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Displaying drugs 1126 - 1150 of 1382 in total

Romosozumab

Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant to other osteoperosis therapies . Romosozumab prevents bone resorption and induces the formation of bone though it is associated...
Approved
Investigational
Matched Description: … In a comparison study of post menopausal women with osteoporosis and a past fracture, romosozumab for ... women at high risk of fracture and patients who have failed in other treatments or are intolerant to ... increased risk of cardiac death, heart attack, and stroke in one study[L5921,L5924]. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs Affecting Bone Structure and Mineralization ... Drugs for Treatment of Bone Diseases …
Matched Products: … EVENITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 105 MG/1.17 ML ... EVENITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 105MG/1.17ML …

Rasburicase

Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus.
Approved
Investigational
Matched Description: … The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_. …
Matched Categories: … Enzymes and Coenzymes ... Detoxifying Agents for Antineoplastic Treatment …
Matched Products: … FASTURTEC POWDER FOR SOLUTION FOR INFUSION 1.5 mg/vial …

Gadoxetic acid

Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. Gadoxetate is a...
Approved
Matched Description: … hepatobiliary phase and thus has different pharmacokinetic and pharmacodynamic properties compared to ... under the brand name EOVIST and FDA approved in 2008. ... Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and …
Matched Products: … Primovist 0.25 mmol/ml Solution for injection ... PRIMOVIST 0.25 MMOL/ML, SOLUTION FOR INJECTION …

4,6-Dideoxy-4-{[(1S,5R,6S)-3-formyl-5,6-dihydroxy-4-oxo-2-cyclohexen-1-yl]amino}-α-D-xylo-hex-5-enopyranose

Experimental
Matched Synonyms: … 4,6-Dideoxy-4-{[(1s,5r,6s)-3-formyl-5,6-dihydroxy-4-oxocyclohex-2-en-1-yl]amino}-alpha-d-xylo-hex-5-enopyranose …
Matched Name: … 4,6-Dideoxy-4-{[(1S,5R,6S)-3-formyl-5,6-dihydroxy-4-oxo-2-cyclohexen-1-yl]amino}-α-D-xylo-hex-5-enopyranose …

Antithrombin III human

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Approved
Matched Description: … A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Matched Products: … Anbinex Powder For Injection 500 I.U. ... Anbinex Powder For Injection 1000 I.U. …

Cefazolin

A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Approved
Matched Description: … It attains high serum levels and is excreted quickly via the urine. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … CEFAZOLIN ALVOGEN POWDER FOR SOLUTION FOR INJECTION OR INFUSION 1G/VIAL ... Cefazolin for Injection ... Cefazolin for Injection USP …

3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE

Experimental
Matched Name: … 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE …
Matched Iupac: … (2S,3R)-3-formyl-N,2-dihydroxy-5-methylhexanamide …

Potassium chloride

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of...
Approved
Withdrawn
Matched Description: … forms and those products formulated for preparation of solution prior to ingestion. ... in fertilizers and explosives. ... crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and …
Matched Mixtures name: … Peg-3350, Sodium Sulfate, Sodium Chloride, Potassium Chloride, Sodium Ascorbate and Ascorbic Acid ... Calcium Magnesium With Potassium Tab ... Medi SM 24K Gold Hydrogel Peptide Mask Pack …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Potassium Chloride for Oral Solution ... Potassium Chloride for Hemodialysis 7.55 ... Potassium Chloride for Injection Concentrate …

Dantrolene

Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.
Approved
Investigational
Matched Categories: … Dantrolene and Derivatives …
Matched Products: … Dantrolene Sodium for Injection, USP …

Hepatitis B Vaccine (Recombinant)

Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis...
Approved
Withdrawn
Matched Description: … There is no specific treatment for hepatitis. ... The hepatitis B virus induces a severe form of viral hepatitis. ... Other causative agents are hepatitis A virus, and the non-A, non-B hepatitis viruses. …
Matched Mixtures name: … Hexaxim Suspension for Injection …
Matched Categories: … Antiinfectives for Systemic Use ... Amino Acids, Peptides, and Proteins ... Bacterial and viral vaccines, combined ... haemophilus influenzae B and hepatitis B …
Matched Products: … Engerix-B 20 Adult Dose Suspension for Injection ... Engerix-B 10 Junior Dose Suspension for Injection ... ENGERIX-B SUSPENSION FOR INJECTION IN PREFILLED SYRINGE 20MCG/ML …

Ioflupane I-123

Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.
Approved
Matched Description: … Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes …
Matched Products: … DATSCAN SOLUTION FOR INJECTION 74 MBQ/ML …

Technetium Tc-99m sestamibi

Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by...
Approved
Investigational
Matched Description: … for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and ... , and/or breast tissue. ... infarction (non-reversible defects); and 2) evaluating myocardial function and developing information …
Matched Categories: … Indicators and Reagents …
Matched Products: … Kit for the Preparation of Technetium Tc99m Sestamibi …

Nefopam

Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.
Approved
Investigational
Matched Description: … Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. ... Nefopam has been investigated for the prevention of Kidney Transplantation. …
Matched Products: … ACUPAN SOLUTION FOR INJECTION 20MG/2ML …

Arsenic trioxide

Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous...
Approved
Investigational
Matched Description: … The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Arsenic Trioxide for Injection ... Teva-arsenic Trioxide for Injection ... Arsenic Trioxide Solution for Injection …

Clostridium botulinum

Experimental
Matched Products: … DYSPORT FOR INJECTION 300u/vial ... DYSPORT FOR INJECTION 500 u/vial ... NEURONOX LYOPHILIZED POWDER FOR INJECTION 100 UNITS/VIAL …

Filgrastim

Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in E. Coli. Human...
Approved
Matched Description: … [L40719] It has a number of therapeutic uses, including the management and prevention of infections and ... cell collection and therapy. ... acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Nivestim 120 mcg/0.2 ml solution for injection/infusion ... Nivestim 300mcg/0.5ml solution for Injection/Infusion ... Nivestim 120mcg/0.2mL Solution for Injection/Infusion …

Temsirolimus

Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Approved
Matched Iupac: … 30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Sirolimus and Prodrugs …
Matched Products: … Torisel Concentrate for Injection 25mg/mL …

Dactinomycin

A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Description: … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …
Matched Products: … DACTINOMYCIN FOR INJECTION 0.5 mg/vial …

Rofecoxib

Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 )...
Approved
Investigational
Withdrawn
Matched Description: … Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and ... doses of 125, 25, and 50 mg is approximately 93%. ... The proteins that rofecoxib target include elastin and prostaglandin G/H synthase 2. …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … REOX 25 MG FORT TABLET, 14 ADET ... REOX 25 MG FORT TABLET, 28 ADET …

Melphalan

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Description: … [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. ... [L40928] It is also used for high-conditioning before hematopoietic stem cell transplant. ... [L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group …
Matched Mixtures name: … Melphalan for Injection ... Melphalan for Injection …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Melphalan for Injection ... ALKERAN FOR INJECTION 50 mg/vial …

Carbocisteine

Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD) and other respiratory conditions characterized by increased mucus production. Individuals with COPD have a greater risk of pulmonary infection due to the growth and accumulation of viruses and bacteria in thick bronchial mucus. Carbocisteine is a mucolytic drug...
Approved
Investigational
Matched Description: … [L32383] Several licenses for this drug were withdrawn following serious and fatal paradoxical effects ... Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD)[A231169] and other ... viruses and bacteria in thick bronchial mucus. …
Matched Mixtures name: … AXIM TOSTHERAPY FORTE® …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Cough and Cold Preparations …
Matched Products: … MUKO-S FORT 375 MG TABLET , 20 ADET ... MUKOTIK FORT 375 MG TABLET, 20 ADET ... MUKOTIK FORT 375 MG TABLET, 50 ADET …

Fremanezumab

Fremanezumab is a humanized monoclonal antibody targeted against human calcitonin gene-related peptide (CGRP) for the prevention of migraine headaches. It was developed by Teva Pharmaceuticals USA and approved by the FDA in September 2018. Along with other recently approved anti-CGRP therapies such as galcanezumab, erenumab, and the oral CGRP antagonist...
Approved
Investigational
Matched Description: … [L11749] It was developed by Teva Pharmaceuticals USA and approved by the FDA in September 2018. ... [L11779] Along with other recently approved anti-CGRP therapies such as [galcanezumab], [erenumab], and ... oral CGRP antagonist [ubrogepant], fremanezumab represents an important step forward in the treatment and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … AJOVY SOLUTION FOR INJECTION IN PRE-FILLED PEN 225 MG/1.5ML ... AJOVY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 225 MG/1.5ML …

Cloprostenol

Vet approved
Matched Categories: … Hormonal Contraceptives for Systemic Use …
Matched Products: … GESTAVET PROST (d-cloprostenol 75 mcg/ml solution for injection) …

Vigabatrin

Vigabatrin is an analog of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although administered as a racemic mixture, only the...
Approved
Matched Description: … [A202124] Its use is now generally reserved for patients who have failed alternative therapies, and its ... inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and ... [A202037] It was first introduced as an antiepileptic agent in the United Kingdom in 1989 and was …
Matched Products: … Vigabatrin for Oral Solution ... Vigabatrin for oral solution USP, 500 mg …

Olodaterol

Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and...
Approved
Matched Description: … novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and ... LABAs including improved convenience and compliance and improved airflow over a 24-hour period. ... (COPD) and the progressive airflow obstruction that is characteristic of it. …
Matched Categories: … olodaterol and tiotropium bromide ... Drugs for Obstructive Airway Diseases …
Matched Products: … Striverdi Respimat Solution for Inhalation 2.5 microgram/ actuation ... SPIOLTO® RESPIMAT® RE-USABLE SOLUTION FOR INHALATION 2.5 MICROGRAM / 2.5 MICROGRAM …
Displaying drugs 1126 - 1150 of 1382 in total