that is active against endo- and ecto-parasites) with activity against nematodes, insects, and acari. It was first used in cattle followed by an approved use in general animals. It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of...
Approved
Investigational
Vet approved
Matched Iupac: … (1'R,2R,4E,4'S,5S,6S,8'R,10'E,13'R,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-4-(methoxyimino)-5,11' ... ,13',22'-tetramethyl-6-(4-methylpent-2-en-2-yl)-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^ …
Matched Description: … It was first used in cattle followed by an approved use in general animals. ... [A33385] Moxidectin was developed by Medicines Development for Global Health and FDA approved in June ... Moxidectin differs by the absence of a disaccharide moiety on carbon 13, a substituted olefinic side …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Description: … It was first used in cattle followed by an approved use in general animals. ... [A33385] Moxidectin was developed by Medicines Development for Global Health and FDA approved in June ... Moxidectin differs by the absence of a disaccharide moiety on carbon 13, a substituted olefinic side …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Racemethionine
A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers.
Approved
Experimental
Matched Iupac: … 2-amino-4-(methylsulfanyl)butanoic acid …
Matched Description: … A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers. …
Matched Mixtures name: … Extra Once A Day ... A/o-26 - Caplet ... Maximum Once A Day …
Matched Description: … A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers. …
Matched Mixtures name: … Extra Once A Day ... A/o-26 - Caplet ... Maximum Once A Day …
Simeprevir
Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United...
Approved
Matched Iupac: … -2-yl]quinolin-4-yl}oxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0^{4,6}]octadec-7-ene-4-carboxamide ... (1R,4R,6R,7Z,15R,17R)-N-(cyclopropanesulfonyl)-17-({7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol …
Matched Description: … Simeprevir was approved by the FDA in November 2014 and is marketed under the brand name Olysio as oral ... Simeprevir is also used in treatment of HCV genotype 4 patients with or without cirrhosis and is taken ... Inhibiting HCV NS3/4A protease in a potent and highly specific manner, simeprevir is a direct-acting …
Matched Description: … Simeprevir was approved by the FDA in November 2014 and is marketed under the brand name Olysio as oral ... Simeprevir is also used in treatment of HCV genotype 4 patients with or without cirrhosis and is taken ... Inhibiting HCV NS3/4A protease in a potent and highly specific manner, simeprevir is a direct-acting …
Human immunoglobulin G
Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population....
Approved
Investigational
Matched Description: … Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human ... IgG subclasses are fully represented in the following proportions: 70.3% IgG1, 24.7% IgG2, 3.1% IgG3, ... IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders …
Matched Products: … GENIVIG HUMAN IMMUNGLOBULIN (PH 4) 5 G/100 ML IV INFUZYON ICIN COZELTI ICEREN FLAKON, 1 ADET …
Matched Products: … GENIVIG HUMAN IMMUNGLOBULIN (PH 4) 5 G/100 ML IV INFUZYON ICIN COZELTI ICEREN FLAKON, 1 ADET …
Colchicine
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events....
Approved
Matched Description: … [A183611] Its use was first approved by the FDA in 1961. ... Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum ... [L47591] It has also been investigated in other inflammatory and fibrotic conditions.[A183602] …
Azadirachta indica leaf
Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. …
Benfotiamine
Benfotiamine has been investigated for the treatment and prevention of Diabetic Nephropathy and Diabetes Mellitus, Type 2.
Approved
Experimental
Matched Iupac: … {[(3Z)-4-{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamido}-3-[(Z)-benzoylsulfanyl]pent-3-en-1-yl] …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Trichloroethylene
Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic and as an inhaled obstetrical analgesic. Environmental exposure,...
Approved
Matched Description: … It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic ... Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the ... Environmental exposure, particularly groundwater and drinking water contamination from industrial discharge, is a …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Brexucabtagene autoleucel
Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib and acalabrutinib, the prognosis for MCL patients remains poor and those that relapse...
Approved
Matched Description: … Brexucabtagene autoleucel was granted accelerated approval for the treatment of relapsed and refractory MCL by ... method of T cell enrichment that decreases the prevalence of CD19-expressing tumour cells in the CAR ... These therapies differ in manufacturing methodology, viral vector, chimeric antigen choice, and the internal …
Matched Categories: … Antineoplastic cell and gene therapy …
Matched Categories: … Antineoplastic cell and gene therapy …
Melphalan flufenamide
Melphalan flufenamide, also known as melflufen or J1, is a prodrug of melphalan.[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. In vitro models show that melphalan is 10 to hundreds of times more potent than melphalan. The increased...
Approved
Withdrawn
Matched Iupac: … ethyl (2S)-2-[(2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanamido]-3-(4-fluorophenyl)propanoate …
Matched Description: … It has since been withdrawn from the market in the wake of the phase 3 OCEAN trial which showed a decrease ... to the active metabolite by aminopeptidases. ... or refractory multiple myeloma who have attempted at least 4 lines of therapy already. …
Matched Description: … It has since been withdrawn from the market in the wake of the phase 3 OCEAN trial which showed a decrease ... to the active metabolite by aminopeptidases. ... or refractory multiple myeloma who have attempted at least 4 lines of therapy already. …
Tyropanoic acid
Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones under the trade names include Bilopaque, Lumopaque, Tyropaque, and Bilopac. The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in bones, which results in a visible image .
Approved
Matched Description: … bones, which results in a visible image [L1608]. ... Tyropanoic acid is a radiocontrast agent used in cholecystography, the X-ray diagnosis of gallstones ... The molecule contains three heavy iodine atoms which obstruct X-rays in the same way as the calcium in …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Articaine
Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.
Approved
Matched Iupac: … methyl 4-methyl-3-[2-(propylamino)propanamido]thiophene-2-carboxylate …
Matched Description: … Articaine is a dental local anesthetic. ... Articaine is widely used around the world and is the most popular local anesthetic in many European countries …
Matched Mixtures name: … ARTINIBSA 4% WITH EPINEPHRINE 1 : 200000 ... ARTINIBSA 4% WITH EPINEPHRINE 1 : 100000 ... ARTHEEK(R) ARTICAINA AL 4% CON EPINEFRINA 1:100.000 …
Matched Description: … Articaine is a dental local anesthetic. ... Articaine is widely used around the world and is the most popular local anesthetic in many European countries …
Matched Mixtures name: … ARTINIBSA 4% WITH EPINEPHRINE 1 : 200000 ... ARTINIBSA 4% WITH EPINEPHRINE 1 : 100000 ... ARTHEEK(R) ARTICAINA AL 4% CON EPINEFRINA 1:100.000 …
Belzutifan
Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau (VHL) disease-associated cancers. The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a key player in the growth of certain cancers. Initially considered to be undruggable,...
Approved
Investigational
Matched Iupac: … 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methanesulfonyl-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile …
Matched Description: … a spin-off company named Peloton Pharmaceuticals (which itself was eventually acquired by Merck in 2019 ... Center as a key player in the growth of certain cancers. ... [L35995] The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical …
Matched Description: … a spin-off company named Peloton Pharmaceuticals (which itself was eventually acquired by Merck in 2019 ... Center as a key player in the growth of certain cancers. ... [L35995] The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical …
Peginterferon beta-1a
Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of...
Approved
Matched Description: … It was originally approved by the FDA in 2014 for subcutaneous use, and was approved for intramuscular ... Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system ... occur more frequently in women than in men. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Ledipasvir
Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Iupac: … methyl N-[(2S)-1-[(6S)-6-[4-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl …
Matched Description: … Approved in October 2014 by the FDA, Harvoni is indicated for the treatment of HCV genotypes 1, 4, 5, ... option in combination with [sofosbuvir] for the treatment of HCV genotypes 1a, 1b, 4, 5, and 6 [L852 ... In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases …
Matched Description: … Approved in October 2014 by the FDA, Harvoni is indicated for the treatment of HCV genotypes 1, 4, 5, ... option in combination with [sofosbuvir] for the treatment of HCV genotypes 1a, 1b, 4, 5, and 6 [L852 ... In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases …
Trofinetide
Trofinetide is a novel synthetic analog of glypromate, also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 (IGF-1). Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[L45718,L45748] which is an X-linked...
Approved
Investigational
Matched Description: … ), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor ... L45718,L45748] which is an X-linked neurodevelopmental disorder characterized by a range of cognitive ... Trofinetide is a novel synthetic analog of [glypromate], also known as glycine–proline–glutamate (GPE …
Calcipotriol
Calcipotriol (INN) or calcipotriene (USAN) is a sythetic derivative of calcitriol or Vitamin D.
Approved
Matched Iupac: … ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol ... -[(1R,3aS,4E,7aR)-1-[(2R,3E,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4- …
Matched Description: … Calcipotriol (INN) or calcipotriene (USAN) is a sythetic derivative of calcitriol or Vitamin D. …
Matched Mixtures name: … Calcipotriene 0.005% / Niacinamide 4% …
Matched Description: … Calcipotriol (INN) or calcipotriene (USAN) is a sythetic derivative of calcitriol or Vitamin D. …
Matched Mixtures name: … Calcipotriene 0.005% / Niacinamide 4% …
Teicoplanin
Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation of side chains attached to their β-D-glucosamine...
Approved
Investigational
Matched Description: … All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation ... teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). ... Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named …
Technetium Tc-99m disofenin
Technetium Tc-99m disofenin is a radiopharmaceutical agent used in hepatobiliary imaging for diagnostic purposes. It is well suited for both planar and single photon tomographic scintigraphy to quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in the hepatobliary system. It is available as...
Approved
Matched Description: … It is available as an intravenous injection in a preparation kit under the name Hepatolite. ... Technetium Tc-99m disofenin is a radiopharmaceutical agent used in hepatobiliary imaging for diagnostic ... quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Human vaccinia virus immune globulin
Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody [FDA Label, A33814]. The IgG fraction is purified by the anion-exchange column chromatography...
Approved
Matched Description: … Nevertheless, VIG by virtue of the way it is produced is a poorly characterized and highly variable human ... product that is only available in very limited quantities - all factors that may intervene with its ... The IgG fraction is purified by the anion-exchange column chromatography method and the solution is solvent …
Gadoversetamide
Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.
Approved
Investigational
Matched Description: … Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast ... agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Meglumine
Approved
Matched Salts cas: … 35564-86-4 …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Nonacog beta pegol
Nonacog beta pegol is a recombinant coagulation factor IX derivative. It is produced without animal-derived materials and with an attached 40kDa polyethylene glycol (PEG) molecule for peptide activation by a site-directed glycoPEGylation. Once activated, the activation molecule with PEG is cleaved to leave the activated factor IX (Factor IXa). Nonacog...
Approved
Investigational
Matched Description: … a site-directed glycoPEGylation. ... Nonacog beta pegol is a recombinant coagulation factor IX derivative. ... [A31496] Nonacog beta pegol was developed by Novo Nordisk and received its first global approval by the …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Diiodohydroxyquinoline
Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products.
Approved
Matched Description: … used in the treatment of amoebiasis. ... Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be ... Iodoquinol is not currently available in any FDA-approved products. …
Matched Mixtures name: … Alcortin A ... Alcortin A …
Matched Mixtures name: … Alcortin A ... Alcortin A …
Ropivacaine
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Approved
Matched Description: … Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin ... It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the …
Displaying drugs 576 - 600 of 15249 in total