Displaying drugs 776 - 800 of 2861 in total
St. John's Wort
Approved
Investigational
Nutraceutical
Matched Synonyms: … Hypoxis hemerocallidea root extract …
Matched Categories: … Herbs and Natural Products …
Matched Categories: … Herbs and Natural Products …
Recombinant human alkaline phosphatase
Investigational
Matched Synonyms: … Human recombinant alkaline phosphatase ... Recombinant human alkaline phosphatase …
Matched Name: … Recombinant human alkaline phosphatase …
Matched Name: … Recombinant human alkaline phosphatase …
Passiflora incarnata flower
Approved
Experimental
Matched Categories: … Herbs and Natural Products ... Hypnotics and Sedatives …
Matched Products: … Passiflore Natura Medica …
Matched Products: … Passiflore Natura Medica …
Col-Treg
Col-Treg is an autologous T-cell therapy comprising type I regulatory T-cells specific for human type II collagen.
Investigational
Matched Name: … Col-Treg …
Matched Description: … Col-Treg is an autologous T-cell therapy comprising type I regulatory T-cells specific for human type …
Matched Description: … Col-Treg is an autologous T-cell therapy comprising type I regulatory T-cells specific for human type …
Hypochlorite
Hypochlorite is an ion composed of chlorine and oxygen with the chemical formula ClO−. Being unstable in the pure form, hypochlorite is most commonly used for bleaching, disinfectation, and water treatment purposes in its salt form, sodium hypochlorite. Hypochlorite is often used as a chemical reagent for chlorination and oxidation...
Approved
Matched Description: … Hypochlorite is an ion composed of chlorine and oxygen with the chemical formula ClO−. ... Being unstable in the pure form, hypochlorite is most commonly used for bleaching, disinfectation, and ... Hypochlorite is often used as a chemical reagent for chlorination and oxidation reactions. …
Matched Categories: … Antiseptics and Disinfectants ... Acids ... Acids, Noncarboxylic …
Matched Products: … AMUKINE MED ... SUPERCLEAN Micro Acid Hypochlorite Disinfectant …
Matched Categories: … Antiseptics and Disinfectants ... Acids ... Acids, Noncarboxylic …
Matched Products: … AMUKINE MED ... SUPERCLEAN Micro Acid Hypochlorite Disinfectant …
Tiaprofenic acid
Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Synonyms: … Tiaprofenic acid ... Acido tiaprofenico ... Acide tiaprofenique …
Matched Name: … Tiaprofenic acid …
Matched Iupac: … 2-(5-benzoylthiophen-2-yl)propanoic acid …
Matched Description: … Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly ... It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Acids, Acyclic ... Fatty Acids ... Carboxylic Acids …
Matched Products: … Teva-tiaprofenic Acid …
Matched Name: … Tiaprofenic acid …
Matched Iupac: … 2-(5-benzoylthiophen-2-yl)propanoic acid …
Matched Description: … Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly ... It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Acids, Acyclic ... Fatty Acids ... Carboxylic Acids …
Matched Products: … Teva-tiaprofenic Acid …
5-phospho-D-arabinohydroxamic acid
Experimental
Matched Synonyms: … (2R,3R,4S)-2,3,4-Trihydroxy-5-(hydroxyamino)-5-oxopentyl dihydrogen phosphate …
Matched Name: … 5-phospho-D-arabinohydroxamic acid …
Matched Iupac: … [(2R,3R,4S)-2,3,4-trihydroxy-4-(hydroxycarbamoyl)butoxy]phosphonic acid …
Matched Name: … 5-phospho-D-arabinohydroxamic acid …
Matched Iupac: … [(2R,3R,4S)-2,3,4-trihydroxy-4-(hydroxycarbamoyl)butoxy]phosphonic acid …
Clopidogrel
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral...
Approved
Matched Description: … Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and ... with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and ... be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and …
Matched Mixtures name: … Clopidogrel/acetylsalicylic Acid Mylan ... Clopidogrel/acetylsalicylic Acid Mylan ... Clopidogrel/acetylsalicylic Acid Mylan …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … CLOPIDOGREL ACINO ... Clopidogrel Acino ... CLOPIDOGREL ACINO PHARMA …
Matched Mixtures name: … Clopidogrel/acetylsalicylic Acid Mylan ... Clopidogrel/acetylsalicylic Acid Mylan ... Clopidogrel/acetylsalicylic Acid Mylan …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … CLOPIDOGREL ACINO ... Clopidogrel Acino ... CLOPIDOGREL ACINO PHARMA …
Celecoxib
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in...
Approved
Investigational
Matched Description: … [A181544] It is used to manage symptoms of various types of arthritis pain and in familial adenomatous ... [A181532] It is marketed by Pfizer under the brand name Celebrex, and was initially granted FDA approval ... selective COX-2 inhibitors (especially celecoxib), have been evaluated as potential cancer chemopreventive and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antineoplastic and Immunomodulating Agents ... tramadol and celecoxib ... amlodipine and celecoxib ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … ACTREL ... CELECOXIB ACINO 100MG ... CELECOXIB ACINO 200MG …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antineoplastic and Immunomodulating Agents ... tramadol and celecoxib ... amlodipine and celecoxib ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … ACTREL ... CELECOXIB ACINO 100MG ... CELECOXIB ACINO 200MG …
Tocilizumab
Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 January 2010 to treat a...
Approved
Matched Description: … [L40164] Subsequently, it was granted approval by Health Canada and the FDA in October [L43697] and December ... Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and ... autoimmune disorders, such as different types of arthritis and cytokine release syndrome. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Actemra ACTPen …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Actemra ACTPen …
Nitric acid
Experimental
Matched Synonyms: … Acido nitrico ... Acide nitrique ... Nitric acid, anhydrous …
Matched Name: … Nitric acid …
Matched Iupac: … nitric acid …
Matched Categories: … Acids ... Acids, Noncarboxylic …
Matched Name: … Nitric acid …
Matched Iupac: … nitric acid …
Matched Categories: … Acids ... Acids, Noncarboxylic …
Pentetic acid
Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes. DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment...
Approved
Matched Synonyms: … Pentetic acid ... Diethylene triamine pentaacetic acid ... Diethylenetriamine pentaacetic acid …
Matched Name: … Pentetic acid …
Matched Iupac: … 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetic acid …
Matched Description: … acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ... DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment ... [L2242] DPTA was developed by the pharmaceutical company CIS US and FDA approved on April 14, 2004. …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Lead Chelator ... Lead Chelating Activity …
Matched Products: … Pentetic Acid …
Matched Name: … Pentetic acid …
Matched Iupac: … 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetic acid …
Matched Description: … acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ... DTPA, along with its calcium and zinc trisodium salts, are the only FDA approved agents for the treatment ... [L2242] DPTA was developed by the pharmaceutical company CIS US and FDA approved on April 14, 2004. …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Lead Chelator ... Lead Chelating Activity …
Matched Products: … Pentetic Acid …
Pipemidic acid
Experimental
Matched Synonyms: … Pipemidic acid ... acido pipemidico …
Matched Name: … Pipemidic acid …
Matched Iupac: … 8-ethyl-5-oxo-2-(piperazin-1-yl)-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxylic acid …
Matched Salts name: … Pipemidic acid trihydrate …
Matched Categories: … Acids, Heterocyclic ... pipemidic acid ... Nicotinic Acids …
Matched Products: … ACIDO PIPEMIDICO EG ... ACIDO PIPEMIDICO AUROBINDO ... ACIDO PIPEMIDICO DR. REDDY'S …
Matched Name: … Pipemidic acid …
Matched Iupac: … 8-ethyl-5-oxo-2-(piperazin-1-yl)-5H,8H-pyrido[2,3-d]pyrimidine-6-carboxylic acid …
Matched Salts name: … Pipemidic acid trihydrate …
Matched Categories: … Acids, Heterocyclic ... pipemidic acid ... Nicotinic Acids …
Matched Products: … ACIDO PIPEMIDICO EG ... ACIDO PIPEMIDICO AUROBINDO ... ACIDO PIPEMIDICO DR. REDDY'S …
Rumex crispus top
Rumex crispus top allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Rumex crispus flower/leaf/stem extract …
Formic acid
Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. It is commonly used as a preservative and antibacterial agent in livestock feed.
Experimental
Investigational
Matched Synonyms: … Aminic acid ... Formic acid ... Acide formique …
Matched Name: … Formic acid …
Matched Iupac: … formic acid …
Matched Description: … of bee and ant stings. ... It is commonly used as a preservative and antibacterial agent in livestock feed. ... It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids …
Matched Name: … Formic acid …
Matched Iupac: … formic acid …
Matched Description: … of bee and ant stings. ... It is commonly used as a preservative and antibacterial agent in livestock feed. ... It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids …
Isoflurophate
An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)
Approved
Investigational
Withdrawn
Matched Synonyms: … Fluorodiisopropyl phosphate ... Diisopropylfluorophosphoric acid ester …
Matched Description: … Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically …
Matched Description: … Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically …
Hippuric acid
Investigational
Matched Synonyms: … Acido ippurico ... Benzamidoacetic acid ... Benzoylaminoacetic acid …
Matched Name: … Hippuric acid …
Matched Iupac: … 2-(phenylformamido)acetic acid …
Matched Categories: … Benzamides and benzamide derivatives ... Keto Acids ... Acids, Carbocyclic ... Carboxylic Acids …
Matched Name: … Hippuric acid …
Matched Iupac: … 2-(phenylformamido)acetic acid …
Matched Categories: … Benzamides and benzamide derivatives ... Keto Acids ... Acids, Carbocyclic ... Carboxylic Acids …
Nalidixic acid
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
Approved
Investigational
Matched International brands: … Nal-acid …
Matched Synonyms: … Nalidixic acid ... Acido nalidixico ... Acide nalidixique …
Matched Name: … Nalidixic acid …
Matched Iupac: … 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid …
Matched Description: … Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum …
Matched Categories: … nalidixic acid …
Matched Products: … ACIDO NALIDIXICO ... ACIDO NALIDIXICO NOVASOREL ... ACIDO NALIDIXICO SUSPENSION …
Matched Synonyms: … Nalidixic acid ... Acido nalidixico ... Acide nalidixique …
Matched Name: … Nalidixic acid …
Matched Iupac: … 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid …
Matched Description: … Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum …
Matched Categories: … nalidixic acid …
Matched Products: … ACIDO NALIDIXICO ... ACIDO NALIDIXICO NOVASOREL ... ACIDO NALIDIXICO SUSPENSION …
Dihomo-gamma-linolenic acid
A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.
Investigational
Nutraceutical
Matched International brands: … Tona-lean 1000 CLA …
Matched Synonyms: … (8Z,11Z,14Z)-Icosatrienoic acid ... dihomo-γ-linolenic acid ... 8,11,14-Eicosatrienoic Acid …
Matched Name: … Dihomo-gamma-linolenic acid …
Matched Iupac: … (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid …
Matched Description: … A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. ... It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. …
Matched Categories: … Fatty Acids ... Fatty Acids, Unsaturated …
Matched Synonyms: … (8Z,11Z,14Z)-Icosatrienoic acid ... dihomo-γ-linolenic acid ... 8,11,14-Eicosatrienoic Acid …
Matched Name: … Dihomo-gamma-linolenic acid …
Matched Iupac: … (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid …
Matched Description: … A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. ... It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. …
Matched Categories: … Fatty Acids ... Fatty Acids, Unsaturated …
Miltefosine
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease. It can be administered topically or orally and...
Approved
Investigational
Matched Synonyms: … hexadecyl 2-(trimethylazaniumyl)ethyl phosphate …
Matched Iupac: … hexadecyl 2-(trimethylazaniumyl)ethyl phosphate …
Matched Description: … It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of ... It can be administered topically or orally and is only indicated in patients aged 12 years or older. ... first line treatment for free-living amebae (FLA) infections such as primary amebic meningoencephalitis and …
Matched Categories: … Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …
Matched Iupac: … hexadecyl 2-(trimethylazaniumyl)ethyl phosphate …
Matched Description: … It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of ... It can be administered topically or orally and is only indicated in patients aged 12 years or older. ... first line treatment for free-living amebae (FLA) infections such as primary amebic meningoencephalitis and …
Matched Categories: … Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …
Ioxaglic acid
Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures. Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray film, improving the visualization of important structures and organs during...
Approved
Investigational
Matched Synonyms: … Ioxaglic acid ... acido ioxaglico …
Matched Name: … Ioxaglic acid …
Matched Iupac: … triiodo-5-(2-{[2,4,6-triiodo-3-(methylcarbamoyl)-5-(N-methylacetamido)phenyl]formamido}acetamido)benzoic acid …
Matched Description: … Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray ... Ioxaglic acid has a low osmolarity and is associated with fewer side effects compared to older contrast ... , arthrography, cholangiography, urography, and computed tomography [L1889]. …
Matched Categories: … Contrast Media ... X-Ray Contrast Media, Iodinated ... Acids, Carbocyclic ... Carboxylic Acids ... ioxaglic acid …
Matched Name: … Ioxaglic acid …
Matched Iupac: … triiodo-5-(2-{[2,4,6-triiodo-3-(methylcarbamoyl)-5-(N-methylacetamido)phenyl]formamido}acetamido)benzoic acid …
Matched Description: … Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray ... Ioxaglic acid has a low osmolarity and is associated with fewer side effects compared to older contrast ... , arthrography, cholangiography, urography, and computed tomography [L1889]. …
Matched Categories: … Contrast Media ... X-Ray Contrast Media, Iodinated ... Acids, Carbocyclic ... Carboxylic Acids ... ioxaglic acid …
Acetrizoic acid
Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid and it is the first monomeric ionic compound used as an X-ray contrast agent. It was first synthesized by Wallingford in 1953 and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th,...
Withdrawn
Matched Synonyms: … Urokonic acid ... Acide acetrizoique …
Matched Name: … Acetrizoic acid …
Matched Iupac: … 3-acetamido-2,4,6-triiodobenzoic acid …
Matched Description: … Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid[L1702] and it ... [A32135] It was first synthesized by Wallingford in 1953[A32136] and it was filled in the FDA by the ... [L1704] Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status …
Matched Categories: … Contrast Media ... X-Ray Contrast Media, Iodinated ... Acids, Carbocyclic ... Carboxylic Acids ... acetrizoic acid …
Matched Name: … Acetrizoic acid …
Matched Iupac: … 3-acetamido-2,4,6-triiodobenzoic acid …
Matched Description: … Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid[L1702] and it ... [A32135] It was first synthesized by Wallingford in 1953[A32136] and it was filled in the FDA by the ... [L1704] Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status …
Matched Categories: … Contrast Media ... X-Ray Contrast Media, Iodinated ... Acids, Carbocyclic ... Carboxylic Acids ... acetrizoic acid …
Selenium
Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species [FDA Label]
Approved
Investigational
Vet approved
Matched Description: … of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and …
Matched Mixtures name: … Henkel's Vitamin E and Selenium Cap ... Maxine Vitamin and Mineral Supplement ... Rocky Mountain Multiple Vit and Min Mega Tab …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition …
Matched Products: … Selenious Acid …
Matched Mixtures name: … Henkel's Vitamin E and Selenium Cap ... Maxine Vitamin and Mineral Supplement ... Rocky Mountain Multiple Vit and Min Mega Tab …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition …
Matched Products: … Selenious Acid …
Finafloxacin
Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.
Approved
Investigational
Matched Synonyms: … -3-quinolinecarboxylic acid ... 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro …
Matched Iupac: … octahydropyrrolo[3,4-b]morpholin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid …
Matched Description: … the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and ... Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December …
Matched Iupac: … octahydropyrrolo[3,4-b]morpholin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid …
Matched Description: … the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and ... Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December …
Displaying drugs 776 - 800 of 2861 in total