Displaying drugs 10426 - 10450 of 12439 in total
HTPEP-001
HTPEP-001 is a novel peptide that works to inhibit the activation of transforming growth factor beta (TGF-β). It is being investigated for the treatment of fibrosis.
Investigational
Matched Description: … It is being investigated for the treatment of fibrosis.[A263527] ... HTPEP-001 is a novel peptide that works to inhibit the activation of transforming growth factor beta …
GEM-231
GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types...
Investigational
Matched Description: … leukemia in older patients and is being studied in the treatment of other types of cancer. ... subunit of cAMP dependent protein kinase. ... GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory …
RG2417
RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism. Uridine is synthesized by the mitochondria, the power plant of the human cell responsible for energy...
Investigational
Matched Description: … metabolism of the brain. ... RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of ... This new insight suggests that the symptoms of bipolar disorder may be linked to dysregulation of energy …
MM-093
MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein normally produced at very high levels by the fetus and present in low levels in the blood of adults and children. Research on AFP suggests that it may play a role in modulating the immune system of...
Investigational
Matched Description: … The presence of hAFP in the pregnant mother’s blood has long been associated with remission of many autoimmune ... MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein ... normally produced at very high levels by the fetus and present in low levels in the blood of adults and …
Oportuzumab monatox
VB4-845 is studied in the treatment of certain types of head and neck cancer. VB4-845 is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. VB4-845 is a fusion protein containing humanized scFv specific for the epithelial cell adhesion molecule, Ep-CAM, a tumor...
Investigational
Matched Description: … VB4-845 is studied in the treatment of certain types of head and neck cancer. ... epithelial origin and a truncated portion of Pseudomonas exotoxin A. ... cell adhesion molecule, Ep-CAM, a tumor cell-associated target highly expressed on carcinoma cells of …
EPC2407
EPC2407 is a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of patients with advanced solid tumors and lymphomas. It is intended for the treatment of advanced cancer patients with solid tumors that are well vascularized. These tumors
include the frequently occurring cancers of the lung,...
Investigational
Matched Description: … EPC2407 is a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of ... These tumors
include the frequently occurring cancers of the lung, gastrointestinal tract, ovaries, ... It is intended for the treatment of advanced cancer patients with solid tumors that are well vascularized …
VSF-173
VSF-173 is an oral small molecule. It is an oral compound that has demonstrated effects on animal sleep/wake patterns and gene expression patterns suggestive of a stimulant effect. It is developed for the treatment of excessive sleepiness. Study shows that VSF-173 possesses a novel mechanism to address disorders of excessive...
Investigational
Matched Description: … It is developed for the treatment of excessive sleepiness. ... that has demonstrated effects on animal sleep/wake patterns and gene expression patterns suggestive of ... Study shows that VSF-173 possesses a novel mechanism to address disorders of excessive sleepiness. …
Human Menstrual Blood-derived Stem Cells
Stem cells are self-renewing and proliferate without differentiation, with the two major groups being embryonic stem cells (ESCs) and adult stem cells (ASC). Differentiation occurs under different conditions into different cell types. ESCs are from the inner cell mass of blastocysts while ASCs are deposited into adult tissues with restricted...
Investigational
Matched Description: … differentiation potency but also a lack of tumorigenicity. ... ethical issues that may come from obtaining stem cells of the embryonic kind. ... These cells possess a high rate of proliferation and multi-lineage differentiation potency. …
Reloxiliase
Reloxiliase is a first-in-class, oral crystalline formulation of the oxalate-specific, microbial enzyme oxalate decarboxylase. It is being investigated for the treatment of hyperoxaluria.
Investigational
Matched Description: … It is being investigated for the treatment of hyperoxaluria.[A258823] ... Reloxiliase is a first-in-class, oral crystalline formulation of the oxalate-specific, microbial enzyme …
Resiniferatoxin
Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).
Investigational
Matched Description: … primary afferent sensory neurons involved in nociception (the transmission of physiological pain). ... naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of …
IPI-549
IPI-549 is under investigation in clinical trial NCT03795610 (Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma).
Investigational
Matched Description: … IPI-549 is under investigation in clinical trial NCT03795610 (Window of Opportunity Study of IPI-549 …
CCX915
CCX915 is developed by ChemoCentryx which targets the chemokine receptor CCR2 and is in phase 1 of clinical trial for the treatment of Multiple Sclerosis and Neurologic Disorders. The CCR2 receptor is thought to be of central importance to inflammatory diseases, such as multiple sclerosis (MS), Type II diabetes and...
Investigational
Matched Description: … trial for the treatment of Multiple Sclerosis and Neurologic Disorders. ... CCX915 is developed by ChemoCentryx which targets the chemokine receptor CCR2 and is in phase 1 of clinical ... The CCR2 receptor is thought to be of central importance to inflammatory diseases, such as multiple sclerosis …
ZEN-012
ZEN-012 is a novel small molecule and the first anti-cancer drug in development involving two mechanisms of action: tubulin and topoisomerase II inhibition. ZEN-012 also expresses additional modes of action such as pro-apoptotic and anti-angiogenic properties. It is developed for the treatment of solid tumors.
Investigational
Matched Description: … It is developed for the treatment of solid tumors. ... 012 is a novel small molecule and the first anti-cancer drug in development involving two mechanisms of ... ZEN-012 also expresses additional modes of action such as pro-apoptotic and anti-angiogenic properties …
COVID-19 Nucleocapsid-GM-CSF Protein Lactated Ringer's Injection
As of July 2020, Medicine Invention Design, Inc. is sponsoring a small, controlled clinical trial for the COVID-19 AP TP Vaccine for ‘proof of concept.’ The vaccine utilizes granulocyte macrophage-colony stimulating factor (GM-CSF), a cytokine known to enhance vaccine efficacy through prolongation of humoral and cell immunity.
Investigational
Matched Description: … the COVID-19 AP TP Vaccine for ‘proof of concept.’ ... As of July 2020, Medicine Invention Design, Inc. is sponsoring a small, controlled clinical trial for ... macrophage-colony stimulating factor (GM-CSF), a cytokine known to enhance vaccine efficacy through prolongation of …
OTL-201
OTL-201 is an investigational hematopoietic stem cell (HSC) gene therapy being developed by Orchard Therapeutics for the treatment of mucopolysaccharidosis type IIIA (MPS-IIIA). It consists of a lentiviral vector to insert a functional copy of the human N-Sulfoglucosamine Sulfohydrolase (SGSH) gene into autologous CD34+ hematopoietic stem cells.
Investigational
Matched Description: … It consists of a lentiviral vector to insert a functional copy of the human N-Sulfoglucosamine Sulfohydrolase ... hematopoietic stem cell (HSC) gene therapy being developed by Orchard Therapeutics for the treatment of …
Cytisine
Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as...
Experimental
Matched Description: … similar efficacy to varenicline, but at a fraction of the cost. ... Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. ... Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum …
Cusatuzumab
CD70 is a ligand expressed on the surface of activated lymphocytes and mature dendritic cells that, in its binding to CD27 receptors, plays an important role in cell proliferation and survival. An overexpression of CD70 can result in the proliferation of malignant cells and has been documented in a variety...
Investigational
Matched Description: … An overexpression of CD70 can result in the proliferation of malignant cells and has been documented ... in a variety of solid and hematological malignancies. ... CD70 is a ligand expressed on the surface of activated lymphocytes and mature dendritic cells that, in …
Equilenin
Equilenin is an estrogenic steroid produced by horses. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the urine of pregnant mares.
Experimental
Matched Description: … High concentration of equilenin is found in the urine of pregnant mares. ... It has a total of five double bonds in the A- and B-ring. …
NX-1207
NX-1207 is an investigational new drug for BPH, whose chemical entity and mechanism of action remain undisclosed. Nymox Pharmaceutical Corporation recently completed studies of NX-1207 for treatment of benign prostatic hyperplasia (BPH).
Investigational
Matched Description: … Nymox Pharmaceutical Corporation recently completed studies of NX-1207 for treatment of benign prostatic ... NX-1207 is an investigational new drug for BPH, whose chemical entity and mechanism of action remain …
Vitex agnus-castus fruit extract
Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. The fruits contain mixture of iridoids, flavonoids and compounds in leaves and flowers that structurally resemble sex hormones. Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of premenstrual stress syndrome (PMS) and cyclical breast...
Experimental
Matched Description: … Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of ... The main mechanism of action of vitex agnus-castus fruit extract has not been fully elucidated, however ... Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. …
R411
R411 is a non-steroid oral medicine for the treatment of asthma. It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory inflammation. It is a dual-acting competitive integrin antagonist (as compared to previously developed single integrin antagonists or SIAs) that prevents binding of V-CAM1 to...
Investigational
Matched Description: … R411 is a non-steroid oral medicine for the treatment of asthma. ... It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory ... antagonist (as compared to previously developed single integrin antagonists or SIAs) that prevents binding of …
RTA 744
RTA 744 is a novel anthracycline derivative that crosses the blood-brain barrier and shows significant potential for the treatment of primary and metastatic brain cancers. Anthracyclines are one of the most broadly used and effective classes of cancer therapies; however, they are not used to treat brain cancers because current...
Investigational
Matched Description: … Anthracyclines are one of the most broadly used and effective classes of cancer therapies; however, they ... anthracycline derivative that crosses the blood-brain barrier and shows significant potential for the treatment of …
Glutaral
One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
Experimental
Matched Description: … One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive …
HX-1171
Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety, Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects).
Investigational
Matched Description: … , Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects). ... Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety …
PF-05089771
PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).
Investigational
Matched Description: … PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee). ... PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of …
Displaying drugs 10426 - 10450 of 12439 in total