Displaying drugs 5976 - 6000 of 8282 in total
GSK-923295
GSK-923295 is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), and the third novel drug candidate to arise from Cytokinetics' broad strategic alliance with GlaxoSmithKline (GSK). GSK-923295 demonstrated a broad spectrum of activity against a range of human tumor xenografts grown in nude mice, including models of...
Investigational
Matched Description: … GSK-923295 demonstrated a broad spectrum of activity against a range of human tumor xenografts grown ... in nude mice, including models of colon, breast, ovarian, lung and other tumors. ... GSK-923295 is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E …
Ellagic acid
Ellagic acid is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. In pomegranates, there are several therapeutic compounds but ellagic acid is the most active and abundant. Ellagic acid is also present in vegetables. Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase...
Investigational
Matched Description: … of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar ... Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase 2 trial), ... protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement …
Epofolate
Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target folate receptor expressing cancer cells. In Phase I/IIa pharmacokinetic and safety studies epofolate was generally tolerable and toxicities known to...
Investigational
Matched Description: … Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. ... Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to ... Antitumor activity was not demonstrated and further development of BMS-753493 has been discontinued. …
Piclidenoson
CF 101 (known generically as IB-MECA) is an anti-inflammatory drug for rheumatoid arthritis patients. Its novel mechanism of action relies on antagonism of adenoside A3 receptors.
CF101 is supplied as an oral drug and has an excellent safety profile. It is also being considered for the treatment of other autoimmune-inflammatory...
Investigational
Matched Description: … Its novel mechanism of action relies on antagonism of adenoside A3 receptors. ... It is also being considered for the treatment of other autoimmune-inflammatory disorders, such as Crohn's …
G207
G207 is cancer-killing viruses, so-called oncolytic viruses, for the treatment of various forms of cancer developed by MediGene AG. These viruses are specific herpes simplex viruses, or HSVs, generally known as the cause of cold sores. MediGene uses these viruses, however, in a modified and "disarmed" form in order to...
Investigational
Matched Description: … G207 is cancer-killing viruses, so-called oncolytic viruses, for the treatment of various forms of cancer ... These viruses are specific herpes simplex viruses, or HSVs, generally known as the cause of cold sores …
CAM-2029
CAM2029 is a new ready-to-use, long-acting octreotide formulation being developed for the long-term treatment of acromegaly, carcinoid syndrome and vasoactive intestinal peptide (VIP)-producing tumours. CAM2029 was found to provide long-acting release of octreotide resulting in a statistically significant suppression of a clinical biomarker insulin-like growth factor 1 (IGF-1) over the...
Investigational
Matched Description: … a new ready-to-use, long-acting octreotide formulation being developed for the long-term treatment of ... CAM2029 was found to provide long-acting release of octreotide resulting in a statistically significant ... suppression of a clinical biomarker insulin-like growth factor 1 (IGF-1) over the target one-month therapeutic …
Seliciclib
R-roscovitine (Seliciclib or CYC202) is a cyclin-dependent kinase (CDK) inhibitor that preferentially inhibits multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase of treated cells. Developed by Cyclacel, seliciclib is being researched for the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex...
Investigational
Matched Description: … Developed by Cyclacel, seliciclib is being researched for the treatment of non-small cell lung cancer ... (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation ... preferentially inhibits multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase of …
Etesevimab
Etesevimab (LY-CoV016, also known as JS016) is a fully human and recombinant monoclonal antibody that targets the SARS-CoV-2 surface spike protein receptor binding domain.[L16651,L16661] Under the EUA granted in February 2021, etesevimab is used in combination with bamlanivimab to treat mild to moderate COVID-19 in adults and pediatric patients who...
Investigational
Matched Description: … [L40174] The EUA currently allows bamlanivimab and etesevimab for post-exposure prophylaxis of COVID- …
Dithioerythritol
A compound that, along with its isomer, Cleland's reagent (dithiothreitol), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups. [PubChem]
Experimental
Matched Description: … compound that, along with its isomer, Cleland's reagent (dithiothreitol), is used for the protection of ... sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl …
DDP-200
DDP200 is developed by Dynogen for the treatment of non-incontinent form of overactive bladder (OAB) with particular focus on both male and female patients with urinary frequency, urinary urgency and nocturia.
Investigational
Matched Description: … DDP200 is developed by Dynogen for the treatment of non-incontinent form of overactive bladder (OAB) …
Ginkgolide A
Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders.
Nutraceutical
Matched Description: … Shows potential in a wide variety of inflammatory and immunological disorders. ... Ginkgolide A is a highly active PAF antagonist cage molecule that is isolated from the leaves of the …
Entinostat
Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.
Investigational
Matched Description: … Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy. ... Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers …
Imolamine
Imolamine is a compound with a molecular weight of 260.33 g/mol with the formula diethyl[2-{5-imino-3-phenyl-4,5-dihydro-1,2,3-oxadiazol,-4-yl)ethyl]amine. It is developed under the brand name Coremax by Novartis consumer health SA.
Investigational
Matched Description: … Imolamine is a compound with a molecular weight of 260.33 g/mol with the formula diethyl[2-{5-imino-3 …
Farletuzumab
Farletuzumab (MORAb-003) is a fully humanized monoclonal antibody against the folate receptor alpha, for the potential treatment of epithelial ovarian cancer.
Investigational
Matched Description: … fully humanized monoclonal antibody against the folate receptor alpha, for the potential treatment of …
Sinapic acid
Sinapic acid is a matrix for matrix-assisted laser desorption technique for protein MW determination. It is also a constituent of propolis.
Experimental
Matched Description: … It is also a constituent of propolis. …
Glyceryl monostearate
Glycerol monostearate, commonly known as GMS, is the glycerol ester of stearic acid . It is commonly used as an emulsifier in foods.
Experimental
Matched Description: … Glycerol monostearate, commonly known as GMS, is the glycerol ester of stearic acid . …
Figitumumab
Figitumumab has been used in trials studying the treatment of Sarcoma, Solid Tumor, Breast Cancer, Lung Neoplasms, and Advanced Cancer, among others.
Investigational
Matched Description: … Figitumumab has been used in trials studying the treatment of Sarcoma, Solid Tumor, Breast Cancer, Lung …
Antineoplaston A10
Antineoplaston A10 has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver Cancer, and Kidney Cancer, among others.
Investigational
Matched Description: … Antineoplaston A10 has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, …
Mirogabalin
Mirogabalin has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain.
Investigational
Matched Description: … Mirogabalin has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated …
Triapine
Triapine has been used in trials studying the treatment of Leukemia, Lung Cancer, Kidney Cancer, Prostate Cancer, and Pancreatic Cancer, among others.
Investigational
Matched Description: … Triapine has been used in trials studying the treatment of Leukemia, Lung Cancer, Kidney Cancer, Prostate …
PF-04457845
PF-04457845 is under investigation in Fear Conditioning. PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence.
Investigational
Matched Description: … PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence. …
9-aminocamptothecin
Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal Cancer, and Ovarian Neoplasms, among others.
Investigational
Matched Description: … Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian …
Taladegib
Taladegib has been used in trials studying the treatment of Solid Tumor, COLON CANCER, BREAST CANCER, Advanced Cancer, and Rhabdomyosarcoma, among others.
Investigational
Matched Description: … Taladegib has been used in trials studying the treatment of Solid Tumor, COLON CANCER, BREAST CANCER, …
Fluocinolone
Fluocinolone has been used in trials studying the treatment and prevention of Candida Infection, Oral Lichen Planus, Macular Degeneration, and Choroidal Neovascularization.
Investigational
Matched Description: … Fluocinolone has been used in trials studying the treatment and prevention of Candida Infection, Oral …
AZD-1480
AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.
Investigational
Matched Description: … AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera …
Displaying drugs 5976 - 6000 of 8282 in total