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Displaying drugs 701 - 725 of 853 in total
Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an intraurethral suppository, for the treatment of erectile dysfunction, and it is used in men for whom oral treatment...
Approved
Investigational
Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). Janus kinases are intracellular enzymes involved in transduction pathways that regulate hematopoiesis and immune cell function. The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of...
Approved
Investigational
Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and S1P3 receptors. S1P receptors are membrane-derived lysophospholipid signaling molecules that are involved in the sequestration of circulating peripheral lymphocytes in lymph nodes. Therefore, S1P receptor modulators like etrasimod...
Approved
Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating earlier developed MEK inhibitors were underwhelming. However,...
Approved
Investigational
Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAA receptors. Unlike other more common GABAA positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and extrasynaptic GABAA conductance due to binding to a non-benzodiazepine site on the receptor.[A260776,A260786] Zuranolone was...
Approved
Experimental
Zinc oxide is an inorganic compound used in a number of manufacturing processes. It can be found in rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and first-aid tapes. It occurs naturally as the mineral zincite, but most zinc oxide is produced...
Approved
Matched Products: … Ursa Major Force Field SPF 30 …
Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Approved
Matched Mixtures name: … Major Night Time Multi Symptom cold and flu relief …
Investigational
Matched Synonyms: … Human major histocompatibility complex (MHC) non-restricted T-cell line 104 …
AAV9/MFSD8 is a gene therapy developed by Neurogene Inc. It is an adeno-associated virus serotype 9 (AAV9) vector with an engineered transgene encoding the human CLN7/MFSD8 gene for expression of active human major facilitator superfamily domain containing 8. It was investigated for the treatment of neuronal ceroid lipofuscinosis type 7.
Investigational
Matched Synonyms: … vector with engineered transgene encoding the human CLN7/MFSD8 gene for expression of active human major
Matched Description: … vector with an engineered transgene encoding the human CLN7/MFSD8 gene for expression of active human major
Lanicemine has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment Resistant Major Depressive Disorder.
Investigational
Matched Description: … Disorder, and Treatment Resistant Major Depressive Disorder. ... Lanicemine has been used in trials studying the treatment and basic science of Depression, Major Depressive …
Toloxatone is an antidepressant agent, the first ever use of which was in France, 1984. It acts as a selective and reversible inhibitor of monoamine oxidase-A (MOA) .
Experimental
Tedatioxetine has been used in trials studying the treatment of Major Depressive Disorder.
Investigational
Matched Description: … Tedatioxetine has been used in trials studying the treatment of Major Depressive Disorder. …
Farampator is under investigation in clinical trial NCT00113022 (Org 24448 to Treat Major Depression).
Investigational
Matched Description: … Farampator is under investigation in clinical trial NCT00113022 (Org 24448 to Treat Major Depression) …
Perflubron (Oxygent) is being developed as an intravascular oxygen carrier designed to augment oxygen delivery in surgical patients.
Investigational
The pipecolinate derivative biricodar (VX-710) is a clinically applicable modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1).
Investigational
Ketodarolutamide, a nonsteroidal antiandrogen (NSAA), is the major active metabolite of darolutamide.
Experimental
Matched Description: … Ketodarolutamide, a nonsteroidal antiandrogen (NSAA), is the major active metabolite of [darolutamide …
ANC-501 is under investigation in clinical trial NCT05439603 (ANC-501 in the Treatment of Adults With Major Depressive Disorder).
Investigational
Matched Description: … ANC-501 is under investigation in clinical trial NCT05439603 (ANC-501 in the Treatment of Adults With Major
Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.
Investigational
Matched Description: … Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major. …
Decoglurant has been used in trials studying the treatment of Major Depressive Disorder.
Investigational
Matched Description: … Decoglurant has been used in trials studying the treatment of Major Depressive Disorder. …
ACP-104, or N-desmethylclozapine, is the major metabolite of clozapine, and is being developed by ACADIA as a novel, stand-alone therapy for schizophrenia. It combines an atypical antipsychotic efficacy profile with the added potential benefit of enhanced cognition, thereby addressing one of the major challenges in treating schizophrenia today.
Investigational
Matched Description: … ACP-104, or N-desmethylclozapine, is the major metabolite of clozapine, and is being developed by ACADIA ... efficacy profile with the added potential benefit of enhanced cognition, thereby addressing one of the major
Mk 0657 has been used in trials studying the treatment of Major Depressive Disorder.
Investigational
Matched Description: … Mk 0657 has been used in trials studying the treatment of Major Depressive Disorder. …
Filorexant has been used in trials studying the prevention and treatment of Migraine, Headache, Polysomnography, Diabetic Neuropathy, Painful, and Major Depressive Disorder, Recurrent.
Investigational
Matched Description: … prevention and treatment of Migraine, Headache, Polysomnography, Diabetic Neuropathy, Painful, and Major
CP-601,927 has been used in trials studying the basic science and treatment of Major Depressive Disorder.
Investigational
Matched Description: … CP-601,927 has been used in trials studying the basic science and treatment of Major Depressive Disorder …
DU125530 is under investigation in clinical trial NCT01119430 (Fluoxetine Versus Fluoxetine Plus DU125530 in Major Depressive Disorder).
Investigational
Matched Description: … is under investigation in clinical trial NCT01119430 (Fluoxetine Versus Fluoxetine Plus DU125530 in Major
NSI-189 is under investigation in clinical trial NCT02695472 (Study of NSI-189 for Major Depressive Disorder).
Investigational
Matched Description: … NSI-189 is under investigation in clinical trial NCT02695472 (Study of NSI-189 for Major Depressive Disorder …
Displaying drugs 701 - 725 of 853 in total