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Displaying drugs 10101 - 10125 of 12439 in total

Pirarubicin

Investigational

Sabarubicin

Sabarubicin has been used in trials studying the treatment of Prostate Cancer, Testicular Germ Cell Tumor, and Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Description: … Sabarubicin has been used in trials studying the treatment of Prostate Cancer, Testicular Germ Cell Tumor …

Atopaxar

Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
Investigational
Matched Description: … Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome …

Cotadutide

Cotadutide is under investigation in clinical trial NCT03444584 (Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Subject With Type 2 Diabetes).
Investigational
Matched Iupac: … carbamoyl}-3-carboxypropyl]carbamoyl}-2-hydroxyethyl]carbamoyl}pentyl]carbamoyl}-2-hexadecanamidobutanoic acid …
Matched Description: … Cotadutide is under investigation in clinical trial NCT03444584 (Study of MEDI0382 in Combination With …

Tyrosyladenylate

Experimental

Trabodenoson

Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG).
Investigational
Matched Description: … Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary …

Aviptadil

Experimental
Matched Iupac: … carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acid …

Vasoactive intestinal peptide

Investigational
Matched Iupac: … carboxypropanamido]propanamido]-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxybutanamido]propanoic acid …

Taspoglutide

Taspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of type 2 diabetes being codeveloped by Ipsen and Roche. In September 2010 Roche halted Phase III clinical trials due to incidences of serious hypersensitivity reactions and gastrointestinal side effects. As of May 2013 no...
Investigational
Matched Iupac: … }methyl)carbamoyl]-4-{2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-2-methylpropanamido}butanoic acid …
Matched Description: … As of May 2013 no new trials had been registered. ... pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of ... In September 2010 Roche halted Phase III clinical trials due to incidences of serious hypersensitivity …

Doxofylline

Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies. In contrast with other xanthine derivatives, doxofylline does...
Experimental
Matched Description: … the activities of the phosphodiesterase (PDE) enzyme. ... Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. ... As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but …

Echinacoside

Echinacoside is a phenylethanoid glycoside isolated from Echinacea angustifolia in 1950, and currently being investigated for the treatment of Parkinson's, Alzheimer's, atherosclerosis, osteoporosis, acute colitis, wound treatment, and hepatitis. Echinacoside has demonstrated inhibition of apoptosis in neural cell lines, demonstrating potential for use in the treatment of neurological conditions.
Experimental
Matched Description: … for use in the treatment of neurological conditions. ... isolated from _Echinacea angustifolia_ in 1950, and currently being investigated for the treatment of ... [A184577] Echinacoside has demonstrated inhibition of apoptosis in neural cell lines, demonstrating potential …

Avexitide

Avexitide is under investigation in clinical trial NCT02996812 (Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia).
Investigational
Matched Iupac: … methylpentanamido]-3-hydroxypropanamido]hexanamido]-4-carbamoylbutanamido]-4-(methylsulfanyl)butanamido]butanoic acid …
Matched Description: … of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia). ... Avexitide is under investigation in clinical trial NCT02996812 (Evaluation of Single Ascending Doses …

Brimapitide

Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers).
Investigational
Matched Iupac: … carbamimidamido-1-oxopentan-2-yl]carbamoyl}-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}propanoic acid …
Matched Description: … iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers). ... Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single …

2-Methoxyestradiol

2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
Investigational
Matched Description: … 2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need …

Isoflavone

Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important legumes such as soy, peanut, green peas, chick peas and alfalfa . Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content is 1-2 mg/gram . The main soy isoflavones are mostly...
Experimental
Matched Description: … of soy products associated with a reduced incidences of coronary heart disease, atherosclerosis, type ... Isoflavone is a soy phytoestrogen and a biologically active component of several agriculturally important ... Soybean is an exceptionally rich source of dietary isoflavones, where the average isoflavone content …

Etizolam

Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983...
Experimental

19-norandrostenedione

19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency. In the...
Experimental
Illicit

GMX1777

GMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic activity. In vivo, apoptosis inducer GMX1777 is rapidly converted into GMX1778 through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, GMX1778 appears to antagonize nuclear factor-kappa...
Investigational
Matched Description: … GMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic ... In vivo, apoptosis inducer GMX1777 is rapidly converted into GMX1778 through hydrolytic cleavage of a ... nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis. …

D-JNKI-1

A synthetic, cell permeable peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of both the morphological integrity and physiological function of the organ of Corti during times of oxidative stress.
Investigational
Matched Iupac: … carbamimidamido-1-oxopentan-2-yl]carbamoyl}-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl]carbamoyl}propanoic acid …
Matched Description: … both the morphological integrity and physiological function of the organ of Corti during times of oxidative ... peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of …

Tagatose

Tagatose is a functional sweetener. It is a naturally occurring monosaccharide, specifically a hexose. It is commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of the calories. It is approved as a food additive as a low calorie sweetener. Additionally,...
Investigational
Matched Description: … commonly found in dairy with a similar texture and sweetened capacity to sucrose but with only a third of ... Additionally, it is under investigation by Spherix for the treatment of obesity and type II diabetes. …

Triazavirin

Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain.[A191709,A191625,A191916] It appears that Triazavirin has shown promise in reducing influenza disease severity and associated complications. Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating...
Experimental

Brasofensine

Brasofensine is an orally administered dopamine reuptake inhibitor being developed for the treatment of Parkinson's Disease. Phase I/II trials for brasofensine have been completed in the U.K. In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230.
Investigational
Matched Description: … Brasofensine is an orally administered dopamine reuptake inhibitor being developed for the treatment of ... In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230 …

Bicifadine

Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain.
Investigational
Matched Description: … It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with ... to have potent analgesic activity in vivo and was chosen for further development for the treatment of …

ZYC300

ZYC300 is a plasmid DNA of CYP1B1 encapsulated in biodegradable poly-DL-lactide-coglycolide microparticles. It is designed as a vaccine, intended to increase immune system sensitivity to CYP1B1, an enzyme highly prevalent in tumor cells.
Investigational
Matched Description: … ZYC300 is a plasmid DNA of CYP1B1 encapsulated in biodegradable poly-DL-lactide-coglycolide microparticles …

XL765

XL765 is an orally available small molecule that has been shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). It is being developed by Exelixis, Inc.
Investigational
Matched Description: … phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). ... available small molecule that has been shown in preclinical studies to selectively inhibit the activity of …
Displaying drugs 10101 - 10125 of 12439 in total