Ioflupane I-123

DB08824ApprovedInvestigationalSmall moleculeRadioactive Diagnostic Agent

Ioflupane I-123 is a radiopharmaceutical used in single photon emission computed tomography (SPECT) brain imaging to help diagnose patients with suspected Parkinsonian syndromes. A product used in medical brain imaging to help healthcare providers diagnose Parkinson's Disease.

Chemical structure of Ioflupane I-123
Mechanism
Curator reviewed
Primary indication
Ioflupane I-123 is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor.Curator reviewed · 1 structured indication
Formula / weight
C18H23FINO2 · 427.291 g/mol (avg)
First approval
United States, 2011 · European Union, 2016
Also known as
123I-FP-CIT · 123I-Ioflupane · Iodine ioflupane (123I) · Ioflupane (123I) · Ioflupane I 123
Brand names
  • Datscan
  • Striascan

Resolves to

Compound
UNII3MM99T8R5QCAS155798-07-5ChEMBLCHEMBL3989517ChEBI68855PubChem3086674KEGGD10014
Clinical / RWD
RxNorm1426874ATCV09AB03
Structure
InChIKeyHXWLAJVUJSVENX-HFIFKADTSA-NSMILES[H][C@]12CC[C@]([H])([C@H]([C@H](C1)C1=CC=C([123I])C=C1)C(=O)OC)N2CCCF
Targets
Q01959SLC6A3
Transporters
Q01959SLC6A3

What you can answer from here — as of March 03, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
Listed above
773Drug interactionsStructured to mechanism, not free text
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15Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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1ContraindicationEach with its own population and attribute set
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19Marketed productsAcross 6 countries and 7 labellers
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1ATC codeIncluding every combination product, plus 12 drug categories
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5+ReferencesStructured and connected to the statements they support
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