Displaying drugs 6501 - 6525 of 8037 in total
Levophencynonate
Levophencynonate is under investigation in clinical trial NCT02299804 (A Clinical Trial to Evaluate Efficacy and Safety of Levophencynonate Hydrochloride in Patient With Vertigo).
Investigational
Matched Description: … under investigation in clinical trial NCT02299804 (A Clinical Trial to Evaluate Efficacy and Safety of …
4'-Thio-fac
4'-Thio-fac is under investigation in clinical trial NCT02661542 (Study of FF-10502-01 in Patients With Advanced Solid Tumors and Lymphomas).
Investigational
Matched Description: … 4'-Thio-fac is under investigation in clinical trial NCT02661542 (Study of FF-10502-01 in Patients With …
EMB-01
EMB-01 is under investigation in clinical trial NCT03797391 (A Dose Escalation Study of EMB-01 in Participants With Advanced/metastatic Solid Tumors).
Investigational
Matched Description: … EMB-01 is under investigation in clinical trial NCT03797391 (A Dose Escalation Study of EMB-01 in Participants …
Dotinurad
Dotinurad is under investigation in clinical trial NCT03372200 (Febuxostat-controlled, Double-blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout).
Investigational
Matched Description: … investigation in clinical trial NCT03372200 (Febuxostat-controlled, Double-blind, Comparative Study of …
Firsocostat
Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)).
Investigational
Matched Description: … Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of …
Ivuxolimab
Ivuxolimab is under investigation in clinical trial NCT02554812 (A Study of Avelumab in Combination With Other Cancer Immunotherapies in Advanced Malignancies (JAVELIN Medley)).
Investigational
Matched Description: … Ivuxolimab is under investigation in clinical trial NCT02554812 (A Study of Avelumab in Combination With …
Orticumab
Orticumab is under investigation in clinical trial NCT04776629 (A Proof-of-activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors).
Investigational
Matched Description: … Orticumab is under investigation in clinical trial NCT04776629 (A Proof-of-activity Study With Orticumab …
Tividenofusp alfa
Tividenofusp alfa, also known as DNL-310, is a brain-penetrant enzyme replacement therapy being investigated for the treatment of Hunter syndrome.
Investigational
Matched Description: … known as DNL-310, is a brain-penetrant enzyme replacement therapy being investigated for the treatment of …
Aphidicolin
Aphidicolin is an antimitotic and antiviral metabolite of the mould Cephalosporium aphidicola. It inhibits DNA polymerase alpha and blocks DNA replication.[A259157, A259162]
Investigational
Matched Description: … Aphidicolin is an antimitotic and antiviral metabolite of the mould _Cephalosporium aphidicola_. …
TRK-001
TRK-001 is an autologous regulatory T-cell therapy. It is being investigated for the prevention of graft rejection following solid organ transplantation.
Investigational
Matched Description: … It is being investigated for the prevention of graft rejection following solid organ transplantation. …
Antipain
Antipain is a serine/cysteine protease inhibitor originally isolated from various strains of actinomycetes. Early studies investigated the potential for antipain to alter DNA damage and chromosomal aberrations in irradiated cells or those treated with chemical mutagens such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).[A214484, A214487]
Antipain was used in 2010 to obtain a crystal...
Experimental
Matched Description: … Antipain is a serine/cysteine protease inhibitor originally isolated from various strains of actinomycetes ... [A214484, A214487]
Antipain was used in 2010 to obtain a crystal structure of the _Leishmania major ... [A214490] The binding of antipain to OPB has been used in molecular dynamic studies to identify other …
XL820
XL820 is investigated for use/treatment in solid tumors. XL820 is a solid. The proteins that XL820 inhibit include platelet-derived growth factor receptor beta (PDGFR), mast/stem cell growth factor receptor KIT, vascular endothelial growth factor receptor 2, and platelet-derived growth factor receptor alpha, clinically validated targets implicated in a variety of...
Investigational
Matched Description: … XL820 exhibits dose-dependent growth inhibition in models of breast carcinoma, gliomas and leukemia. ... platelet-derived growth factor receptor alpha, clinically validated targets implicated in a variety of …
AMG-131
AMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131...
Investigational
Matched Description: … T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor ... T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos …
Lactobacillus plantarum
Lactobacillus plantarum is a member of Lactobacillus, or lactic acid bacteria, that it is widely used in the food industry as a microbial starter and probiotic microorganism. It is considered to be one of versatile species that carry out fermentative and metabolic processes, while exhibiting an antagonistic activity against pathogenic...
Investigational
Matched Description: … *Lactobacillus plantarum* is a member of Lactobacillus, or lactic acid bacteria, that it is widely used ... It is considered to be one of versatile species that carry out fermentative and metabolic processes, …
H3B-8800
H3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine . It offers the benefit of preferentially killing spliceosome-mutant cancer cells whereas other splicesome inhibitors, such as the pladienolide analogue E7107, show no such preferential targeting . H3B-8800 was granted orphan drug status by the FDA in August 2017 and...
Investigational
Matched Description: … It offers the benefit of preferentially killing spliceosome-mutant cancer cells whereas other splicesome ... was granted orphan drug status by the FDA in August 2017 and is in clinical trials for the treatment of …
SCB-2019
SCB-2019 is a recombinant trimeric S protein subunit vaccine candidate being investigated against COVID-19. This vaccine candidate resembles the native trimeric viral spike and is produced through mammalian cell-culture.
The vaccine was developed and tested by Clover Biopharmaceuticals AUS Pty Ltd.. As of June 2020, the company is pursuing a...
Investigational
Matched Description: … ) to test the safety and immunogenicity of the vaccine. ... As of June 2020, the company is pursuing a randomized, double blind, placebo controlled study (NCT04405908 …
CoVac-1
Sponsored by the University Hospital Tuebingen in Germany, CoVac-1 is a multi-peptide COVID-19 vaccine candidate created from HLA class I and HLA-DR T-cell epitopes of the S-protein . It is being investigated in the clinical trial NCT04546841 (Safety and Immunogenicity Trial of Multi-peptide Vaccination to Prevent COVID-19 Infection in Adults...
Investigational
Matched Description: … 1 is a multi-peptide COVID-19 vaccine candidate created from HLA class I and HLA-DR T-cell epitopes of ... It is being investigated in the clinical trial NCT04546841 (Safety and Immunogenicity Trial of Multi-peptide …
MVA-SARS-2-S
MVA-SARS-2-S is a COVID-19 vaccine candidate that contains a Modified Vaccinia Virus Ankara (MVA) vector expressing the SARS-CoV-2 spike protein . MVA is a highly attenuated poxvirus vector that has a high-level of biological safety due to its quality of being a non-replicating virus in mammalian hosts and is used...
Investigational
Matched Description: … MVA is a highly attenuated poxvirus vector[A226603] that has a high-level of biological safety due to ... its quality of being a non-replicating virus in mammalian hosts[L30458] and is used to develop vaccines …
Dihydroxyacetone phosphate
Dihydroxyacetone phosphate is an important intermediate in lipid biosynthesis and in glycolysis. Dihydroxyacetone phosphate has been investigated for the treatment of Lymphoma, Large-Cell, Diffuse.
Investigational
Matched Description: … Dihydroxyacetone phosphate has been investigated for the treatment of Lymphoma, Large-Cell, Diffuse. …
SGS518
SGS518, a novel antagonist for the 5HT6 subtype of the serotonin receptor, is being developed as a treatment for Cognitive Impairment Associated with Schizophrenia (CIAS).
Investigational
Matched Description: … SGS518, a novel antagonist for the 5HT6 subtype of the serotonin receptor, is being developed as a treatment …
SSR-126517E
SSR-126517E is a second generation synthetic pentasaccharide that binds antithrombin with such high affinity that it assumes a plasma half-life of 80 hours.
Investigational
Matched Description: … pentasaccharide that binds antithrombin with such high affinity that it assumes a plasma half-life of …
Clenoliximab
Clenoliximab is a chimeric monoclonal antibody from Macaca irus against CD4 which acts as an immunomodulator. It has investigated for the treatment of rheumatoid arthritis.
Investigational
Matched Description: … It has investigated for the treatment of rheumatoid arthritis. …
Psilocybin
Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA.
Investigational
Matched Description: … Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. …
Mirodenafil
Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction.
Investigational
Matched Description: … Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic …
Fimepinostat
Fimepinostat (CUDC-907) has been used in trials studying the treatment of lymphoma, solid tumors, breast cancer, multiple myeloma, and NUT midline carcinoma, among others.
Investigational
Matched Description: … Fimepinostat (CUDC-907) has been used in trials studying the treatment of lymphoma, solid tumors, breast …
Displaying drugs 6501 - 6525 of 8037 in total