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Displaying drugs 8601 - 8625 of 11603 in total

IL15-NK Cell

Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity. In particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to.
Investigational

NS13001

Experimental
Matched Iupac: … N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

ZY19489

Investigational
Matched Iupac: … N2-(4-cyclopropyl-5-fluoro-6-methylpyridin-2-yl)-N4-(1,5-dimethyl-1H-pyrazol-3-yl)-5-[(3R)-3,4-dimethylpiperazin ... -1-yl]pyrimidine-2,4-diamine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

ISA101b

ISA101b (peltopepimut-S) is a therapeutic vaccine against the HPV-specific E6/E7 oncoproteins.
Investigational

(1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE

Experimental
Matched Name: … (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE …
Matched Iupac: … (2S)-2-amino-1-[(2S,5R)-2-(aminomethyl)-5-ethynylpyrrolidin-1-yl]-2-cyclopentylethan-1-one …

17-METHYL-17-ALPHA-DIHYDROEQUILENIN

Experimental

S-P-Nitrobenzyloxycarbonylglutathione

Experimental
Matched Iupac: … (2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-({hydroxy[(4-nitrophenyl)methoxy]methyl}sulfanyl …

Adenosine-5'-diphosphate-2',3'-vanadate

Experimental
Matched Name: … Adenosine-5'-diphosphate-2',3'-vanadate …
Matched Iupac: … -4-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid ... [({[(3aR,4S,6R,6aS)-6-(6-amino-9H-purin-9-yl)-2,2-dioxo-tetrahydrofuro[3,4-d]1,3-dioxa-2-vanadacyclopentan …

Fulacimstat

Fulacimstat is under investigation in clinical trial NCT02452515 (A Single-blind Pilot Study to Investigate Safety and Tolerability of the Chymase Inhibitor BAY1142524 in Clinically Stable Patients With Left-ventricular Dysfunction).
Investigational
Matched Iupac: … 1-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)-4-(trifluoromethyl)-2,3-dihydro- ... 1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Niraxostat

Experimental
Matched Iupac: … 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pipamperone

Pipamperone is a typical antipsychotic of the butyrophenone family used in the treatment of schizophrenia. It was developed by Janssen Pharmaceutica in 1961 and started its first round of clinical trials in 1963 [L1514, L1518]. In an effort to improve haloperidol's pharmacological effects, Janssen discovered that pipamperone, an agent whose...
Investigational
Matched Iupac: … 1'-[4-(4-fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide …

ATX-914

Axt914 is under investigation in clinical trial NCT00417261 (Safety, Tolerability, Pharmacodynamic and Pharmacokinetic Effects of Single and Multiple-Doses of ATF936 and AXT914 Administered Orally in Healthy Subjects.).
Investigational
Matched Iupac: … 1-[(2-bromoquinoxalin-6-yl)methyl]-6-(prop-2-yn-1-yloxy)-4-[4-(propan-2-yl)phenyl]-1,2-dihydroquinazolin …

MLN8054

MLN8054 has been used in trials studying the treatment of Colon Neoplasm, Breast Neoplasm, Bladder Neoplasm, Pancreatic Neoplasm, and Advanced Malignancies.
Investigational
Matched Iupac: … 4-{[13-chloro-10-(2,6-difluorophenyl)-3,5,9-triazatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),2,4,6,9,12,14 ... -heptaen-4-yl]amino}benzoic acid …
Matched Salts cas: … 869366-15-4 …

PF-04418948

Pf 04418948 is under investigation in clinical trial NCT01002963 (A Study To Investigate The Safety And Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers).
Investigational
Matched Iupac: … 1-(4-fluorobenzoyl)-3-{[(6-methoxynaphthalen-2-yl)oxy]methyl}azetidine-3-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Tomaralimab

Tomaralimab is under investigation in clinical trial NCT01794663 (Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function).
Investigational

Carbazochrome

Carbazochrome is a hemostatic agent that promotes clotting, preventing blood loss from open wounds. It is an oxidation product of adrenaline which enhances the microcirculatory tone . In the future this may prevent excessive blood flow during surgical operations and the treatment of hemorrhoids, but research on effectiveness and severity...
Experimental
Withdrawn
Matched Synonyms: … 3-Hydroxy-1-methyl-5,6-inodlindionsemicarbazon …
Matched Iupac: … {[(5Z)-3-hydroxy-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indol-5-ylidene]amino}urea …

GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE

Experimental
Matched Name: … GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE …
Matched Iupac: … 3,4-d][1,3]dioxol-2-yl]phosphonic acid ... [(2S,3aR,4R,6R,6aR)-4-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-6-(hydroxymethyl)-tetrahydro-2H-furo[ …

(1R,2S)-2-Phenylcyclopropanaminium

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
Experimental
Matched Synonyms: … (1R,2S)-tranylcypromine(1+) …
Matched Iupac: … (1R,2S)-2-phenylcyclopropan-1-aminium …

(1R)-menthyl hexyl phosphonate group

Experimental

BNT162a1 SARS-CoV-2 Vaccine

BNT162a1 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002, L15007] BNT162a1 is a uridine mRNA (uRNA) vaccine formulated in lipid nanoparticles for delivery via intramuscular injection.[L15002, L15007] BNT162a1 is undergoing evaluation in clinical trials in both the USA (NCT04368728)...
Investigational

6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE

Experimental

(1S)-menthyl hexyl phosphonate group

Experimental

BNT162b1 SARS-CoV-2 Vaccine

BNT162b1 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002, L15007] BNT162b1 is a nucleoside modified mRNA (modRNA) vaccine encoding the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein together with a "foldon" trimerization domain derived from T4 fibritin...
Investigational
Matched Description: … [L15007, L15012] Early results from a phase 1/2 study in 45 healthy adult volunteers demonstrated RBD-binding …

Efruxifermin

Efruxifermin is under investigation in clinical trial NCT06215716 (A Study Evaluating Efruxifermin in Subjects With Non-cirrhotic Nonalcoholic Steatohepatitis (Nash)/metabolic Dysfunction-associated Steatohepatitis (MASH) and Fibrosis).
Investigational
Matched Synonyms: … (ggggs)3 fusion protein with fibroblast growth factor 21 (98-arginine,171-glycine,180-glutamic acid) ... Immunoglobulin g1 (human .gamma.1-chain c-region c-terminal fragment) fusion protein with peptide linker …

Acazicolcept

Investigational
Matched Synonyms: … 1-122-INDUCIBLE COSTIMULATORY LIGAND PROTEIN (52-HISTIDINE,57-TYROSINE,100-ARGININE) (HUMAN) FUSION PROTEIN ... WITH SYNTHETIC PEPTIDE LINKER (GGGGSGGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN .GAMMA.1-CHAIN ... HUMAN INDUCIBLE T-CELL CO-STIMULATOR LIGAND (ICOS LIGAND) N-TERMINAL FRAGMENT (1-122) (VARIANT (N52>H …
Displaying drugs 8601 - 8625 of 11603 in total