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Displaying drugs 51 - 75 of 359 in total

Trihexyphenidyl

Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant...
Approved
Matched Description: … Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced ... [A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment …

Methylprednisolone

Methylprednisolone is a prednisolone derivative glucocorticoid with higher potency than prednisone. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was successful in treating COVID-19-associated pneumonia in one patient with...
Approved
Vet approved
Matched Description: … outbreak of COVID-19, low dose methylprednisolone-based therapy was successful in treating COVID-19-associated …
Matched Categories: … Hyperglycemia-Associated Agents ... Sex Hormones and Insulins ... methylprednisolone and antibiotics ... methylprednisolone and antiinfectives ... methylprednisolone and antiinfectives …

Delafloxacin

Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in the treatment of...
Approved
Investigational
Matched Description: … Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and ... basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and ... approved in June 2017 under the trade name Baxdela for use in the treatment of acute bacterial skin and …

Danazol

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Approved
Matched Description: … Danazol has been used in the treatment of endometriosis and some benign breast disorders. ... A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary …
Matched Categories: … Hyperglycemia-Associated Agents ... Antigonadotropins and Similar Agents ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Tramadol

Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered...
Approved
Investigational
Matched Description: … number of pain types including neuropathic pain, post-operative pain, lower back pain, as well as pain associated ... of and response to pain. ... such as [duloxetine] and [venlafaxine]. …
Matched Mixtures name: … Tramadol HCl and Acetaminophen ... Tramadol Hydrochloride and Acetaminophen ... Tramadol Hydrochloride and Acetaminophen …
Matched Categories: … tramadol and celecoxib ... tramadol and paracetamol ... tramadol and dexketoprofen …

Nelarabine

Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease has not responded to or has relapsed following at least two chemotherapy regimens. T-cell acute lymphoblastic...
Approved
Investigational
Matched Description: … , albeit with serious hematological and neurological adverse events. ... treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and ... [L40878] T-cell acute lymphoblastic leukemia and lymphoma are relatively rare T-cells malignancy, with …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Chloramphenicol

An antibiotic first isolated from cultures of Streptomyces venezuelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)...
Approved
Vet approved
Withdrawn
Matched Description: … withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated ... It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. ... It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Ophthalmological and Otological Preparations …

Benserazide

When levodopa is used by itself as a therapy for treating Parkinson's disease, its ubiquitous metabolism into dopamine is responsible for a resultant increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. This can result in a number of side effects like nausea, vomiting,...
Approved
Investigational
Matched Description: … dopamine is responsible for a resultant increase in the levels of circulating dopamine in the blood and ... approved another similar levodopa/dopa decarboxylase inhibitor combination in the form of levodopa and ... particular, although the specific levodopa/benserazide combination is formally approved for use in Canada and …

Telavancin

Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Approved
Matched Description: … MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated ... pneumonia (VAP), and skin and subcutaneous tissue infections among others. ... vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Isoetharine

Isoetharine is a relatively selective beta-2 adrenergic agonist. It is a catechol-like agent. Isoetharine is a fast-acting bronchodilator used for emphysema, bronchitis and asthma.
Approved
Matched Description: … Isoetharine is a fast-acting bronchodilator used for emphysema, bronchitis and asthma.[A330] …

Decitabine

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis.[A215082, A215092] Among treatment options, nucleoside analogues such as...
Approved
Investigational
Matched Description: … and related downstream therapeutic benefits. ... presentation, including neutropenia and thrombocytopenia. ... syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Clobetasone

Clobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.
Approved
Matched Description: … as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and …
Matched Categories: … clobetasone and antiinfectives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Medrysone

Medrysone is a corticosteroid used in ophthalmology.
Approved
Matched Categories: … Hyperglycemia-Associated Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Asciminib

Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein which serves as a driver of CML proliferation in most patients with the disease....
Approved
Investigational
Matched Description: … those that target the active conformation of the kinase domain ([dasatinib], [bosutinib]) and those ... Existing inhibitors of ABL compete at the ATP binding sites of these proteins and can be classified into ... in that it acts as an allosteric inhibitor, binding at the myristoyl pocket of the BCR-ABL1 protein and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Brexanolone

As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like...
Approved
Investigational
Matched Description: … directly associated with PPD like natural fluctuations in the levels of endogenous neuroactive steroids ... provides a new and promising therapy where few existed before [F4066]. ... As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Desogestrel

Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological...
Approved
Matched Description: … family which was largely used in Europe before being approved in the US and Canada. ... Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane ... [A176339] It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent …
Matched Mixtures name: … Desogestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Desogestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Desogestrel and Ethinyl Estradiol …
Matched Categories: … Hyperglycemia-Associated Agents ... desogestrel and estrogen ... desogestrel and ethinylestradiol ... desogestrel and ethinylestradiol ... Genito Urinary System and Sex Hormones …

Dehydrocholic acid

Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid . It has been used for stimulation of biliary lipid secretion. The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
Approved
Investigational
Matched Categories: … Bile Acids and Salts ... Cholagogues and Choleretics …

Prasterone

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. In...
Approved
Investigational
Nutraceutical
Matched Description: … It is also produced in small quantities in the testis and the ovary. ... Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone ... DHEA and DHEAS are readily available in the United States, where they are marketed as over-the-counter …
Matched Categories: … Androgens and Estrogens ... prasterone and estrogen ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Clobetasol propionate

Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the literature in 1974. Clobetasol Propionate was granted FDA approval on 27 December 1985.
Approved
Matched Description: … [L11815] It has demonstrated superior activity compared to [fluocinonide][A190963] and was first described …
Matched Categories: … Hyperglycemia-Associated Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Difluocortolone

Difluocortolone is a potent topical corticosteroid. It is commonly used in dermatology for the reduction of inflammation and itching. It was submitted to the FDA in July 1984 by the pharmaceutical company Schering AG.
Approved
Investigational
Withdrawn
Matched Description: … It is commonly used in dermatology for the reduction of inflammation and itching. …
Matched Categories: … Hyperglycemia-Associated Agents ... diflucortolone and antiseptics ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Clobetasol

Clobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids.
Approved
Experimental
Investigational
Matched Description: … Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids …
Matched Categories: … Hyperglycemia-Associated Agents ... clobetasol and antibiotics ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Oxandrolone

A synthetic hormone with anabolic and androgenic properties.
Approved
Investigational
Matched Description: … A synthetic hormone with anabolic and androgenic properties. …
Matched Categories: … Alimentary Tract and Metabolism ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Valrubicin

Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the doxorubicin, which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Approved
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Methoxamine

An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system.
Approved
Investigational
Matched Categories: … Adrenergic and Dopaminergic Agents …

Gallium citrate Ga-67

Gallium citrate Ga 67 is the citrate salt of the radioisotope gallium Ga 67. Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation, allowing scintigraphic localization. Ga-67 scintigraphy...
Approved
Matched Description: … intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation ... Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble ... Ga-67 scintigraphy (GS) cannot differentiate between tumor and acute inflammation. [NCI Thesaurus] …
Displaying drugs 51 - 75 of 359 in total