Displaying drugs 1051 - 1075 of 14604 in total
Bifonazole
Bifonazole is an azole antifungal drug.
Approved
Investigational
Matched Categories: … Imidazole and Triazole Derivatives …
Midodrine
An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Approved
Matched Categories: … Adrenergic and Dopaminergic Agents …
Olsalazine
Olsalazine is an aminosalicylate and a prodrug of mesalamine (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of sulfapyridine. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inflammatory agent that works...
Approved
Matched Description: … Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). ... , subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene ... [A257078] Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Categories: … Alimentary Tract and Metabolism …
Betahistine
Ménière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing loss. It has a significant impact on both the physical and social functioning of affected individuals.[A220318,L16408]
Betahistine is a histamine-like antivertigo drug used for treating symptoms associated with Ménière's disease. It is thought to...
Approved
Investigational
Matched Description: … It has a significant impact on both the physical and social functioning of affected individuals. ... Ménière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing …
Tavaborole
Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to Trichophyton rubrum or Trichophyton mentagrophytes infection. Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis...
Approved
Investigational
Matched Description: … boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and ... inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and …
Thiopental
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not...
Approved
Vet approved
Matched Description: … It is also used for hypnosis and for the control of convulsive states. ... Small doses have been shown to be anti-analgesic and lower the pain threshold. ... It does not produce any excitation but has poor analgesic and muscle relaxant properties. …
Matched Categories: … Hypnotics and Sedatives …
Matched Categories: … Hypnotics and Sedatives …
Recombinant stabilized RSV B prefusion F antigen
Recombinant stabilized RSV B prefusion F antigen is one component of a bivalent respiratory syncytial virus (RSV) vaccine called Abrysvo. The vaccine comprises two antigens - the other being recombinant stabilized RSV A prefusion F antigen - which have been expressed in Chinese hamster ovary cell lines and then purified...
Approved
Matched Description: … then purified and lyophilized. ... stabilized RSV A prefusion F antigen] - which have been expressed in Chinese hamster ovary cell lines and ... virus vaccine, adjuvanted] (Arexvy), Abrysvo is reconstituted with sterile water prior to injection and …
Disopyramide
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Approved
Matched Description: … It also possesses some anticholinergic and local anesthetic properties. ... anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and …
Choline magnesium trisalicylate
Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28% [A19653, A19654].
Approved
Ribostamycin
Ribostamycin is an aminoglycoside antibiotic isolated from Streptomyces ribosidificus listed as one of the World Health Organization's critically important antimicrobials.
Approved
Experimental
Fursultiamine
Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.
Approved
Iodohippurate sodium I-131
Approved
Meglumine
Approved
Equine Botulinum Neurotoxin E Immune FAB2
Equine Botulinum Neurotoxin E Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype E. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes E in...
Approved
Experimental
Investigational
Matched Description: … symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes E in adults and …
Equine Botulinum Neurotoxin C Immune FAB2
Equine Botulinum Neurotoxin C Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype C. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes C in...
Approved
Experimental
Investigational
Matched Description: … symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes C in adults and …
Avacincaptad pegol
Avacincaptad pegol is an RNA aptamer covalently bound to a branched polyethylene glycol (PEG) molecule. It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA). AMD is the leading cause of vision loss in developed countries for people over 50 years old, with...
Approved
Investigational
Matched Description: … AMD eventually progresses to bilateral and irreversible loss of vision, whether or not the patients have ... This approval is based on the positive results obtained from 2 phase 3 clinical trials GATHER1 and GATHER2 …
Brilliant green cation
Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool. Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection.
Approved
Vet approved
Matched Description: … green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and ... Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and …
Viper antivenom
Viper antivenom consists of antibodies derived from horses immunized and subsequently developed antibodies against snake venoms. ANAVIP, an equine-derived antivenom made with venom from Bothrops asper and Crotalus durissus, was first approved by the FDA on October 1, 2015, for the management of North American rattlesnake envenomation.
Approved
Matched Description: … Viper antivenom consists of antibodies derived from horses immunized and subsequently developed antibodies ... ANAVIP, an equine-derived antivenom made with venom from _Bothrops asper_ and _Crotalus durissus_, was …
Trimipramine
Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Approved
Matched Description: … Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Kappadione
Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Description: … derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and ... marketed by Lilly Marketing for this drug has been discontinued and is not available in North America …
Efmoroctocog alfa
Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as DB13999 . It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It...
Approved
Investigational
Matched Description: … is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. ... other hemorrhages that cause chronic pain and disability to patients [A31551, A31552]. ... Patients with this disorder are more susceptible to recurrent bleeding episodes and excessive bleeding …
Nonoxynol-9
Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams,...
Approved
Withdrawn
Matched Description: … It is the most commonly used spermicidal contraceptive in the UK and the USA. ... N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and ... When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without …
Phentolamine
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including...
Approved
Matched Description: … to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and ... [L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and ... norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and …
Displaying drugs 1051 - 1075 of 14604 in total